Membrane Transport Proteins (Biological Pump)

Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.

Also Known As:

Networked: 165 relevant articles (5 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Ying: 5 articles (04/2009 - 06/2004)
2.	Sadée, Wolfgang: 4 articles (04/2009 - 06/2004)
3.	Nies, Anne T: 3 articles (08/2007 - 11/2003)
4.	Liu, Wei: 2 articles (11/2012 - 08/2006)
5.	Giacomini, K M: 2 articles (01/2010 - 03/2007)
6.	Martin, Rowena E: 2 articles (11/2009 - 01/2005)
7.	Kirk, Kiaran: 2 articles (11/2009 - 01/2005)
8.	Lee, Tae-Bum: 2 articles (10/2009 - 01/2008)
9.	Choi, Cheol-Hee: 2 articles (10/2009 - 01/2008)
10.	Landfear, Scott M: 2 articles (07/2009 - 08/2006)

Related Diseases

1.	Drug Toxicity (Drug Safety) 02/01/2011 - "Membrane transporters are important determinants of in vivo drug disposition, therapeutic efficacy and adverse drug reactions. " 01/01/2014 - "Although the mechanism responsible for its therapeutic action is unknown, MTX membrane transport proteins (influx and/or efflux) can be major determinants of pharmacokinetics, adverse drug reactions and clinical response profiles. " 10/01/2012 - "Membrane transporters govern the movement of drugs and their metabolites across biological membranes, thereby determining their pharmacokinetics, efficacy and adverse drug reactions. " 01/01/2012 - "Discovering and contextualizing the contribution of membrane transporters to drug toxicity is a significant new challenge. " 01/01/2010 - "The US Food and Drug Administration-led Critical Path Initiative, launched in 2004, has resulted in an array of activities focused on the sciences that support the development of human medical products.(1) These activities include the development of new scientific tools, such as in vitro testing, qualified biomarkers of drug safety, and innovative new methods in study design and data analysis.(2) As a result of the Critical Path Initiative and enormous advances in the field of membrane transporters, the International Transporter Consortium was formed."
2.	Pain (Aches) 11/30/2002 - "Intrathecal grafting of cells as biological pumps to deliver monoamines, endorphins, and/or trophic factors, has been shown to be effective in treating chronic pain both in experimental animals and in clinical trials. "
3.	Cholestasis 04/15/2011 - "This included genes implicated in early stress responses, regenerative processes, inflammation with inflammatory cell immigration, fibrotic processes, and cholestasis encompassing deregulation of certain membrane transporters. " 01/01/2015 - "Levels of bile acid metabolic enzymes and membrane transporters have been reported to change in cholestasis. " 02/08/2005 - "Gene expression analysis of the BDL knockout animals demonstrated that, in response to cholestasis, PXR and CAR both repressed and induced the specific hepatic membrane transporters Oatp-c (organic anion transporting polypeptide C) and Oatp2 (Na+-dependent organic anion transporter 2), respectively. " 06/01/2003 - "Interplay between these cytokines and a series of hepatocyte membrane transporters appears to result in the cholestasis. " 08/01/2002 - "Rats with ethinyl estradiol-induced cholestasis have a decreased bile flow and a decreased expression of basolateral and canalicular hepatocyte membrane transporters. "
4.	Breast Neoplasms (Breast Cancer) 04/01/2005 - "Breast cancer resistance protein (BCRP) was identified 7 years ago as the most recent member of ABC drug efflux membrane transporters. " 08/01/2008 - "Major role of some members of the ATP-binding cassette (ABC) family of membrane transporters including MDR1 (ABCB1, P-glycoprotein) and breast cancer resistant protein (BCRP, ABCG2) is protection against environmental toxins. " 02/03/2012 - "We found that nifurtimox appeared to use several membrane transporters, in particular breast-cancer resistance protein (BCRP), to exit the BBB cells. " 02/01/2012 - "Membrane transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are efflux pumps that remove drugs from the brain back to the peripheral blood compartment, serving as a functional component of the blood-brain barrier (BBB). " 10/01/2004 - "Breast cancer resistance protein (BCRP), discovered in 1998, is a novel member of ATP-binding cassette (ABC) membrane transporters superfamily. "
5.	Infection 04/01/1986 - "The possibilities in utilizing active transport permeases to direct drugs to the desired receptor are an obvious reality, and will undoubtedly lead to new methods for treating bacterial, fungal or even viral infections, and for improved ways of presenting anti-tumour agents. " 10/01/2003 - "Eukaryotic Nramp genes encode divalent metal ion permeases important for nutrition and resistance to microbial infection. " 12/01/2008 - "Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection." 07/20/2010 - "Multidrug membrane transporters (efflux pumps) in both prokaryotes and eukaryotes are responsible for impossible treatments of a wide variety of diseases, including infections and cancer, underscoring the importance of better understanding of their structures and functions for the design of effective therapies. " 04/01/2012 - "A mutant strain lacking both permeases, ΔfpuBΔfatCD, was incapable of using petrobactin as an iron source and exhibited attenuated virulence in a murine model of inhalational anthrax infection. "

Related Drugs and Biologics

1.	Endorphins
2.	Adenosine Triphosphate (ATP)
3.	Bile Acids and Salts (Bile Acids)
4.	Ursodeoxycholic Acid (Urso)
5.	Enzymes
6.	Messenger RNA (mRNA)
7.	Biological Markers (Surrogate Marker)
8.	Sulindac (Copal)
9.	Platinum
10.	Homocysteine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
3.	Heterologous Transplantation (Xenotransplantation)