Polyubiquitin

An oligomer formed from the repetitive linking of the C-terminal glycine of one UBIQUITIN molecule via an isopeptide bond to a lysine residue on a second ubiquitin molecule. It is structurally distinct from UBIQUITIN C, which is a single protein containing a tandemly arrayed ubiquitin peptide sequence.

Also Known As:

Networked: 102 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ryu, Kwon-Yul: 5 articles (10/2014 - 03/2008)
2.	Kopito, Ron R: 4 articles (09/2013 - 03/2008)
3.	Hsu, Chin-Yuan: 2 articles (01/2015 - 02/2014)
4.	Park, Chul-Woo: 2 articles (10/2014 - 01/2014)
5.	Ryu, Han-Wook: 2 articles (10/2014 - 01/2014)
6.	Iwai, Kazuhiro: 2 articles (03/2014 - 09/2011)
7.	Cohen, Philip: 2 articles (05/2013 - 02/2008)
8.	Polakis, Paul: 2 articles (02/2013 - 08/2012)
9.	Tran, Hoanh: 2 articles (02/2013 - 08/2012)
10.	Greenberg, Roger A: 2 articles (12/2012 - 03/2009)

Related Diseases

1.	Shock 12/01/1996 - "In this study, we sought to determine: 1) if these transcripts were the product of multiple genes or multiple alleles, and 2) if all polyubiquitin genes/alleles in the moth are regulated by both heat shock and the endocrine signals that regulate death. " 01/01/2015 - "The promoter of the polyubiquitin C gene (UBC) contains putative heat shock elements (HSEs) which are thought to mediate UBC induction upon stress. " 12/15/2014 - "Here we show that a full response to heat shock (activation of both HSP70 and HSP25) depends on the duration of HSF1 activation, which is itself controlled by HDAC6, a unique deacetylase known to bind monoubiquitin and polyubiquitin with high affinity. " 06/01/2003 - "Depletion of polyubiquitin conferred pleiotropic effects to mutant cells: (i) a limited increased sensitivity to mild heat shock; (ii) increased formation of colony morphology variants; and (iii) induction of hyphal and pseudohypal development. " 01/05/2000 - "Intraerythrocytic polyubiquitin expression in Plasmodium falciparum is subjected to developmental and heat-shock control."
2.	Infection 04/01/2014 - "We further show that there is no interaction between USP3 and RIG-I-like receptors (RLRs) in unstimulated or uninfected cells, but upon viral infection or ligand stimulation, USP3 binds to the caspase activation recruitment domain of RLRs and then cleaves polyubiquitin chains through cooperation of its zinc-finger Ub-binding domain and USP catalytic domains. " 07/01/2013 - "We show that levels of ubiquitinated proteins are reduced during PEDV infection and that PEDV PLP2 has deubiquitinase (DUB) activity that recognizes and processes both K-48 and K-63 linked polyubiquitin chains. " 03/01/2008 - "Western blot further confirmed the inhibition of Rho protein GDP dissociation inhibitor expression and the induction of polyubiquitin during IBDV infection. " 06/19/2014 - "Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) and activate cellular innate immunity. " 01/01/2014 - "In this study we evaluated the stability of five candidate internal reference genes: elongation factor-1-alpha (ELF1α), peptidylprolyl isomerase A (PPIA), 60S ribosomal protein L23 (RPL23), TATA-binding protein (TBP) and polyubiquitin (UBI), in relation to Israeli acute paralysis virus (IAPV) infection of Bombus terrestris. "
3.	Paralysis (Palsy) 01/01/2014 - "In this study we evaluated the stability of five candidate internal reference genes: elongation factor-1-alpha (ELF1α), peptidylprolyl isomerase A (PPIA), 60S ribosomal protein L23 (RPL23), TATA-binding protein (TBP) and polyubiquitin (UBI), in relation to Israeli acute paralysis virus (IAPV) infection of Bombus terrestris. "
4.	Dehydration (Water Stress) 02/01/2008 - "Induction of a polyubiquitin gene promoter by dehydration stresses in transformed rice cells." 02/01/2008 - "The expression of the maize polyubiquitin gene promoter UBI1 in rice cells has been used to study the involvement of ubiquitin in cell protection responses to dehydration caused by osmotic, saline or freezing stress. "
5.	Neoplasms (Cancer) 05/02/2014 - "The protein RAP80 plays a central role in the damage response by targeting BRCA1/BRCA2 tumor suppressors to DNA damage foci through multivalent binding of Lys-63-linked polyubiquitin chains. " 02/01/2007 - "The breast and ovarian tumor suppressor BRCA1 catalyzes untraditional polyubiquitin chains that could be a signal for processes other than proteolysis. " 08/06/2004 - "The BRCA1 tumor suppressor and the BARD1 protein form a stable heterodimeric complex that can catalyze the formation of polyubiquitin chains. " 11/15/2009 - "In carcinogenesis, the K63 polyubiquitin pathway is possibly critical for inflammation-driven tumor promotion. " 03/17/2006 - "Self-assembly has profound consequences for the processive formation of polyubiquitin (poly-Ub) chains in ubiquitination reactions directed by the breast and ovarian cancer tumor susceptibility protein BRCA1."

Related Drugs and Biologics

1.	Ubiquitin
2.	Lysine (L-Lysine)
3.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
4.	Ribosomal Proteins (Ribosomal Protein)
5.	TNF Receptor-Associated Factor 6 (TRAF6)
6.	TATA-Box Binding Protein (TATA-Binding Protein)
7.	Peptidylprolyl Isomerase (Prolyl Isomerase)
8.	tributyl phosphate (TBP)
9.	Messenger RNA (mRNA)
10.	Proteasome Endopeptidase Complex (Proteasome)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Denervation