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Mitochondrial Diseases (Mitochondrial Disease)

Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
Also Known As:
Mitochondrial Disease; Mitochondrial Disorders; Mitochondrial Electron Transport Chain Deficiencies; Mitochondrial Respiratory Chain Deficiencies; Defect, Mitochondrial; Deficiency, Oxidative Phosphorylation; Disease, Mitochondrial; Disorder, Mitochondrial; Dysfunction, Mitochondria; Dysfunction, Mitochondrial; Mitochondria Dysfunctions; Mitochondrial Defects; Mitochondrial Disorder; Mitochondrial Dysfunctions; Oxidative Phosphorylation Deficiency; Phosphorylation Deficiency, Oxidative; Electron Transport Chain Deficiencies, Mitochondrial; Mitochondria Dysfunction; Mitochondrial Defect; Mitochondrial Dysfunction; Oxidative Phosphorylation Deficiencies; Respiratory Chain Deficiencies, Mitochondrial
Networked: 21919 relevant articles (903 outcomes, 2080 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Inflammation (Inflammations)
2. Neuroinflammatory Diseases
3. Insulin Resistance
4. Neoplasms (Cancer)
5. Parkinson Disease (Parkinson's Disease)

Experts

1. Taylor, Robert W: 105 articles (04/2022 - 07/2002)
2. Chattipakorn, Nipon: 83 articles (10/2022 - 05/2011)
3. Chattipakorn, Siriporn C: 67 articles (10/2022 - 08/2012)
4. Zeviani, Massimo: 55 articles (10/2022 - 09/2003)
5. Chinnery, Patrick F: 52 articles (01/2022 - 07/2002)
6. McFarland, Robert: 50 articles (04/2022 - 08/2010)
7. Finsterer, Josef: 49 articles (05/2022 - 04/2005)
8. Jaeschke, Hartmut: 49 articles (01/2022 - 02/2002)
9. Turnbull, Doug M: 46 articles (12/2022 - 03/2008)
10. Liu, Jiankang: 45 articles (01/2021 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mitochondrial Diseases:
1. Proteins (Proteins, Gene)FDA Link
2. Adenosine Triphosphate (ATP)IBA
3. AntioxidantsIBA
4. Glucose (Dextrose)FDA LinkGeneric
5. Reactive Oxygen Species (Oxygen Radicals)IBA
6. Mitochondrial DNA (mtDNA)IBA
7. EnzymesIBA
02/28/2014 - "These findings suggested that TCA cycle enzymes inhibition can be an important link for the mitochondrial dysfunction seen in BD, and TMX exert protective effects against the d-AMPH-induced TCA cycle enzymes dysfunction."
12/01/2013 - "These findings suggest that Krebs cycle enzymes' inhibition can be an important link for the mitochondrial dysfunction seen in BD and SB exerts protective effects against the D-AMPH-induced Krebs cycle enzymes' dysfunction. "
06/12/2018 - "(3) The results from pharmacological evaluation revealed that CBIs and QSYQ, but not RIs, significantly prevented myocardium injury; improved the ejection fraction (EF) and fractional shortening (FS); decreased the release of cardiac enzymes, including CK, CK-MB, and LDH; alleviated mitochondrial dysfunction; and protected the cell nucleus number and mitochondrial mass. "
09/25/2007 - "This variant enzyme displayed significantly improved aminoacylation efficiency for the G34A mutant, suggesting a general strategy to treat certain classes of mitochondrial diseases by modification of the corresponding nuclear gene."
05/09/1997 - "Thus, our nuclear transfer system is effective for determining whether a mitochondrial or nuclear genome of a patient is responsible for a disease and whether deficiency of mitochondrial enzymes, including enzymes exclusively encoded by nuclear genomes, is transmitted in a nuclear recessive or nuclear dominant way, providing the parents of the patients with valuable information for genetic counseling on the risk of mitochondrial diseases in their next babies."
8. MelatoninIBA
9. LipidsIBA
10. coenzyme Q10 (CoQ10)IBA

Therapies and Procedures

1. Therapeutics
2. Transplantation
3. Ketogenic Diet
4. Drug Therapy (Chemotherapy)
5. Radiotherapy