Amino Acid Transport System A

A sodium-dependent neutral amino acid transporter that accounts for most of the sodium-dependent neutral amino acid uptake by mammalian cells. The preferred substrates for this transporter system include ALANINE; SERINE; and GLUTAMINE.

Also Known As:

Networked: 18 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jansson, Thomas: 2 articles (01/2021 - 01/2021)
2.	Powell, Theresa L: 2 articles (01/2021 - 01/2021)
3.	Ganapathy, V: 2 articles (02/2003 - 05/2001)
4.	Alkhalefah, Alaa: 1 article (11/2021)
5.	Allwood, James W: 1 article (11/2021)
6.	Ashton, Nick: 1 article (11/2021)
7.	Dunn, Warwick B: 1 article (11/2021)
8.	Glazier, Jocelyn D: 1 article (11/2021)
9.	Houghton, Franchesca D: 1 article (11/2021)
10.	Parry, Kate L: 1 article (11/2021)

Related Diseases

1.	Neoplasms (Cancer) 07/12/2013 - "SNAT1 is a subtype of the amino acid transport system A that has been implicated to play a potential role in cancer development and progression, yet its role in breast cancer remains unclear. " 01/01/2017 - "These results indicate that the activity of energy dependent System-A transporter may reflect the therapeutic efficacy of carbon-ion radiotherapy and suggests that longer half-life radionuclide-labeled probes for System-A may also provide widely available probes to evaluate the effects of particle radiotherapy on tumors at early stage of the treatment."
2.	Hyperalgesia 04/17/2012 - "These findings suggest that amino acid transport system A is involved in inflammation-induced nociception, and inhibition of this transporter system results in inhibition of the central sensitization and hyperalgesia." 04/17/2012 - "The current study investigated the role of amino acid transport system A in central sensitization and hyperalgesia induced by intraplantar injection of formalin in rats. "
3.	Sepsis (Septicemia) 04/01/1990 - "Effect of sepsis on amino acid transport system A and its response to insulin in incubated rat skeletal muscle." 04/01/1986 - "The results suggest that sepsis leads to marked impairment of amino acid transport system A in muscle and that this impairment is mediated by a circulating factor that is not endotoxin. " 04/01/1990 - "The lowest hormone concentration tested that significantly enhanced MeAIB uptake in nonseptic muscle was 10(2) microU/mL and in septic muscle 10 microU/mL. The results suggest that sepsis in rats specifically inhibits amino acid transport system A and that reduced muscle amino acid uptake may be caused by a circulating factor in sepsis.(ABSTRACT TRUNCATED AT 250 WORDS)"
4.	Starvation 04/18/2005 - "We reported here the functional characteristics of Na+ -dependent neutral amino acid transport system A in normal human astrocytes and its adaptive regulation, a process in which amino acid starvation induces the transport activity. " 05/02/2001 - "We investigated the molecular mechanism involved in the adaptive regulation of the amino acid transport system A, a process in which amino acid starvation induces the transport activity. "
5.	Fetal Growth Retardation (Intrauterine Growth Retardation) 11/01/2021 - "Reduced placental system A transporter activity may be responsible for fetal growth restriction in both sexes." 08/01/1996 - "We conclude that the system A transporter is present in the maternal facing plasma membrane of rat syncytiotrophoblast, but that the activity of this system, per mg of vesicle protein, is unaffected in fetal growth restriction induced by a decrease in maternal placental blood flow in late pregnancy."

Related Drugs and Biologics

1.	Radioisotopes (Radionuclides)
2.	Formaldehyde (Formol)
3.	Proteins (Proteins, Gene)
4.	Amino Acids
5.	2,2-dimethyl-beta-alanine
6.	Amino Acid Transport System L
7.	Peptide Elongation Factor 2 (EF-2)
8.	Messenger RNA (mRNA)
9.	Phospholipids (Phosphatides)
10.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)

Related Therapies and Procedures

1.	Heavy Ion Radiotherapy
2.	Radiotherapy