Reactive Nitrogen Species

Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.

Also Known As:

Networked: 418 relevant articles (3 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ichinose, M: 6 articles (12/2009 - 08/2000)
2.	Traber, Daniel L: 5 articles (12/2012 - 08/2008)
3.	Sugiura, Hisatoshi: 5 articles (04/2012 - 01/2004)
4.	Sugiura, H: 5 articles (12/2009 - 08/2000)
5.	Hazen, Stanley L: 5 articles (06/2006 - 06/2002)
6.	Enkhbaatar, Perenlei: 4 articles (12/2012 - 02/2011)
7.	Traber, Lillian D: 4 articles (12/2012 - 02/2011)
8.	Butterfield, D Allan: 4 articles (12/2012 - 05/2004)
9.	Ichinose, Masakazu: 4 articles (04/2012 - 01/2004)
10.	Erzurum, Serpil C: 4 articles (11/2011 - 08/2003)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2015 - "From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species." 01/01/2014 - "Under many inflammatory contexts, such as tumor progression, systemic and peripheral immune response is tailored by reactive nitrogen species (RNS)-dependent post-translational modifications, suggesting a biological function for these chemical alterations. " 01/01/2014 - "The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment." 10/15/2013 - "Fortunately, numerous antioxidant agents are clinically available, and we further propose that the pharmacologic attenuation of these inflammatory processes, particularly the reactive nitrogen species, will restore the cancer cells to an apoptosis-permissive and growth-inhibitory state. " 08/06/2013 - "As cancer cells are particularly sensitive to nitrosative stress, these data open another path for therapies capitalizing on the ability of reactive nitrogen species to induce autophagy-mediated cell death. "
2.	Lung Injury 05/01/2015 - "However, reactive nitrogen species produced by NO can cause lung injury. " 03/01/2015 - "Reactive nitrogen species (RNS) generated after exposure to radiation have been implicated in lung injury. " 08/01/2010 - "Macrophages, reactive nitrogen species, and lung injury." 05/01/2001 - "These results suggest that during restitution after pulmonary injury, epithelium may be sensitive to cell death by reactive nitrogen species." 10/01/2015 - "The single application of bSOD (15 mg/kg) ameliorates radiation-induced lung injury through suppression of reactive oxygen species/reactive nitrogen species or ROS/RNS-dependent tissue damage."
3.	Stomach Neoplasms (Stomach Cancer) 12/01/1998 - "The ability of plant phenolics to scavenge reactive nitrogen species derived from acidic nitrite may contribute to the protective effects of tea polyphenols against gastric cancer."
4.	Inflammation 03/01/2013 - "This radical has many potential biological targets and its concentration, like that of NO and other reactive nitrogen species, is thought to be elevated at sites of inflammation. " 07/01/2011 - "Both inflammation and oxidation may be involved in NEC pathogenesis through reactive nitrogen species production, protein oxidation, and DNA damage. " 05/01/2010 - "Evidences suggest that reactive nitrogen species such as nitrite/nitrate and halogenated oxidant-HOCl accumulate at the site of inflammation. " 05/01/2010 - "Reactive nitrogen species have been implicated in the pathogenesis of over 40 human diseases, including inflammation. " 04/01/2006 - "Therefore, it is considered that excessive amounts of reactive nitrogen species produced via iNOS during chronic inflammation may play a key role in carcinogenesis by causing DNA damage. "
5.	Reperfusion Injury 07/01/2003 - "The purpose of the study was to examine the role of this reactive nitrogen species in lung ischemia-reperfusion injury. " 07/01/2003 - "Critical role of reactive nitrogen species in lung ischemia-reperfusion injury." 01/01/2013 - "Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury." 09/01/2012 - "The pathogenesis of ischemia/reperfusion injury depends on many factors, among them, reactive nitrogen species (RNS) and reactive oxygen species (ROS) are considered as initiators of the injury. " 06/01/2012 - "Peroxynitrite, a reactive nitrogen species, has been implicated in the development of ischemia-reperfusion injury. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Antioxidants
3.	Tea
4.	polyphenols
5.	Peroxynitrous Acid (Peroxynitrite)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	3-nitrotyrosine
8.	Proteins (Proteins, Gene)
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Interleukin-10 (Interleukin 10)

Related Therapies and Procedures

1.	Chemoprevention
2.	Lasers (Laser)
3.	Resuscitation
4.	Transplants (Transplant)
5.	Islets of Langerhans Transplantation