Halorhodopsins (Halorhodopsin)

Light driven chloride ion pumps that are ubiquitously found in halophilic archaea (HALOBACTERIALES).

Also Known As:

Halorhodopsin; 9-cis-Halorhodopsin; Halorhodopsin Chromoprotein; 9 cis Halorhodopsin

Networked: 16 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Deisseroth, Karl: 2 articles (11/2012 - 07/2010)
2.	Jerwick, Jason: 1 article (01/2020)
3.	Li, Airong: 1 article (01/2020)
4.	Li, Zilong: 1 article (01/2020)
5.	Men, Jing: 1 article (01/2020)
6.	Tanzi, Rudolph E: 1 article (01/2020)
7.	Zhou, Chao: 1 article (01/2020)
8.	Greenwood-Van Meerveld, Beverley: 1 article (01/2018)
9.	Herr, Hugh M: 1 article (01/2018)
10.	Johnson, Anthony C: 1 article (01/2018)

Related Diseases

1.	Retinal Degeneration 07/22/2009 - "In this study, we report that the expression of halorhodopsin (HaloR), a light-driven chloride pump, can effectively restore OFF responses in inner retinal neurons of mice with retinal degeneration. " 01/01/2014 - "Even more exciting is the potential for therapeutic use of the Arr4 promoter with an AAV-halorhodopsin that was shown to be effective in using the remaining cones in retinal degeneration mouse models to drive inner retinal circuitry for motion detection and light/dark discrimination. "
2.	Photophobia (Light Sensitivity) 07/23/2010 - "Here, we show that expression of archaebacterial halorhodopsin in light-insensitive cones can substitute for the native phototransduction cascade and restore light sensitivity in mouse models of retinitis pigmentosa. " 10/01/2015 - "Optogenetic gene therapies are in development, but, to date, have suffered from the low light sensitivity of microbial opsins, such as channelrhodopsin and halorhodopsin, and azobenzene-based photoswitches. "
3.	Hypersensitivity (Allergy) 01/01/2018 - "Photoactivation of amygdala fibers in the stria terminalis with channelrhodopsin induced colonic hypersensitivity, whereas inhibition of the same fibers with halorhodopsin did not alter colonic sensitivity." 10/01/2016 - "In addition, unilateral optogenetic silencing of ACC excitatory neurons with halorhodopsin significantly decreased mechanical hypersensitivity in tumor-bearing mice (n = 4 to 9), and conversely, optogenetic activation of these neurons with channelrhodopsin-2 was sufficient to provoke mechanical hypersensitivity in sham-operated mice (n = 5 to 9). "
4.	Ganglion Cysts (Ganglion) 02/24/2011 - "We have introduced the optical neuromodulators channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR) differentially into the soma and dendrites of ganglion cells to recreate antagonistic center-surround receptive field interactions. "
5.	Hypokinesia (Bradykinesia) 01/01/2016 - "Dorsal striatal photoinhibition of ChIs in lesioned ChAT(cre/cre) mice expressing halorhodopsin in ChIs reduces akinesia, bradykinesia, and sensorimotor neglect. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Retinaldehyde (Retinal)
3.	Chlorides
4.	Channelrhodopsins
5.	Opsins
6.	Neurotransmitter Agents (Neurotransmitter)
7.	Proton Pumps (Proton Pump)
8.	Ion Channels (Ion Channel)
9.	Carisoprodol (Soma)
10.	azobenzene

Related Therapies and Procedures

1.	Therapeutics