LDL-Receptor Related Protein 1 (LDL-Receptor Related Protein)

A LDL-receptor related protein involved in clearance of chylomicron remnants and of activated ALPHA-MACROGLOBULINS from plasma.
Also Known As:
LDL-Receptor Related Protein; Apo E Receptor; ApoE Receptor; Low Density Lipoprotein Receptor-Related Protein; Low-Density-Lipoprotein Receptor-Related Protein-1; Receptor, Apo E; alpha2-Macroglobulin Signaling Receptor; LDL Receptor Related Protein; LDL Receptor Related Protein 1; Receptor, ApoE; Receptor-Related Protein-1, Low-Density-Lipoprotein; alpha 2 Macroglobulin Receptor; alpha-2 Macroglobulin Receptor; alpha2 Macroglobulin Signaling Receptor; Apolipoprotein E Receptor; Receptor, Apolipoprotein E; Receptor, alpha-2 Macroglobulin; alpha-2-Macroglobulin Receptor
Networked: 374 relevant articles (14 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Badimon, Lina: 9 articles (08/2015 - 06/2008)
2. Bu, Guojun: 9 articles (01/2014 - 01/2004)
3. Llorente-Cortés, Vicenta: 8 articles (08/2015 - 06/2008)
4. Zlokovic, Berislav V: 7 articles (10/2012 - 08/2004)
5. Deane, Rashid: 6 articles (10/2012 - 08/2004)
6. Strickland, Dudley K: 5 articles (07/2015 - 07/2002)
7. Cal, Roi: 4 articles (08/2015 - 10/2011)
8. Emonard, Hervé: 4 articles (01/2015 - 12/2004)
9. Erickson, Michelle A: 4 articles (12/2014 - 12/2010)
10. Hyman, Bradley T: 4 articles (03/2013 - 07/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Alzheimer Disease (Alzheimer's Disease)
3. Hypertriglyceridemia
02/01/1987 - "These results support the interpretation that delayed chylomicron remnant clearance in subjects with endogenous hypertriglyceridemia may be largely secondary to overproduction of VLDL particles, whose remnants compete with chylomicron remnants for removal by the liver via apoE receptor-mediated endocytosis. "
02/01/2013 - "Chronic kidney disease (CKD) results in hypertriglyceridemia which is largely due to impaired clearance of triglyceride-rich lipoproteins occasioned by downregulation of lipoprotein lipase and very low-density lipoprotein (LDL) receptor in the skeletal muscle and adipose tissue and of hepatic lipase and LDL receptor-related protein in the liver. "
07/01/2004 - "The metabolic flow of lipoproteins in normo- and hypertriglyceridemia can be described by separate compartments that contribute to lipoprotein interaction with at least six different receptors: 1) low density lipoprotein (LDL) receptor; 2) LDL receptor-related protein (LRP); 3) apoB(48) macrophage receptor for hypertriglyceridemic very low density lipoproteins (VLDL); 4) scavenger receptors; 5) VLDL receptor; 6) lipolysis-stimulated receptor. "
11/01/2009 - "Hypertriglyceridemia, abnormal composition, and impaired clearance of triglyceride-rich lipoproteins and their remnants are mediated by down-regulation of lipoprotein lipase, hepatic lipase, very low-density lipoprotein (VLDL) receptor, and LDL receptor-related protein, relative reduction in ApoC-II/ApoC-III ratio, up-regulation of acyl-CoA cholesterol acyltransferase, and elevated plasma level of cholesterol ester-poor prebeta HDL. "
4. von Willebrand Diseases (von Willebrand's Disease)
5. Atherosclerosis

Related Drugs and Biologics

1. Peptide Hydrolases (Proteases)
2. Lipoproteins (Lipoprotein)
3. alpha-Macroglobulins (alpha 2 Macroglobulin)
4. Amyloid (Amyloid Fibrils)
5. Lipoprotein Lipase (Diacylglycerol Lipase)
6. Lipase (Acid Lipase)
7. LDL Receptors (LDL Receptor)
8. Apolipoproteins E (ApoE)
9. Angiopep-2
10. Factor VIII (Coagulation Factor VIII)

Related Therapies and Procedures

1. Electroacupuncture
2. Therapeutics
3. Photochemotherapy (Photodynamic Therapy)
4. Intravenous Injections
5. Drug Therapy (Chemotherapy)