HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

DNA Gyrase

A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
Also Known As:
DNA-Gyrase; GyrA Protein; GyrB Protein; DNA Gyrase A Subunit; DNA Gyrase B Subunit
Networked: 119 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Aubry, Alexandra: 10 articles (11/2013 - 04/2004)
2. Sriram, Dharmarajan: 6 articles (02/2016 - 06/2006)
3. Mayer, Claudine: 6 articles (08/2014 - 08/2010)
4. Maxwell, Anthony: 5 articles (01/2018 - 01/2005)
5. Yogeeswari, Perumal: 5 articles (02/2016 - 06/2006)
6. Cambau, Emmanuelle: 5 articles (04/2012 - 04/2004)
7. Jarlier, Vincent: 4 articles (02/2013 - 04/2004)
8. Nagaraja, Valakunja: 4 articles (03/2008 - 01/2005)
9. Bax, Benjamin D: 3 articles (01/2018 - 06/2013)
10. Goyal, Sukriti: 3 articles (01/2018 - 12/2015)

Related Diseases

1. Tuberculosis (Tuberculoses)
2. Gonorrhea
3. Bacterial Infections (Bacterial Infection)
4. Cardiotoxicity
5. Infections

Related Drugs and Biologics

1. Fluoroquinolones
2. Enzymes
3. Quinolones
4. DNA Topoisomerase IV (Topoisomerase IV)
5. DNA (Deoxyribonucleic Acid)
6. Anti-Bacterial Agents (Antibiotics)
7. Ciprofloxacin (Cipro)
8. zoliflodacin
9. DNA Topoisomerases
10. Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1. Treatment Delay