Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)

A LDL-receptor related protein involved in clearance of chylomicron remnants and of activated ALPHA-MACROGLOBULINS from plasma.

Also Known As:

LDL-Receptor Related Protein; Antigens, CD91; Apo E Receptor; ApoE Receptor; CD91 Antigen; Receptor, Apo E; alpha2-Macroglobulin Signaling Receptor; Antigen, CD91; CD91 Antigens; LDL Receptor Related Protein; LDL Receptor Related Protein 1; Low Density Lipoprotein Receptor Related Protein 1; Receptor, ApoE; alpha 2 Macroglobulin Receptor; alpha-2 Macroglobulin Receptor; alpha2 Macroglobulin Signaling Receptor; Apolipoprotein E Receptor; LDL-Receptor Related Protein 1; Receptor, Apolipoprotein E; Receptor, alpha-2 Macroglobulin; alpha-2-Macroglobulin Receptor

Networked: 339 relevant articles (15 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Herz, Joachim: 8 articles (01/2018 - 10/2002)
2.	Llorente-Cortés, Vicenta: 8 articles (08/2015 - 03/2005)
3.	Badimon, Lina: 7 articles (08/2015 - 03/2005)
4.	Bu, Guojun: 7 articles (01/2014 - 09/2007)
5.	Fazio, Sergio: 6 articles (01/2022 - 03/2007)
6.	Zlokovic, Berislav V: 6 articles (10/2012 - 11/2004)
7.	Mani, Arya: 5 articles (10/2019 - 11/2008)
8.	Deane, Rashid: 5 articles (10/2012 - 11/2004)
9.	Tavori, Hagai: 4 articles (01/2022 - 01/2016)
10.	Strickland, Dudley K: 4 articles (01/2021 - 03/2013)

Related Diseases

1.	Neoplasms (Cancer) 07/14/2010 - "The low-density lipoprotein receptor-related protein-1 (LRP-1) is an endocytic receptor mediating the clearance of various extracellular molecules involved in the dissemination of cancer cells. " 04/01/2019 - "Low-density lipoprotein receptor-Related Protein-1 (LRP-1) has been reported to involve in tumor development. " 01/06/2016 - "Roles of low-density lipoprotein receptor-related protein 1 in tumors." 01/01/2016 - "The low-density lipoprotein receptor-related protein 1 (LRP-1) is a multiligand endocytic receptor, which plays a pivotal role in controlling cytoskeleton dynamics during cancer cell migration. " 11/01/2011 - "There was no correlation between low-density lipoprotein receptor-related protein 1 expression and survival, but a trend was found between low-density lipoprotein receptor-related protein 1 overexpression and tumor recurrence. "
2.	Alzheimer Disease (Alzheimer's Disease) 12/01/2020 - "The Alzheimer disease-associated multifunctional low-density lipoprotein receptor-related protein-1 is expressed in the brain. " 01/01/2020 - "Low-density lipoprotein receptor-related protein 1 (LRP1) and tau play an important role in developing Alzheimer's disease. " 01/01/2017 - "Low density lipoprotein receptor-related protein 1 (LRP1) C766T polymorphism (rs1799986) has been extensively investigated for Alzheimer's disease (AD) susceptibility. " 05/01/2014 - "Apolipoprotein E receptor pathways in Alzheimer disease." 12/01/2010 - "Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain."
3.	Hypertriglyceridemia 02/01/1987 - "These results support the interpretation that delayed chylomicron remnant clearance in subjects with endogenous hypertriglyceridemia may be largely secondary to overproduction of VLDL particles, whose remnants compete with chylomicron remnants for removal by the liver via apoE receptor-mediated endocytosis. " 01/01/2016 - "The hypertriglyceridemia is a disorder of transformation in blood of phylogenetically late insulin-dependent palmitic and oleinic lipoproteins of very low density and receptor apoE/B-100-endocytosis by cells of non-ligand lipoproteins of very low density. " 02/01/2013 - "Chronic kidney disease (CKD) results in hypertriglyceridemia which is largely due to impaired clearance of triglyceride-rich lipoproteins occasioned by downregulation of lipoprotein lipase and very low-density lipoprotein (LDL) receptor in the skeletal muscle and adipose tissue and of hepatic lipase and LDL receptor-related protein in the liver. " 07/01/2004 - "The metabolic flow of lipoproteins in normo- and hypertriglyceridemia can be described by separate compartments that contribute to lipoprotein interaction with at least six different receptors: 1) low density lipoprotein (LDL) receptor; 2) LDL receptor-related protein (LRP); 3) apoB(48) macrophage receptor for hypertriglyceridemic very low density lipoproteins (VLDL); 4) scavenger receptors; 5) VLDL receptor; 6) lipolysis-stimulated receptor. " 11/01/2009 - "Hypertriglyceridemia, abnormal composition, and impaired clearance of triglyceride-rich lipoproteins and their remnants are mediated by down-regulation of lipoprotein lipase, hepatic lipase, very low-density lipoprotein (VLDL) receptor, and LDL receptor-related protein, relative reduction in ApoC-II/ApoC-III ratio, up-regulation of acyl-CoA cholesterol acyltransferase, and elevated plasma level of cholesterol ester-poor prebeta HDL. "
4.	Inflammation (Inflammations) 03/08/2023 - "Interestingly, the ability of AMP-IBP5 to alleviate inflammation and improve skin barrier function in AD mice was abolished in mice treated with an antagonist of the low-density lipoprotein receptor-related protein-1 (LRP1) receptor. " 01/11/2023 - "Inflammation-associated low-density lipoprotein receptor-related protein-1 (LRP1) has been validated to be a surrogate target for imaging epileptic foci. " 01/01/2019 - "Novel apoE receptor mimetics reduce LPS-induced microglial inflammation." 10/01/2018 - "Low-density lipoprotein receptor-related protein 1 attenuates house dust mite-induced eosinophilic airway inflammation by suppressing dendritic cell-mediated adaptive immune responses." 07/01/2015 - "Low-density lipoprotein receptor-related protein 1 (LRP1) is known to regulate cell survival and inflammation. "
5.	Abdominal Aortic Aneurysm 02/01/2017 - "Low-density lipoprotein receptor-related protein-1 (LRP1) has been suggested to be a crucial regulator in the pathogenesis of abdominal aortic aneurysm (AAA) from previous genome association and animal studies. " 10/01/2015 - "Plasma Low-density Lipoprotein Receptor-related Protein 1 Concentration is not Associated with Human Abdominal Aortic Aneurysm Presence." 11/01/2014 - "An association between rs1466535 low density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and abdominal aortic aneurysm (AAA) was recently demonstrated. " 11/01/2013 - "There are no published data on the expression of low-density lipoprotein receptor-related protein 1 (LRP1) in human aortic tissues with abdominal aortic aneurysm (AAA), although some researchers have suggested that LRP1 may be a crucial regulator in the pathogenesis of AAA. " 11/01/2013 - "A pilot study on low-density lipoprotein receptor-related protein-1 in Chinese patients with abdominal aortic aneurysm."

Related Drugs and Biologics

1.	Amyloid beta-Peptides
2.	Apolipoproteins E (ApoE)
3.	VLDL Lipoproteins
4.	Lipoproteins (Lipoprotein)
5.	Lipoprotein Lipase (Diacylglycerol Lipase)
6.	Peptide Hydrolases (Proteases)
7.	Triglycerides (Triacylglycerol)
8.	Lipase (Acid Lipase)
9.	Proteins (Proteins, Gene)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Electroacupuncture
2.	Therapeutics
3.	Enzyme Replacement Therapy
4.	Neoadjuvant Therapy
5.	Radiotherapy