Activins (Activin)

Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.

Also Known As:

Networked: 556 relevant articles (5 outcomes, 84 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mylonas, Ioannis: 18 articles (08/2011 - 01/2005)
2.	Phillips, David J: 11 articles (01/2012 - 07/2003)
3.	Friese, Klaus: 11 articles (07/2011 - 01/2005)
4.	Gold, Elspeth: 10 articles (12/2015 - 01/2009)
5.	Shabani, Naim: 10 articles (07/2011 - 01/2005)
6.	Werner, Sabine: 9 articles (12/2013 - 05/2003)
7.	Kuhn, Christina: 9 articles (07/2011 - 01/2005)
8.	Jeschke, Udo: 9 articles (09/2010 - 01/2005)
9.	Risbridger, Gail: 8 articles (12/2015 - 01/2009)
10.	Brüning, Ansgar: 8 articles (07/2011 - 05/2009)

Related Diseases

1.	Fibrosis (Cirrhosis) 04/01/2014 - "Critically, we demonstrate that the muscle wasting and fibrosis that ensues in response to excessive activin levels is fully reversible. " 09/01/2012 - "These findings provide the basis for the use of activin or its downstream targets for the improvement of impaired wound healing, and of activin antagonists for the prevention and treatment of fibrosis and of malignant tumours that overexpress activin. " 09/01/2011 - "This reduction in fibrosis was associated with attenuated inflammatory cell numbers, reduced interstitial myofibroblast numbers and attenuated activity of the TGF-β1 system, indicated by reductions in the expression of TGF-β1 and its receptors activin-like kinase-5 and type II TGF-β receptor. " 01/01/2010 - "BAMBI (BMP and Activin Membrane Bound Inhibitor) is considered to influence TGFβ and Wnt signaling, and thereby fibrosis. " 06/01/2006 - "Roles of activin in tissue repair, fibrosis, and inflammatory disease."
2.	Wounds and Injuries (Trauma) 12/15/2013 - "Using single- and double-mutant mice, we show that loss of mast cells neither affected the stimulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of skin wounds nor its protumorigenic activity in a model of chemically induced skin carcinogenesis. " 01/01/2011 - "Activin is an important orchestrator of wound repair, but its potential role in skin carcinogenesis has not been addressed. " 02/01/2009 - "These results demonstrate that selective activation of activin in the epidermis enhances reepithelialization without affecting the quality of the healed wound." 11/15/2006 - "This review focuses on the role of activin as a target-derived differentiative factor in neural development that has additional roles in response to cutaneous injuries in the adult." 09/01/2005 - "Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes."
3.	Hyperplasia 09/01/2011 - "TGFβ/activin signaling pathway activation in intimal hyperplasia and atherosclerosis." 11/01/2011 - "Moreover, deletion of Fstl3, an antagonist of activin and myostatin, resulted in enlarged islets and ß-cell hyperplasia. " 09/01/2001 - "Excess activin or insufficient follistatin may contribute to T-I hyperplasia." 05/01/2005 - "Since the inhibin/activin subunits reacted positively with trophoblastic tissue, they might be a useful diagnostic marker for hydatidiform mole with persistence of polymorphic trophoblastic hyperplasia." 07/01/2015 - "We previously demonstrated that Fstl3 (an antagonist of activin activity) null mice have larger islets with β-cell hyperplasia and improved glucose tolerance and insulin sensitivity in the absence of altered β-cell proliferation. "
4.	Acute Lung Injury 09/15/2005 - "Follistatin is effective in treating acute lung injury and BLM-induced fibrosis by blocking the actions of activin and transforming growth factor-beta." 06/01/2013 - "Activin antagonists such as follistatin, an endogenous activin-binding protein, offer considerable promise as therapies in conditions as diverse as sepsis, liver fibrosis, acute lung injury, asthma, wound healing and ischaemia-reperfusion injury. "
5.	Hypertrophic Cicatrix (Hypertrophic Scar) 07/01/2007 - "Ex-vivo AHS fibroblasts produced more activin and less follistatin than normal skin or remission phase hypertrophic scar (HS) fibroblasts, both in basal conditions and upon TGF-betas stimulation. "

Related Drugs and Biologics

1.	Follistatin
2.	Transforming Growth Factor beta (TGF-beta)
3.	Insulin (Novolin)
4.	Glucose (Dextrose)
5.	Inhibins (Inhibin)
6.	Activin Receptors (Activin Receptor)
7.	activin A
8.	Messenger RNA (mRNA)
9.	inhibin A
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Mammaplasty (Breast Reconstruction)
3.	Segmental Mastectomy (Lumpectomy)
4.	Transplantation (Transplant Recipients)
5.	Therapeutics