Isoaspartic Acid (Isoaspartate)

An ASPARTIC ACID residue in polypeptide chains that is linked at the beta-carboxyl group instead of at the normal, alpha-carboxyl group, polypeptide linkage. It is a result of the spontaneous decomposition of aspartic acid or ASPARAGINE residues.

Also Known As:

Networked: 33 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Corti, Angelo: 4 articles (09/2017 - 09/2008)
2.	Curnis, Flavio: 4 articles (09/2017 - 09/2008)
3.	Qin, Zhenxia: 3 articles (11/2021 - 01/2012)
4.	Sacchi, Angelina: 3 articles (09/2017 - 09/2008)
5.	Aswad, Dana W: 3 articles (03/2014 - 03/2006)
6.	Shimizu, Takahiko: 3 articles (09/2005 - 08/2002)
7.	Shirasawa, Takuji: 3 articles (09/2005 - 08/2002)
8.	Niisato, Miyuki: 2 articles (03/2018 - 04/2016)
9.	Ogasawara, Masahito: 2 articles (03/2018 - 04/2016)
10.	Saito, Heisuke: 2 articles (03/2018 - 04/2016)

Related Diseases

1.	Neoplasms (Cancer) 09/26/2017 - "Glycine N-methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing." 09/01/2008 - "Isoaspartate-glycine-arginine: a new tumor vasculature-targeting motif." 04/01/2021 - "Theses reviewed in this issue include "An Aging Tug of War: The Accumulation of the Spontaneous L-Isoaspartate Modification in Proteins vs. Canonical and Novel Maintenance Pathways," "Cellular and Molecular Mechanisms Underpinning Microglial Activation During Remyelination," "Early Detection of Cancer Metastasis at a Synthetic Pre-Metastatic Niche Using Inverse Spectroscopic Optical Coherence Tomography," "Magnetic Stem Cell Spheroid Microrobots and Their In Vivo Applications," "Reprogramming Human Endothelium to Hematopoietic Stem Cells with Adaptive Immune Function," and "Scaffold-Free Three-Dimensional Bioprints Repair Small Intestine Injuries and Integrate Into Native Intestine."" 03/19/2010 - "Recent studies have shown that compounds containing this motif can rapidly deamidate and generate isoaspartate-glycine-arginine (isoDGR), a ligand of alphavbeta3-integrin that can be also exploited for drug delivery to tumors. " 08/01/2022 - "Protein-L-isoaspartate O-methyltransferase-1 (PCMT1) is a protein carboxyl methyltransferase enzyme, which has been found to play roles in cancers. "
2.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/01/2008 - "Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene."
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2023 - "Testing the link between isoaspartate and Alzheimer's disease etiology." 11/14/2020 - "Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology." 09/15/2000 - "Isoaspartate formation and neurodegeneration in Alzheimer's disease." 11/01/2002 - "Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease." 01/01/2018 - "Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer's disease."
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2021 - "Aging leads to the formation of abnormal isoaspartate (isoAsp) residues from isomerization of normal aspartates in proteins, triggering fibril formation that leads to neurodegenerative diseases. " 01/01/2012 - "To extend this finding and explore its possible relevance to neurodegenerative diseases, we attempted to determine the stoichiometry of isoaspartate accumulation in synuclein in vivo and in vitro. " 11/01/2021 - "Protein l-isoaspartyl methyltransferase (PIMT/PCMT1), an enzyme repairing isoaspartate residues in peptides and proteins that result from the spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues during aging, has been revealed to be involved in neurodegenerative diseases (NDDs) and diabetes. " 11/01/2023 - "Synaptic dysfunction is a typical pathophysiologic change in neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), Hintington's disease (HD) and amyotrophic lateral sclerosis (ALS), which involves protein post-translational modifications (PTMs) including L-isoaspartate (L-isoAsp) formed by isomerization of aspartate or deamidation of asparagine. "
5.	Amyloid Plaque 07/08/2023 - "The amyloid plaques contain various Aβ isoforms, among which the most common is Aβ with an isoaspartate in position 7 (isoD7). " 11/01/2002 - "Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease." 09/01/2005 - "Specific antibodies recognizing isoaspartate of Abeta revealed that isomerized Abeta peptides were deposited in senile plaques as well as amyloid-bearing vessels. "

Related Drugs and Biologics

1.	Glycine (Aminoacetic Acid)
2.	Arginine (L-Arginine)
3.	Ligands
4.	Proteins (Proteins, Gene)
5.	Enzymes
6.	Protein D-Aspartate-L-Isoaspartate Methyltransferase (Protein L Isoaspartate D Aspartate O Methyltransferase)
7.	Asparagine
8.	Methyltransferases
9.	Aspartic Acid (Aspartate)
10.	Amyloid beta-Peptides