Polyomavirus Infections

Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).

Also Known As:

Networked: 102 relevant articles (0 outcomes, 6 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Interstitial Nephritis (Tubulointerstitial Nephritis)
2.	Infection
3.	Merkel Cell Carcinoma
4.	Neoplasms (Cancer)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Nickeleit, Volker: 3 articles (11/2015 - 01/2006)
2.	Singh, Harsharan K: 3 articles (11/2015 - 01/2006)
3.	Atwood, Walter J: 3 articles (09/2014 - 02/2006)
4.	Lukacher, Aron E: 3 articles (10/2011 - 05/2010)
5.	Butel, Janet S: 3 articles (08/2009 - 11/2002)
6.	Vilchez, Regis A: 3 articles (08/2009 - 11/2002)
7.	Forstová, Jitka: 3 articles (06/2008 - 02/2003)
8.	Kenan, Daniel J: 2 articles (11/2015 - 12/2013)
9.	Matsushita, Michiko: 2 articles (09/2015 - 03/2013)
10.	Papadimitriou, John C: 2 articles (09/2015 - 12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Polyomavirus Infections:

1.	Immunoglobulin G (IgG)IBA 04/01/2014 - "We used comprehensive serodiagnostic methods (IgM, IgG, and IgG avidity) and PCR to study Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus infections in children observed from infancy to adolescence. " 02/01/2013 - "Common WU polyomavirus infection in a Beijing population indicated by surveillance for serum IgG antibody against capsid protein VP2." 08/15/2006 - "T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient mice." 09/01/1987 - "When mixed with anti-idiotype immunoglobulin G (IgG), E7 was no longer capable of binding or immunoprecipitating polyomavirus virions or neutralizing polyomavirus infection. "
2.	Proteins (Proteins, Gene)IBA 01/01/2011 - "Further studies of these proteins will provide insight into the molecular mechanisms of polyomavirus infection and ER function." 04/01/2015 - "Recent investigation suggests that these essential DDR proteins are required for productive polyomavirus infection. " 10/01/2010 - "Lipids and proteins act in opposing manners to regulate polyomavirus infection."
3.	Immunoglobulin M (IgM)IBA 03/01/1998 - "Adult X-linked immunodeficiency (XID) mice, IGM-/- single knockout and IGM-/- CD8-/- double knockout mice do not clear polyomavirus infection." 06/01/1981 - "No Bk-virus-specific IgM was detected in any of the samples of cord blood from the babies born to these women with evidence of polyomavirus infection. " 04/01/2014 - "We used comprehensive serodiagnostic methods (IgM, IgG, and IgG avidity) and PCR to study Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus infections in children observed from infancy to adolescence. " 03/01/1998 - "The importance of antibodies for elimination of polyomavirus infection and the prevention of virus induced oncogenesis was studied, X-linked immunodeficiency (XID) mice, IgM-/- single knockout and IgMI-/- CD8-/- double knockout mice, all defective in antibody production, and normal control mice were infected with polyomavirus as adults. "
4.	Tumor Viral Antigens (Large T Antigen)IBA 09/01/2015 - "Strong expression of polyomavirus large T antigen (SV40) and VP1 was seen in atypical lesional cells, consistent with cytopathic lytic polyomavirus infection. " 06/01/2006 - "Polyomavirus infection was confirmed by immunohistochemical detection of T antigen in kidney and bladder biopsies. " 02/01/1985 - "Small and middle T antigens contribute to lytic and abortive polyomavirus infection." 03/15/2010 - "Immunohistochemistry using a rabbit polyclonal antibody revealed that large T antigen was expressed in the nuclei of Merkel cell carcinoma cells with Merkel cell polyomavirus infection. " 03/01/2013 - "Merkel cell polyomavirus infection in both components of a combined Merkel cell carcinoma and basal cell carcinoma with ductal differentiation; each component had a similar but different novel Merkel cell polyomavirus large T antigen truncating mutation."
5.	DNA (Deoxyribonucleic Acid)IBA 04/01/2011 - "To investigate polyomavirus infection in wild rodents, we analysed DNA samples from the spleens of 100 wild rodents from Zambia using a broad-spectrum PCR-based assay. " 03/01/2006 - "On the DNA level, presence of a polyomavirus infection was conclusively proved by the polymerase chain reaction using avian polyomavirus (APV)-specific primers. " 03/01/1998 - "In each flock, cause of death was determined to be polyomavirus infection, by means of DNA testing and in situ hybridization. " 05/01/1991 - "A 550-bp product with identical restriction enzyme sites was amplified from a suspected polyomavirus isolated from a peach-faced lovebird (Agapornis pesonata) and from tissue DNA from a Hahn's macaw (Ara nobilis) and a sun conure (Aratinga solstitialis) with histological lesions suggestive of polyomavirus infection. " 01/01/1991 - "Papanicolaou stained smears of urinary sediment containing inclusion bearing urothelial cells suggestive of human polyomavirus infection were destained and reprocessed for in situ hybridization using a biotinylated probe for human polyomavirus DNA. "
6.	Capsid Proteins (Capsid Protein)IBA 06/01/2003 - "The ability to vaccinate against polyomavirus infection in a T-cell deficient as well as a normal immune context was studied using polyomavirus major capsid protein (VP1) pseudocapsids (VP1-ps) or a glutathione-S-transferase-VP1 (GST-VP1) fusion protein. " 12/01/1995 - "In addition, the subcellular location of hsc70 changed from cytoplasmic to nuclear late in polyomavirus infection, coincident with the nuclear localization of the viral capsid proteins. " 05/01/1993 - "During polyomavirus infection the capsid proteins are synthesized in the cytoplasm and transported into the nucleus were virion assembly occurs. " 02/01/2013 - "Common WU polyomavirus infection in a Beijing population indicated by surveillance for serum IgG antibody against capsid protein VP2." 06/01/2012 - "This review deals with these issues, and the potential of the capsid protein VP1 to form virus-like particles for use as vaccines against polyomavirus infections."
7.	CreatinineIBA 12/01/2004 - "All three patients presented with an elevated serum creatinine and demonstrated polyomavirus infection on biopsy and by blood PCR. " 08/15/2009 - "Patients with polyomavirus infection did not have worse renal function than those without infection, but in patients with BKV infection, creatinine clearances were lower at times when viral shedding was detected (P=0.038). " 01/01/2009 - "In November 2006 and March 2007 two graft biopsies were taken because of a significant rise in serum creatinine; they revealed chronic allograft nephropathy and polyomavirus infection. " 02/01/2007 - "Infection with individual polyomaviruses or polyomavirus infection in aggregate was not associated with reduced creatinine clearance. "
8.	AntibodiesIBA 08/01/2008 - "To investigate the seroprevalence of polyomavirus infections in macaques, we analyzed 1579 sera from nine different species for antibodies cross-reactive with simian virus 40 (SV40) in an enzyme-linked immunosorbent assay. " 06/01/2003 - "To assess the stability of polyomavirus antibodies in serial samples over time and the incidence and age-specific prevalence of polyomavirus infections, we established enzyme immunoassays (EIAs) using purified yeast-expressed virus-like particles (VLPs) containing the VP1 major capsid proteins of JC virus (JCV) and the AS and SB strains of BK virus (BKV). " 03/01/1998 - "The importance of antibodies for elimination of polyomavirus infection and the prevention of virus induced oncogenesis was studied, X-linked immunodeficiency (XID) mice, IgM-/- single knockout and IgMI-/- CD8-/- double knockout mice, all defective in antibody production, and normal control mice were infected with polyomavirus as adults. "
9.	cidofovir (Vistide)FDA Link 11/01/2002 - "The role of cidofovir in the treatment of polyomavirus infections is more controversial, but here too, cidofovir represents, to date, the only available efficacious therapeutic modality. " 03/01/1997 - "Thus, HPMPC deserves further evaluation as a candidate drug for polyomavirus infections in the immunocompromised host." 11/01/2002 - "Treatment of polyomavirus infection with cidofovir in a renal-transplant recipient."
10.	MicroRNAs (MicroRNA)IBA 01/01/2013 - "In this review, we summarize the current knowledge of microRNAs involved in polyomavirus infection. " 02/01/2014 - "MicroRNA expression patterns related to merkel cell polyomavirus infection in human merkel cell carcinoma."

Therapies and Procedures

1.	Transplants (Transplant) 03/01/2006 - "The relation between polyomavirus infections and their possible involvement in post-transplant pathologies need further investigation. " 01/01/2004 - "[Recurrent polyomavirus infections in kidney transplants (BK virus nephropathy)]." 11/01/2002 - "Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed." 09/01/2001 - "HUMAN POLYOMAVIRUS INFECTIONS: Polyomavirus BK has been implicated as the pathogenic agent causing tubulointerstitial nephropathies in less than 5% of all kidney graft recipients. " 05/01/1997 - "Contrary to prior reports, our patients have not lost their grafts and continue to have stable, albeit reduced, graft function at 2.5 years and 4.5 years following the initial diagnosis of renal polyomavirus infection."
2.	Transplantation (Transplant Recipients) 01/01/2016 - "Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient." 04/01/2013 - "The results indicate that there is a need to increase the sensitivity of assays used to detect viruses in patients with CDK, especially given that polyomavirus infections, especially BKV, can lead to a loss of kidney function following transplantation." 06/01/2011 - "Prospective study of posttransplant polyomavirus infection in renal transplant recipients." 05/15/2010 - "Treatment of polyomavirus infection in kidney transplant recipients: a systematic review." 07/27/2006 - "Polyomavirus nephropathy in the native kidneys of an unrelated cord blood transplant recipient followed by a disseminated polyomavirus infection."
3.	Homologous Transplantation (Allograft) 08/18/1973 - "Cytological and virological studies on 74 patients with functioning renal allografts were undertaken to detect polyomavirus infection of the renal tract. " 11/01/2015 - "Circular episomal BK-polyomavirus gene sequences are not found, and the renal allograft shows no productive polyomavirus infection or polyomavirus nephropathy. " 11/01/2013 - "Polyomavirus infection in renal allograft." 11/01/2012 - "Severe acute T cell and antibody-mediated rejection in ectopic kidney allografts with or without mouse polyomavirus infection." 01/01/2006 - "Latent and productive polyomavirus infections of renal allografts: morphological, clinical, and pathophysiological aspects."
4.	Kidney Transplantation 06/01/2008 - "Human polyomavirus infection, which can be detected morphologically on Pap-stained routine urine cytology specimens, is most commonly encountered in immunocompromised patients and is a well-described complication of renal transplantation. " 01/01/2008 - "Immunologic control for polyomavirus infection after kidney transplantation." 06/01/2003 - "Renal transplantation and polyomavirus infection: recent clinical facts and controversies." 04/12/2003 - "[Therapeutic possibilities for polyomavirus infections in renal transplantation]." 08/15/2009 - "Polyomavirus infection causes nephropathy after kidney transplantation but has not been thoroughly investigated in nonrenal organ transplantation. "
5.	Organ Transplantation 09/01/2014 - "European perspective on human polyomavirus infection, replication and disease in solid organ transplantation." 02/01/2013 - "Systemical immunosuppression after organ transplantation can lead to reactivation of persistent polyomavirus infections which may cause rejection of the transplanted organ. " 08/15/2009 - "Polyomavirus infection causes nephropathy after kidney transplantation but has not been thoroughly investigated in nonrenal organ transplantation. " 02/01/2007 - "Polyomavirus infection causes renal dysfunction after kidney transplantation, but it has not been thoroughly investigated in nonrenal solid-organ transplantation. "