Myosin Type V

A subclass of myosin involved in organelle transport and membrane targeting. It is abundantly found in nervous tissue and neurosecretory cells. The heavy chains of myosin V contain unusually long neck domains that are believed to aid in translocating molecules over large distances.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yengo, Christopher M: 3 articles (01/2021 - 11/2015)
2.	Sellers, James R: 3 articles (09/2005 - 01/2002)
3.	Wang, Fei: 3 articles (09/2005 - 01/2002)
4.	Tang, Wanjian: 2 articles (01/2021 - 12/2020)
5.	Thomas, David D: 2 articles (12/2020 - 11/2015)
6.	Veigel, Claudia: 2 articles (09/2005 - 01/2002)
7.	Desetty, Rohini: 1 article (01/2021)
8.	Ge, Jinghua: 1 article (01/2021)
9.	Unrath, William C: 1 article (01/2021)
10.	Cirilo, Joseph A: 1 article (12/2020)

Related Diseases

1.	Infections 01/01/2018 - "Here, in a knock-out experiment, we characterized the role of VdMyo5, a member of the Myosin V family, before and during infection of cotton and Arabidopsis thaliana. " 10/01/2012 - "In this study, we report that the addition of nutrients (glucose, yeastolate ultrafiltrate, and lactalbumin hydrolysate) and small fraction of fresh medium at time of infection restores the expression level of actin and myosin V-HMM at late exponential phase (11.3 × 10(6) cells/ml) to that at early exponential phase (1.0 × 10(6) cells/ml). " 12/07/2017 - "To assess the latter, we evaluated the role of myosin light chain kinase (MLCK) and two myosin V isoforms (Va and Vb) in RV-B14 infection. "
2.	Melanoma (Melanoma, Malignant) 10/01/1997 - "The present studies were undertaken to gain insight into the subcellular distribution of myosin-V in the melanoma cell line B16-F10, which is wild-type for the dilute gene. " 04/01/1998 - "In contrast, S91 mouse melanoma cells exhibit aberrant melanosomal trafficking, in accordance with the known defect in myosin-V mediated melanosomal transport. "
3.	Body Weight (Weight, Body) 01/01/2013 - "There was no observed a neuroprotective effect of AA (1 mL/g body weight) on the neuronal population myenteric myosin V immunoreactive." 12/01/2008 - "The effect of vitamin E (1 g/kg body weight) supplementation on myosin-V and neuronal nitric oxide synthase (nNOS) immunoreactive myenteric neurons from the ileum of diabetic rats was investigated in the present study. "
4.	Mucormycosis 01/01/2022 - "Our previous study on Mucor circinelloides, a common pathogen of mucormycosis, showed that the Myo5 protein (ID 51513) belonging to the myosin type V family had a critical impact on the growth and virulence of this fungus. "
5.	Stroke (Strokes) 06/01/2005 - "At superstall forces of 5 pN, we observe continuous backward stepping of myosin-V, indicating that a force-driven reversal of the power stroke is possible." 12/23/2002 - "The prepower stroke conformation of myosin V." 10/29/2002 - "Our model is that one head of the two-headed myosin V tightly binds to actin and swings its long lever arm through a large angle, providing a stroke. " 01/01/2002 - "The working stroke produced by a myosin V head is approximately 25 nm, consisting of two separate mechanical phases (20 + 5 nm). " 11/12/2001 - "The large M5(HMM) working stroke is consistent with the myosin V neck acting as a mechanical lever. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)
3.	Vitamin E
4.	Lactalbumin (alpha-Lactalbumin)
5.	Glucose (Dextrose)
6.	Myosins (Myosin)
7.	Myosin Type II
8.	Myosin Type I (Myosin IA)
9.	Phosphates (Orthophosphate)
10.	Adenosine Triphosphatases (ATPase)