Sodium Channel Blockers

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.

Also Known As:

Sodium Channel Inhibitors; Blocker, Sodium Channel; Channel Blocker, Sodium; Channel Inhibitor, Sodium; Channel Inhibitors, Sodium; Inhibitor, Sodium Channel; Inhibitors, Sodium Channel; Channel Blockers, Sodium; Sodium Channel Blocker; Sodium Channel Inhibitor

Networked: 584 relevant articles (65 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Cardiovascular Agents: 817
      - Sodium Channel Blockers: 584
        Voltage-Gated Sodium Channel Blockers: 27
  - Molecular Mechanisms of Pharmacological Action: 24
    - Membrane Transport Modulators
      - Sodium Channel Blockers: 584
        Voltage-Gated Sodium Channel Blockers: 27
        Acid Sensing Ion Channel Blockers: 11
        Epithelial Sodium Channel Blockers: 8

Experts

1.	Waxman, Stephen G: 12 articles (12/2020 - 08/2004)
2.	Priest, Birgit T: 11 articles (06/2013 - 08/2004)
3.	Kaczorowski, Gregory J: 10 articles (06/2013 - 08/2004)
4.	Desaphy, Jean-François: 8 articles (12/2021 - 02/2013)
5.	Wilde, Arthur A M: 8 articles (01/2021 - 09/2005)
6.	Shimizu, Wataru: 8 articles (01/2012 - 01/2005)
7.	Martin, William J: 8 articles (12/2010 - 08/2004)
8.	Antzelevitch, Charles: 7 articles (01/2020 - 01/2005)
9.	Lyons, Kathryn A: 7 articles (06/2013 - 04/2005)
10.	Møller, Rikke S: 6 articles (11/2022 - 01/2016)

Related Diseases

1.	Seizures (Absence Seizure) 07/01/2020 - "LCM is efficacious and overall well tolerated in children with focal-onset seizures and exhibits higher efficacy with early introduction and when added to a non-sodium channel blocker." 02/01/2022 - "Sodium channel blockers were effective in treating seizures for some SCN8A-related disorders however may not be relevant to the mutant location." 08/01/2018 - "Sodium channel blockers were less effective for patients with SCN1A mutations and SCN2A mutations with early seizures onset. " 01/01/2023 - "Alternatively, non-DS/non-GEFS+ phenotypes might be associated with gain of channel function, and sodium channel blockers could control seizures by counteracting excessive channel function. " 01/01/2023 - "Sodium channel blockers never worsened seizures, and 50% of patients experienced long periods of seizure freedom. "
2.	Neuralgia (Stump Neuralgia) 01/01/2001 - "Sodium channel blockers have been reported to be effective in relieving neuropathic pain. " 01/01/2019 - "Natural toxins and developing subtype-specific and molecular-specific sodium channel blockers show promise for treatment of neuropathic pain with minimal side effects. " 08/01/2017 - "Recently, it was discovered that this compound is also an efficient sodium channel blocker with potent anti-neuropathic pain properties. " 01/01/2016 - "This review covers the most recent publications regarding sodium channel blockers and their development as new treatments for neuropathic pain. " 06/15/2013 - "A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain."
3.	Pain (Aches) 01/01/2008 - "Sodium channel blockers can be effective in the treatment of pain. " 01/01/2018 - "It is an evidence update for clinical use of sodium channel blockers, clarifies misconceptions regarding their use, and highlights emerging research for improved pain targets that justifies additional study. " 06/08/2010 - "Our data suggest that ranalozine can attenuate hyperexcitability of DRG neurons over-expressing wild-type Nav1.7 channels, as occurs in acquired neuropathic and inflammatory pain, and thus merits further study as an alternative to existing non-selective sodium channel blockers." 04/01/2023 - "Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker." 10/01/2021 - "BW-031 is a novel cationic sodium channel inhibitor that can be applied locally as a single agent to inhibit inflammatory pain. "
4.	Epilepsy (Aura) 11/01/2021 - "Sodium channel blockers are effective for benign infantile epilepsy." 05/01/2017 - "In contrast, sodium channel blockers were rarely effective in epilepsies with later onset (≥3 months) and sometimes induced seizure worsening. " 01/01/2023 - "This study aims to evaluate the effectiveness and tolerability of LCM when used in the immediate switch from sodium channel blockers in patients with focal-onset and generalized-onset epilepsies. " 08/01/2022 - "This study supports the notion that individuals with MS + E can have more severe epilepsy than those with E - MS. Seizure severity among individuals with MS + E treated with sodium channel blockers/modulators vs other ASM classes shows no significant differences. " 10/01/2019 - "The objective of this study was to examine the relationship between adherence to treatment with sodium channel blockers (SCBs) and health-related quality of life (HRQoL), work productivity and activity impairment (WPAI), healthcare resource utilization (HRU), and associated costs among patients with epilepsy. "
5.	Brain Diseases (Brain Disorder) 02/01/2021 - "Sodium channel blockers are effective in seizure control in these patients with KCNQ2 encephalopathy. " 02/01/2021 - "Early recognition of KCNQ2 encephalopathy and early use of sodium channel blockers might be helpful in seizure control." 04/01/2017 - "Sodium channel blockers represent the first-line treatment for confirmed or suspected SCN2A-related epileptic encephalopathies. " 09/01/2018 - "FGF12-related epileptic encephalopathy may exhibit diverse phenotypes and may respond to sodium channel blockers or high-dose PB." 10/01/2020 - "We aimed to delineate the phenotypic spectrum of SCN2A-related developmental and epileptic encephalopathy (DEE) and determine the effectiveness of various treatment modalities, including sodium channel blockers and the ketogenic diet. "

Related Drugs and Biologics

1.	Mexiletine (Mexitil)
2.	Phenytoin (Dilantin)
3.	Carbamazepine (Tegretol)
4.	Lidocaine (Xylocaine)
5.	Lamotrigine (Lamictal)
6.	Sodium Channels (Sodium Channel)
7.	Anticonvulsants (Antiepileptic Drugs)
8.	Oxcarbazepine (Trileptal)
9.	Riluzole
10.	Sodium Channel Blockers

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Ketogenic Diet
4.	Analgesia
5.	Topical Administration