Singlet Oxygen

An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.

Also Known As:

Networked: 601 relevant articles (10 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chignell, Colin F: 7 articles (07/2010 - 01/2005)
2.	Ehrenberg, Benjamin: 6 articles (07/2014 - 04/2002)
3.	Zhao, Baozhong: 6 articles (07/2010 - 02/2007)
4.	Bauer, Georg: 5 articles (12/2015 - 07/2012)
5.	Hasan, Tayyaba: 5 articles (09/2014 - 05/2008)
6.	Zheng, Gang: 5 articles (08/2014 - 07/2004)
7.	Patrice, Thierry: 5 articles (02/2013 - 10/2009)
8.	He, Yu-Ying: 5 articles (07/2010 - 05/2008)
9.	Bilski, Piotr J: 5 articles (07/2010 - 05/2008)
10.	Ohulchanskyy, Tymish Y: 4 articles (08/2015 - 07/2003)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2011 - "The β-substituted dihydroxychlorin products exhibit a strong absorption in the red spectral region, a high singlet oxygen quantum yield, and were found to be highly effective in in vitro assays against HT-29 tumor cells." 04/15/2001 - "Because singlet oxygen introduces lipid hydroperoxides into cell membranes, we hypothesized that PhGPx would provide protection against the oxidative stress of singlet oxygen and therefore could interfere with cancer treatment. " 05/05/2015 - "In a cell culture system, the cytotoxicity of the HPhA/PCAR nanocomplex toward cancer cells was greatly enhanced due to the efficient generation of singlet oxygen under light irradiation; this finding implies that the scavenging activity of PCAR can be restricted to intracellular environments. " 05/05/2015 - "This nanocomplex was designed to improve the water solubility and tumor specificity of PhA and to only release singlet oxygen at the tumor cell. " 04/27/2015 - "Remarkably, the designed photosensitizer can discriminate between different concentrations of GSH in normal and cancer cells and thus remains inefficient as a photosensitizer inside a normal cell while being transformed into a lethal singlet oxygen source in cancer cells. "
2.	Photosensitivity Disorders (Photodermatitis) 10/09/2014 - "It is generally accepted that commonly used PSs generate singlet oxygen ((1)O2) as the cell-toxic species via type II photosensitization. " 11/18/2013 - "Photosensitization of singlet oxygen and in vivo photodynamic therapeutic effects mediated by PEGylated W(18)O(49) nanowires." 11/01/2013 - "The formation of such aggregates is believed to change the main oxidative mechanism from Type-II (singlet oxygen) to Type-I (free radical) photosensitization. " 08/01/2013 - "Its singlet oxygen quantum yield produced by photosensitization is 0.38, suggesting that SiPcF is an effective 1O2 photosensitizer. " 10/01/2011 - "Our results suggest that a salt-induced photosensitization mechanism can switch from the singlet oxygen to the free-radical pathway."
3.	Phototoxic Dermatitis (Phototoxicity) 09/01/2011 - "Studies carried out on cellular uptake, photostability and singlet oxygen generation suggest that enhanced phototoxicity is primarily due to the enhanced uptake of the drug-nanoparticle complex." 09/15/2013 - "Six of the eleven 2,6-diiodo-BODIPYs investigated showed at least a sevenfold enhancement in phototoxicity (IC50 = 3.5-28 μM at 1.5 J/cm(2)) compared with the non-iodinated BODIPYs, while the others showed no cytotoxicity, while their singlet oxygen quantum yields ranged from 0.02 to 0.76. " 09/01/2011 - "The highest singlet oxygen production was achieved by the post-loaded formulation, which caused the highest phototoxicity in in vitro assays. " 05/21/2010 - "Sensitized singlet oxygen formation of 6AUd was also detected in the O(2)-saturated condition with quantum yields of 0.49 +/- 0.01 with the 248 nm excitation, indicating the high phototoxicity of 6AUd." 04/01/2010 - "Generation of singlet oxygen play a major role in phototoxicity reactions. "
4.	Pain (Aches) 01/01/2009 - "This is further confirmation that direct measurement of free radicals and singlet oxygen represents a very useful method for the biochemical evaluation of pain and nociception." 04/01/2011 - "Inflammation was reduced in 60% (n=44) of cases and patients did not report pain or discomfort when using AM. The use of singlet oxygen was shown to be safe and the results of this study indicate AM to be useful for wound cleansing, disinfection, reducing inflammation and promoting wound healing. " 01/01/2009 - "After laparotomy, which represented both somatic and visceral pain, hydroxyl radicals and singlet oxygen were increased. " 10/01/2010 - "It was proved that the biochemical markers of lipid, protein and saccharide metabolisms and free radicals as well as singlet oxygen can serve as very good indicators of the intensity of pain and nociception. " 01/01/2009 - "Results are in agreement with our previous finding regarding the increase in hydroxyl free radicals and singlet oxygen following nociceptive stimulation, in this case a combination of both somatic and visceral pain. "
5.	Breast Neoplasms (Breast Cancer) 10/04/2011 - "This increased singlet-oxygen generation shows a cytotoxic effect on BT549 breast cancer cells upon laser irradiation. " 01/03/2011 - "By using spectroscopic studies and cellular experiments, the following is demonstrated: 1) enhanced singlet-oxygen generation by means of the intraparticle heavy-atom effect on the embedded photosensitizer, 2) facilitated cell uptake due to the small nanoscopic size as well as the Pluronic surface characteristics, and thereby 3) actual enhancement of PDT efficacy for a human breast-cancer cell line (MDA-MB-231), which validates a photophysically motivated nanoformulation approach toward an advanced photosensitizing nanomedicine."

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Free Radicals
3.	Carotenoids (Carotene)
4.	pheophorbide a
5.	polyphenols
6.	phenylmethylpyrazolone
7.	Flavonoids
8.	Superoxides (Superoxide)
9.	Hydroxyl Radical
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Lasers (Laser)
3.	Semiconductor Lasers
4.	Phototherapy (Light Therapy)
5.	Drug Therapy (Chemotherapy)