WT1 Proteins

Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.

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Networked: 255 relevant articles (4 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sugiyama, Haruo: 38 articles (12/2015 - 05/2002)
2.	Oji, Yusuke: 33 articles (12/2015 - 05/2002)
3.	Oka, Yoshihiro: 31 articles (12/2015 - 05/2002)
4.	Tsuboi, Akihiro: 27 articles (07/2015 - 05/2002)
5.	Hosen, Naoki: 20 articles (12/2015 - 05/2002)
6.	Kawase, Ichiro: 16 articles (02/2014 - 07/2002)
7.	Nakajima, Hiroko: 15 articles (07/2015 - 12/2002)
8.	Nishida, Sumiyuki: 14 articles (07/2015 - 12/2002)
9.	Fujiki, Fumihiro: 12 articles (07/2015 - 07/2004)
10.	Kawakami, Manabu: 12 articles (04/2007 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2010 - "The discrepancy in WT1 expression between these methods suggested that immunohistochemical detection of WT1 peptide may be advantageous for predicting the efficacy of WT1 vaccine compared to RT-PCR, and the highly sensitive WT1 antibody, WT1-R, may be useful to detect WT1 protein in tumors." 05/01/2015 - "Potential diagnostic pitfalls from unexpected WT1 protein expression in some tumors will be discussed in order to avoid diagnostic errors, especially when dealing with small biopsies. " 05/01/2015 - "This review focuses on the immunohistochemical profile of WT1 protein in the most common malignant tumors of children and adolescents. " 02/01/2013 - "WT1 protein was detected on actively proliferating cancer nests and even on elongated epithelial ridge where new droplet-cancer-nests were being formed and starting infiltration toward subepithelial layer. " 02/01/2013 - "Immunohistochemical analysis of tissue sections showed overexpression of WT1 protein in two patients, concentrated mainly in the cytoplasm of the outer one to three cell layers of the cancer nests. "
2.	Wilms Tumor (Wilm's Tumor) 12/01/2005 - "Our studies show that the gut is initially devoid of a mesothelium but that serosal mesothelial cells expressing the Wilm's tumor protein (Wt1) move to and over the gut. " 11/01/1996 - "Study of genotype/phenotype relationships involving the Wilms' tumor (WT) gene, WT1, in WT patients has provided insights into the function of the WT1 protein, a transcriptional regulator, and has suggested possible mutational mechanisms important in the etiology of WT. For example, the identification of deletion/insertion mutations in the first exon implicates a deletion hotspot consensus sequence in the etiology of these mutations. " 05/01/2015 - "Wilms' tumor 1 (WT1) protein expression in human developing tissues." 05/01/2015 - "Oncofetal expression of Wilms' tumor 1 (WT1) protein in human fetal, adult and neoplastic skeletal muscle tissues." 08/29/2014 - "We report here that the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2011 - "Finally, we found a significant inverse correlation between miR-15a or miR-16-1 expression and WT1 protein levels in primary acute myeloid leukemia (AML) blasts and normal controls. " 08/15/2000 - "Western blot analyses showed WT1-specific antibodies directed against the N-terminus portion of the WT1 protein in the sera of 3 of 18 patients with acute myeloid leukemia (AML). " 05/01/2008 - "By contrast, 40 primary samples of acute lymphoblastic leukemia (ALL; B-ALL, n = 15 and T-ALL, n = 10) and acute myeloid leukemia (n = 15) expressed low levels of WT1 protein. " 09/15/2002 - "CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia." 09/15/2002 - "Wilms tumor gene product WT1 and proteinase 3 are overexpressed antigens in acute myeloid leukemia (AML), against which cytotoxic T lymphocytes can be elicited in vitro and in murine models. "
4.	Glioma (Gliomas) 08/01/2010 - "We examined 50 low-grade and high-grade gliomas using tissue microarray and immunohistochemical methods to identify WT1 protein, P53, Ki-67, GFAP, NFP, EGFR, nestin, and Neu-N expression. " 06/01/2007 - "In T98G and LN-18 glioma cells, which possess p53 mutations, WT1 siRNA decreased WT1 protein to almost undetectable levels by 96-h post-transfection. " 04/01/2012 - "Immunotherapy targeting the Wilms tumor 1 (WT1) gene product is a promising treatment modality for patients with malignant gliomas, and there have been reports of encouraging results. " 04/01/2012 - "The Wilms tumor 1 (WT1) protein-a developmentally regulated transcription factor-is aberrantly expressed in gliomas and promotes their malignant phenotype. " 11/01/2010 - "We retrospectively studied WT1 protein expression by immunohistochemistry (IHC) in 100 formalin-fixed, paraffin-embedded brain tissue samples consisting of 3 normal control tissues, 44 cases of reactive gliosis, 49 gliomas and 4 lesions suspicious for glioma. "
5.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 07/01/2015 - "Individuals with WT1-positive acute myeloid leukemia (AML) in first (CR1) or second (CR2) remission or with higher-risk myelodysplastic syndrome (MDS) following at least 1 prior line of therapy were vaccinated with a mixture of peptides derived from the WT1 protein, with sargramostim injections before vaccination to amplify immunogenicity. " 07/01/2003 - "The Wilms tumor gene, WT1, is overexpressed not only in leukemias and myelodysplastic syndrome (MDS) but also in various types of solid tumors, including lung and breast cancer, and the WT1 protein is a tumor antigen for these malignancies. " 08/01/2002 - "Furthermore, WT1 immunoglobulin M (IgM) and IgG antibodies are detected in patients with hematopoietic malignancies such as acute myeloid leukemia, chronic myeloid leukemia, and myelodysplastic syndromes, indicating that WT1 protein overexpressed by leukemia cells is indeed immunogenic. "

Related Drugs and Biologics

1.	Peptides
2.	sargramostim (Leukine)
3.	Transcription Factors (Transcription Factor)
4.	Antibodies
5.	Messenger RNA (mRNA)
6.	Vaccines
7.	Proteins (Proteins, Gene)
8.	Epitopes
9.	nephrin
10.	Keratin-20 (Cytokeratin 20)

Related Therapies and Procedures

1.	Immunotherapy
2.	Injections
3.	Therapeutics
4.	Intraperitoneal Injections