Excitatory Amino Acid Transporter 2

A glutamate plasma membrane transporter protein found in ASTROCYTES and in the LIVER.

Also Known As:

EAAT-2 Excitatory Amino Acid Transporter; EAAT2 Neurotransmitter Transporter; GLT-1 Transport Protein; GluT-1 Glutamate Transporter; SLC1A2 Transporter; EAAT 2 Excitatory Amino Acid Transporter; GLT 1 Transport Protein; GluT 1 Glutamate Transporter; Glutamate Transporter, GluT-1; Neurotransmitter Transporter, EAAT2; Transport Protein, GLT-1; Transporter, SLC1A2

Networked: 50 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589

Experts

1.	Aschner, Michael: 2 articles (02/2022 - 01/2021)
2.	Lee, Eunsook: 2 articles (02/2022 - 01/2021)
3.	Pajarillo, Edward: 2 articles (02/2022 - 01/2021)
4.	Rizor, Asha: 2 articles (02/2022 - 01/2021)
5.	Son, Deok-Soo: 2 articles (02/2022 - 01/2021)
6.	Ching, Jared: 2 articles (01/2018 - 08/2015)
7.	Xing, Hui Qin: 2 articles (06/2017 - 02/2009)
8.	Fisher, Paul B: 2 articles (01/2015 - 06/2005)
9.	Ludolph, Albert C: 2 articles (06/2008 - 03/2003)
10.	Meyer, Thomas: 2 articles (06/2008 - 03/2003)

Related Diseases

1.	Ciguatera Poisoning (Ciguatera) 06/01/2013 - "The activation of astroglia was further indicated by activation of the gap junction protein connexin 43 and upregulation of excitatory amino acid transporter 2 expression suggesting that glutamate was normally rapidly cleared from the synaptic cleft during acute ciguatera poisoning. "
2.	Schizophrenia (Dementia Praecox) 08/06/2004 - "In this study we report an association study of the excitatory amino acid transporter 2 gene, SLC1A2 with schizophrenia. " 08/06/2004 - "Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia." 01/01/2019 - "Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population." 05/01/1998 - "Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia." 06/01/2011 - "The encoded proteins balance glutamate signalling vs. excitotoxicity in complex interactions involving the excitatory amino acid transporter 2 (EAAT2), implicated in the dysfunctional glutamatergic signalling in schizophrenia. "
3.	Alzheimer Disease (Alzheimer's Disease) 06/01/2008 - "This study investigated the possible relationship between hypoxia and alternative splicing of the excitatory amino acid transporter 2 (EAAT2) in a transgenic model for Alzheimer's disease. " 07/01/2010 - "Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease." 02/01/2022 - "Impairment of the astrocytic glutamate transporter excitatory amino acid transporter 2 (EAAT2) is associated with neurological disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), and manganism, a neurological disorder caused by overexposure to manganese (Mn) which shares the features of sporadic PD. " 01/01/2021 - "Dysregulation of the astrocytic glutamate transporter excitatory amino acid transporter 2 (EAAT2) is associated with several neurological disorders, including Parkinson's disease, Alzheimer's disease, and manganism, the latter induced by chronic exposure to high levels of manganese (Mn). "
4.	Hypoxia (Hypoxemia) 06/01/2008 - "This study investigated the possible relationship between hypoxia and alternative splicing of the excitatory amino acid transporter 2 (EAAT2) in a transgenic model for Alzheimer's disease. " 09/09/2008 - "Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia." 03/15/2003 - "In several models of ischemia-hypoxia, a reduced immunoreactivity and altered RNA expression of excitatory amino acid transporter 2 (EAAT2), the major excitatory amino acid transporter, have been reported. "
5.	Pain (Aches) 10/25/2012 - "In the present study we examined GFAP and excitatory amino acid transporter 2 (EAAT2) protein levels in the periaqueductal gray matter (PAG) after subacute and chronic restraint stresses to clarify changes in descending pain modulatory system in the rat with stress-induced hyperalgesia. " 01/01/2023 - "Further, we found that the expression levels of glutamate transporters, excitatory amino acid transporter 1 (EAAT1), and excitatory amino acid transporter 2 (EAAT2) were increased in the DRG of BTBR mice but decreased after inhibiting Kir4.1. This suggests that Kir4.1 may play a key role in the improvement of pain insensitivity in ASD by regulating glutamate transporters. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Connexin 43 (Connexin43)
3.	Connexins
4.	Proteins (Proteins, Gene)
5.	Amino Acid Transport System X-AG (Glutamate Transporter)
6.	Filamins
7.	Vesicular Glutamate Transport Protein 2
8.	Glycine Plasma Membrane Transport Proteins
9.	Paclitaxel (Taxol)
10.	Transcription Factors (Transcription Factor)