Cationic Amino Acid Transporter 1

A high-affinity, low capacity system y+ amino acid transporter found ubiquitously. It has specificity for the transport of ARGININE; LYSINE; and ORNITHINE. It may also act as an ecotropic leukemia retroviral receptor.

Also Known As:

ATRC1; CAT-1 Transport Protein; SLC7A1 Transporter; Solute Carrier Family 7-(Cationic Amino Acid Transporter, y+ System), Member 1; CAT 1 Transport Protein; CAT 1 Transporter; Transport Protein, CAT-1; Transporter, CAT-1; Transporter, SLC7A1; CAT-1 Transporter

Networked: 21 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Amino Acid Transport Systems: 812
        Basic Amino Acid Transport Systems: 59
        Amino Acid Transport System y+: 1
        Cationic Amino Acid Transporter 1: 21
        human CAT-3 transporter
        human SLC7A1 protein
        mouse Slc7a1 protein
      - Solute Carrier Proteins: 34
        Amino Acid Transport System y+: 1
        Cationic Amino Acid Transporter 1: 21
        human CAT-3 transporter
        human SLC7A1 protein
        mouse Slc7a1 protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Amino Acid Transport Systems: 812
        Basic Amino Acid Transport Systems: 59
        Amino Acid Transport System y+: 1
        Cationic Amino Acid Transporter 1: 21
        human CAT-3 transporter
        human SLC7A1 protein
        mouse Slc7a1 protein
      - Solute Carrier Proteins: 34
        Amino Acid Transport System y+: 1
        Cationic Amino Acid Transporter 1: 21
        human CAT-3 transporter
        human SLC7A1 protein
        mouse Slc7a1 protein

Experts

1.	Han, Junyi: 2 articles (01/2021 - 01/2013)
2.	De Santo, Carmela: 2 articles (01/2019 - 09/2017)
3.	Mussai, Francis: 2 articles (01/2019 - 09/2017)
4.	Vardon, Ashley: 2 articles (01/2019 - 09/2017)
5.	Sobrevia, Luis: 2 articles (10/2013 - 10/2004)
6.	Hatzoglou, Maria: 2 articles (02/2007 - 01/2002)
7.	Wek, Ronald C: 2 articles (02/2007 - 01/2002)
8.	Yaman, Ibrahim: 2 articles (02/2007 - 01/2002)
9.	Arai, Sayaka: 1 article (02/2021)
10.	Endo, Yuichi: 1 article (02/2021)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 05/01/1994 - "In human fibroblasts, porcine pulmonary artery endothelial cells, and cultured rat hepatoma cells, the CAT-1 transporter protein was clustered in an apparent random pattern throughout the plasma membrane. " 01/01/2006 - "Here, we show that cationic amino acid transporter 1 (CAT-1) mRNA and reporters bearing the CAT-1 3'UTR or its fragments can be relieved from the miRNA miR-122-induced inhibition in human hepatoma cells in response to different stress conditions. "
2.	Heart Failure 11/01/2011 - "The aim of this study was to investigate the effect of pharmacological treatment on symmetric dimethylarginine (SDMA), ADMA and arginine plasma concentrations in patients with acute congestive heart failure (ACHF) through the evaluation of type-1 system cationic amino acid transporter-1/type 1 dimethylarginine dimethylaminohydrolases-1 (CAT-1/DDAH-1). "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2021 - "Arginine transporter CAT-1 and Human member 14 of the solute carrier family 6 (SLC6A14) are overexpressed in colorectal cancer cells and contributes to intracellular arginine levels. " 01/01/2021 - "Our quantitative profiling of 6,307 Te-EV proteins and 8,565 tissue proteins from primary colorectal cancer and adjacent normal mucosa (n = 17) allowed identification of a specific cargo in colorectal cancer-derived Te-EVs, high-affinity cationic amino acid transporter 1 (CAT1, P = 5.0 × 10-3, fold change = 6.2), in addition to discovery of a new class of EV markers, VPS family proteins. " 01/01/2013 - "Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue." 02/01/2021 - "We analyzed chromosomal aberrations in a set of 100 human primary colorectal cancers (CRCs) using CGH and found a solute carrier (SLC) 7A1 gene, which encodes cationic amino acid transporter 1 (CAT1) with 14 putative transmembrane domains, in a chromosome region (13q12.3) with a high frequency of gene amplifications. "
4.	Starvation 02/15/2007 - "The arginine/lysine transporter, cat-1, is induced during amino acid starvation by transcriptional and post-transcriptional mechanisms. " 02/15/2007 - "A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation." 01/18/2002 - "Here it is shown that translation of the arginine/lysine transporter cat-1 mRNA increases during amino acid starvation of mammalian cells. "
5.	Neoplasms (Cancer) 05/01/2013 - "Immunohistochemical analysis revealed that the expression levels of cationic amino acid transporter 1 (CAT1), a negative target gene of miR-122, were lower in liver metastases than primary tumors (P < 0.001). " 01/01/2019 - "Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	MicroRNAs (MicroRNA)
3.	3' Untranslated Regions (3' UTR)
4.	Arginine (L-Arginine)
5.	dimethylarginine
6.	symmetric dimethylarginine
7.	Proteins (Proteins, Gene)
8.	Arginase
9.	Nitric Oxide Synthase (NO Synthase)
10.	Amino Acids