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Ventricular Myosins

Subscribe to New Research on Ventricular Myosins

Isoforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in the genes encoding ventricular myosins result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

Also Known As:

Cardiac alpha-Myosin; Cardiac beta-Myosin; Myosin V1; Myosin V2; Myosin V3; Myosin, Ventricular; Ventricular Cardiac alpha-Myosin; Ventricular Cardiac beta-Myosin; Ventricular Isomyosins; Ventricular Myosin; Ventricular alpha, beta- Myosin; Ventricular alpha-Myosin; Ventricular beta-Myosin; alpha-Myosin; beta-Myosin; Cardiac alpha Myosin; Cardiac alpha-Myosin, Ventricular; Cardiac beta Myosin; Cardiac beta-Myosin, Ventricular; Isomyosins, Ventricular; Myosins, Ventricular; Ventricular Cardiac alpha Myosin; Ventricular Cardiac beta Myosin; Ventricular alpha Myosin; Ventricular alpha, beta Myosin; Ventricular beta Myosin; alpha Myosin; alpha-Myosin, Cardiac; alpha-Myosin, Ventricular; alpha-Myosin, Ventricular Cardiac; beta Myosin; beta-Myosin, Cardiac; beta-Myosin, Ventricular; beta-Myosin, Ventricular Cardiac

Networked: 461 relevant articles (4 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Szczesna-Cordary, Danuta: 9 articles (01/2014 - 08/2005)
2.	Leinwand, Leslie A: 7 articles (07/2010 - 06/2002)
3.	Eriksson, Urs: 6 articles (10/2009 - 07/2002)
4.	Kazmierczak, Katarzyna: 5 articles (01/2014 - 03/2009)
5.	Robbins, Jeffrey: 5 articles (02/2010 - 06/2002)
6.	Ackerman, Michael J: 5 articles (07/2009 - 06/2002)
7.	Muthu, Priya: 4 articles (08/2013 - 05/2010)
8.	Borejdo, J: 4 articles (09/2011 - 02/2009)
9.	Perrot, Andreas: 4 articles (01/2011 - 11/2002)
10.	Kraft, Theresia: 4 articles (01/2010 - 03/2002)

Related Diseases

1.	Hypertrophy 08/01/1997 - "At matched LA pressure, LA ejection (10.2 +/- 3.0 vs. 17.4 +/- 5.5%), reservoir volume fractions (19 +/- 8 vs. 35 +/- 11%), and heart rate-corrected mean normalized systolic ejection rate (1.25 +/- 0.33 vs. 1.60 +/- 0.44 EF/s) were significantly less, and the volume-normalized diastolic stiffness constant (4.9 +/- 0.8 vs. 3.2 +/- 1.1) was significantly greater, in regression versus control dogs; these changes were associated with incomplete regression of LA hypertrophy and a persistent 77.4% increase in beta-myosin heavy chain (beta-MHC) in the LA body. " 02/15/2012 - "The present study focuses on the A13T mutation in the human ventricular myosin RLC (regulatory light chain) that is associated with a rare FHC variant defined by mid-ventricular obstruction and septal hypertrophy. " 01/01/2015 - "Four ND with highly upregulated and 5 D with highly downregulated miR-133a were analyzed for autophagy markers (Beclin1, LC3B, ATG3) and their upstream regulators (mTOR and AMPK), and hypertrophy marker (beta-myosin heavy chain) by RT-qPCR, Western blotting and immunofluorescence. " 08/01/2009 - "Finally, cardiomyocyte hypertrophy was evaluated by, the expression of beta-myosin heavy chain, alpha-skeletal actin, cell size, and amino acid incorporation. " 07/01/2009 - "Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain."
2.	Cardiomegaly (Heart Hypertrophy) 07/01/2008 - "The SHR-MCT group displayed improved cardiac dysfunction [as assessed by left ventricular (LV) end-diastolic pressure and the positive and negative first derivatives of LV pressure/P value], a shift in the beta-myosin heavy chain (MHC)-to-alpha-MHC ratio, and cardiac hypertrophy compared with the SHR-LCT group without an effect on blood pressure. " 06/22/2001 - "In the present study, we examined the role of gp130 in pressure overload-induced cardiac hypertrophy using transgenic (TG) mice, which express a dominant negative mutant of gp130 in the heart under the control of alpha myosin heavy chain promoter. " 01/01/2014 - "In this report we aimed to explore the molecular pathways leading to two different phenotypes of cardiac hypertrophy in transgenic mice carrying mutations in the human ventricular myosin essential light chain (ELC). " 03/19/2010 - "In the absence of Ang II, adult Xirp2 hypomorphic mice displayed cardiac hypertrophy and increased beta myosin heavy chain expression. " 07/01/2009 - "Cardiac hypertrophy is associated with a reduction in the contractile response to beta-adrenergic stimulation, and with re-expression of foetal genes such as beta-myosin heavy chain (MHC). "
3.	Fibrosis (Cirrhosis) 05/01/2010 - "Recently, microRNA-208 (miR-208) encoded by the alpha-myosin heavy chain (MHC) gene, has been shown to be involved in pathological cardiac growth, fibrosis, and up-regulation of beta-MHC expression. " 11/07/2006 - "Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo." 07/23/1999 - "TGII overexpression resulted in a remodeling of the heart with mild hypertrophy, elevated expression of beta-myosin heavy chain and alpha-skeletal actin genes, and diffuse interstitial fibrosis. " 04/27/2007 - "The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of alpha-myosin heavy chain (alphaMHC) and up-regulation of betaMHC, the primary contractile proteins of the heart. " 08/01/1999 - "In striking contrast to truncation mice, however, the R92Q hearts demonstrate significant induction of atrial natriuretic factor and beta-myosin heavy chain transcripts, interstitial fibrosis, and mitochondrial pathology. "
4.	Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy) 08/01/2006 - "The aim of this study was to identify mutations in the cardiac heavy-chain beta-myosin gene (MYH7b) in a group of Spanish patients with hypertrophic cardiomyopathy. " 06/01/1997 - "This study investigates (1) the in vitro velocities of translocation of fluorescently-labelled actin by beta-myosin purified from soleus muscle of 30 hypertrophic cardiomyopathy patients with seven distinct beta-myosin heavy chain gene mutations: Thr124Ile, Tyr162Cys, Gly256Glu, Arg403Gln, Val606Met, Arg870His, and Leu908Val mutations; and (2) motility activity of beta-myosin purified from cardiac and soleus muscle biopsies in the same patients. " 09/01/2014 - "A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy." 05/01/2014 - "Beta-myosin heavy-chain mutations R403QLW, V606M, K615N and R663H in patients with hypertrophic cardiomyopathy." 08/01/2011 - "To detect the gene mutations of beta-myosin heavy chain gene (MYH7) in Chinese pedigrees with hypertrophic cardiomyopathy (HCM), and to analyze the correlation between the genotype and phenotype. "
5.	Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic) 02/17/2009 - "Clinical studies have revealed that the D166V mutation in the ventricular myosin regulatory light chain (RLC) can cause a malignant phenotype of familial hypertrophic cardiomyopathy (FHC). " 01/01/2012 - "D166V point mutation in the ventricular myosin regulatory light chain (RLC) is one of the causes of familial hypertrophic cardiomyopathy (FHC). " 06/29/2010 - "A single-point mutation in the gene encoding the ventricular myosin regulatory light chain (RLC) is sufficient to cause familial hypertrophic cardiomyopathy (FHC). " 05/01/2010 - "One of the sarcomeric mutations associated with a malignant phenotype of familial hypertrophic cardiomyopathy (FHC) is the D166V point mutation in the ventricular myosin regulatory light chain (RLC) encoded by the MYL2 gene. " 09/01/2009 - "A novel mutation of the beta myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy."

Related Drugs and Biologics

1.	glycogen synthase kinase 3 beta
2.	Dobutamine
3.	Simvastatin (Zocor)
4.	Tropomyosin
5.	Atrial Natriuretic Factor (ANF)
6.	Troponin T (T, Troponin)
7.	Ventricular Myosins
8.	Actins (F Actin)
9.	Proteins (Proteins, Gene)
10.	Cardiac Myosins

Related Therapies and Procedures

1.	Caloric Restriction
2.	Ligation
3.	Drug Therapy (Chemotherapy)
4.	Transplants (Transplant)
5.	Cell Transplantation