alpha-Tocopherol

A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.

Also Known As:

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol; R,R,R-alpha-Tocopherol; Tocopherol Acetate; Tocopherol Succinate; Tocopheryl Acetate; Vitamin E Succinate; alpha-Tocopherol Acetate; alpha-Tocopherol Hemisuccinate; alpha-Tocopherol Succinate; alpha-Tocopheryl Calcium Succinate; d-alpha Tocopherol; d-alpha-Tocopheryl Acetate; Acetate, Tocopherol; Tocopherol, d-alpha; alpha Tocopherol; alpha Tocopherol Acetate; alpha Tocopherol Hemisuccinate; alpha Tocopherol Succinate; alpha Tocopheryl Calcium Succinate; d alpha Tocopherol; d alpha Tocopheryl Acetate

Networked: 2941 relevant articles (216 outcomes, 724 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Vitamin E: 8680
        Tocopherols: 1861
        alpha-Tocopherol: 2941
        AS03 adjuvant: 23
        alpha-tocopherol phosphate: 15
        karinat: 6
        1-thio-alpha-tocopherol: 1
        alpha-tocopherol 5-n-butyl-2-pyridinecarboxylate: 1
        alpha-tocopheryl malonate: 1
        alpha-tocopheryl oxalate: 1
        BJ-1301: 1
        RRR-alpha-tocopheryloxybutyl sulfonic acid: 1
        2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chlorochroman
        8a-hydroperoxy-tocopherone
        alpha-di-tocopheryl phosphate
        alpha-tocopherol hexaethylene glycol succinate
        alpha-tocopherol quinol
        alpha-tocopherol succinyl dodecaethylene glycol
        deoxy-alpha-tocopherolquinol
        MitoVE11S
        polyoxyethanyl-alpha-tocopheryl sebacate
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Vitamin E: 8680
        Tocopherols: 1861
        alpha-Tocopherol: 2941
        AS03 adjuvant: 23
        alpha-tocopherol phosphate: 15
        karinat: 6
        1-thio-alpha-tocopherol: 1
        alpha-tocopherol 5-n-butyl-2-pyridinecarboxylate: 1
        alpha-tocopheryl malonate: 1
        alpha-tocopheryl oxalate: 1
        BJ-1301: 1
        RRR-alpha-tocopheryloxybutyl sulfonic acid: 1
        2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chlorochroman
        8a-hydroperoxy-tocopherone
        alpha-di-tocopheryl phosphate
        alpha-tocopherol hexaethylene glycol succinate
        alpha-tocopherol quinol
        alpha-tocopherol succinyl dodecaethylene glycol
        deoxy-alpha-tocopherolquinol
        MitoVE11S
        polyoxyethanyl-alpha-tocopheryl sebacate

Experts

1.	Albanes, Demetrius: 168 articles (04/2022 - 01/2002)
2.	Virtamo, Jarmo: 118 articles (01/2019 - 01/2002)
3.	Weinstein, Stephanie J: 98 articles (02/2022 - 03/2005)
4.	Taylor, Philip R: 58 articles (01/2019 - 01/2002)
5.	Männistö, Satu: 43 articles (04/2022 - 12/2003)
6.	Albanes, D: 33 articles (01/2018 - 01/2000)
7.	Virtamo, J: 32 articles (09/2013 - 01/2000)
8.	Pietinen, Pirjo: 29 articles (06/2007 - 04/2002)
9.	Mondul, Alison M: 27 articles (01/2020 - 03/2004)
10.	Stolzenberg-Solomon, Rachael Z: 26 articles (01/2017 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Pharmacogenetic analysis of COMT and cancer prevention in two large randomized trials revealed statistically significant COMT by alpha-tocopherol interaction, such that alpha-tocopherol was beneficial among rs4680 met-allele (28.0%), but not val-allele (22.8%) homozygotes. " 01/01/2019 - "Here we determined if COMT exerted pharmacogenetic effects on cancer prevention in two randomized trials of alpha-tocopherol supplementation. " 01/01/2019 - "COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials." 04/01/2010 - "Studies on alpha-tocopherol in animal models also have not demonstrated robust cancer prevention effects. " 07/01/2006 - "In the ATBC Cancer Prevention Study Group, no statistically significant effect of treatment was seen for any cancer individually, and our pooled relative risk (regardless of tumor type) for alpha-tocopherol alone was 0.91 (95% confidence interval [CI]: 0.74, 1.12). "
2.	Ischemia 09/01/2006 - "Rabbit filtration renal function 1 hour after circulation recovery improved insignificantly, 24 hours after the recovery no difference with the control was registered, while secretory and reabsorption functions of the renal tubules under conditions of pretreatment with alpha-tocopherol significantly improved both in rabbits and rats both 1 hour and 24 hours after ischemia. " 01/01/1996 - "However, 4 weeks of dietary enrichment of rats with alpha-tocopherol (1000 IU/kg) was effective in suppressing these ischemia reperfusion-induced changes. " 01/01/1998 - "The aim of our study was to analyse the protective effects of different alpha-tocopherol analogues 1) against fibrillations induced by an ischemia-reperfusion sequence, and 2) to further investigate in vitro the radical scavenging properties of these analogues by two sensitive methods. " 12/01/2008 - "For this study, ob/ob mice received 50 IU/d vitamin E succinate in supplemented vs control chow for 7 days, and were subjected to 15 minutes of total hepatic ischemia and 24 hours of reperfusion. " 12/01/2005 - "This study evaluated the effect of alpha-tocopherol (alpha-TC), ischemic preconditioning (IPC) or a combination on the extent of mitochondrial injury caused by hepatic ischemia/reperfusion (I/R). "
3.	Inflammation (Inflammations) 11/01/1997 - "A shift toward sources of alpha-tocopherol other than synthesized milk fat occurred during acute inflammation in the mammary gland." 12/01/2002 - "Oxidative stress, inflammation, and diabetic vasculopathies: the role of alpha tocopherol therapy." 11/01/2021 - "Alpha-tocopherol was found to reduce inflammation and pancreatic damage in acute pancreatitis and was more effective in high doses." 07/01/2006 - "Alpha-tocopherol when administered in the chosen study design in an animal model of asthma had no major effect on airway inflammation. " 03/01/2010 - "The high dose of selenomethionine reduced the severity of epithelial dysplasia in the lateral prostate that was not associated with inflammation, and alpha-tocopherol reduced in a dose-related fashion the incidence of marked inflammation and marked epithelial dysplasia in the lateral prostate, regardless of whether these lesions were associated with inflammation. "
4.	Fibrosis (Cirrhosis) 08/01/2010 - "Hundred and five HCV patients with a Metavir fibrosis score > or = 2 were randomized to receive peginterferon alpha-2a 180 microg/week (PEG) (n=55) or alpha-tocopherol (TOCO) 1000 mg/day (n=50) for 96 weeks. " 08/01/2010 - "The aim was to evaluate the efficiency of 2 years of treatment with peginterferon alpha-2a vs alpha-tocopherol in these patients by histology, morphometry and blood markers of fibrosis. " 09/01/2008 - "Treatment with PTX and alpha-tocopherol may have beneficial effects on radiation-induced myocardial fibrosis and left ventricular function, both when started before irradiation and when started later during the process of RIHD." 04/01/1999 - "Experimental cirrhosis of the liver and cytoprotective effects of alpha tocopherol." 06/01/1993 - "By contrast, levels of alpha-tocopherol were decreased significantly only in patients with cirrhosis, who displayed a threefold reduction. "
5.	Reperfusion Injury 12/01/2005 - "Protective effects of alpha-tocopherol and ischemic preconditioning on hepatic reperfusion injury." 09/01/2013 - "Alpha-tocopherol ameliorates oxidative renal insult associated with spinal cord reperfusion injury." 07/07/2010 - "A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats." 03/01/2010 - "In this report, the effect of Vitamin E succinate (VES) on ischemia/reperfusion injury and NF-κB expression was studied in a rat skeletal muscle model during reperfusion following a 4-h ischemic period. " 03/01/2010 - "The effect of vitamin e succinate on ischemia reperfusion injury."

Related Drugs and Biologics

1.	Vitamin E
2.	Antioxidants
3.	Ascorbic Acid (Vitamin C)
4.	alpha-Tocopherol
5.	beta Carotene (Betacarotene)
6.	Vitamin A (Retinol)
7.	Selenium
8.	gamma-Tocopherol
9.	Lipids
10.	Free Radicals

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Chemoprevention
4.	Intraperitoneal Injections
5.	Ligation