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HMGB1 Protein (HMG1)

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A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.

Also Known As:

HMG1; Amphoterin; Box Protein 1, High Mobility Group; FM1 Gene Product; HMG 1 Protein; HMG-1 Protein; HMGB1; Heparin-Binding Protein p30; Heparin Binding Protein p30; p30, Heparin-Binding Protein

Networked: 1897 relevant articles (104 outcomes, 367 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Tracey, Kevin J: 77 articles (12/2015 - 01/2002)
2.	Wang, Haichao: 66 articles (01/2015 - 01/2002)
3.	Yang, Huan: 56 articles (12/2015 - 01/2002)
4.	Bianchi, Marco E: 41 articles (03/2015 - 07/2002)
5.	Maruyama, Ikuro: 36 articles (04/2015 - 12/2004)
6.	Lotze, Michael T: 35 articles (12/2015 - 12/2003)
7.	Tang, Daolin: 34 articles (07/2015 - 05/2005)
8.	Yu, Yan: 34 articles (01/2015 - 03/2003)
9.	Billiar, Timothy R: 31 articles (12/2015 - 04/2005)
10.	Andersson, Ulf: 29 articles (01/2015 - 12/2002)

Related Diseases

1.	Sepsis (Septicemia) 12/01/2013 - "These findings indicate that exposure to HMGB1 enhances splenocyte responses to secondary inflammatory challenges, a priming effect dependent on TLR4, and that anti-HMGB1 monoclonal antibody may be beneficial in sepsis survivors. " 04/01/2012 - "It is concluded that EEPV induces HO-1 expression through PI3K/Nrf2 signal pathways, which may be beneficial for the treatment of sepsis due to a reduction of HMGB1 release." 02/15/2009 - "Our results suggest that HMGB1 release in sepsis is dependent on the IFN-beta signaling axis; thus, therapeutic agents that selectively inhibit IFN-beta signaling could be beneficial in the treatment of sepsis." 01/01/2012 - "MBC extract is protective against lethal sepsis possibly by stimulating autophagic HMGB1 degradation." 10/01/2007 - "The improved survival associated with BLP tolerance could thus be explained by a reduction in HMGB1, were the latter associated with lethality in BLP-related sepsis. "
2.	Inflammation 01/01/2015 - "Natural and synthetic SA derivatives with greater potency for inhibition of HMGB1 were identified, providing proof-of-concept that new molecules with high efficacy against sterile inflammation are attainable. " 11/01/2014 - "(i) The frequency of sterile intra-amniotic inflammation was significantly greater than that of microbial-associated intra-amniotic inflammation [26% (35/135) versus 11% (15/135); (P = 0.005)], (ii) patients with sterile intra-amniotic inflammation delivered at comparable gestational ages had similar rates of acute placental inflammation and adverse neonatal outcomes as patients with microbial-associated intra-amniotic inflammation, and (iii) patients with sterile intra-amniotic inflammation and high AF concentrations of HMGB1 (≥8.55 ng/mL) delivered earlier than those with low AF concentrations of HMGB1 (P = 0.02). " 07/01/2011 - "Relationship between HMGB1 and tissue protective effects of HSP72 in a LPS-induced systemic inflammation model." 03/01/2011 - "In addition, 1-μg HMGB1 decreased myocardial inflammation but did not result in subsequent improvement in functional recovery. " 01/01/2008 - "Our current understanding of HMGB1 has promoted the development of targeting therapies that have improved outcomes in animal models of inflammation. "
3.	Endotoxemia 02/01/2006 - "sinensis significantly attenuated systemic HMGB1 accumulation in vivo, and conferred a dose-dependent protection against lethal endotoxemia. " 08/01/2009 - "This study aims to test the hypothesis that in response to LPS stimulation, hepatic Kupffer cells and extrahepatic macrophages release a large amount of the inflammatory cytokine high-mobility group box 1 (HMGB1) into the bile and that bile containing HMGB1 contributes to gut barrier dysfunction in experimental endotoxemia. " 08/01/2009 - "In the present study, we wanted to determine whether tissue and circulating levels of HMGB1 are increased further in the absence of HO-1 during endotoxemia, and whether this increase may contribute to the pathobiology of endotoxemia. " 01/01/2013 - "However, the effect of GL on HMGB1 expression in endotoxemia as well as its underlying molecular mechanism remained unclear. " 09/01/2011 - "Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model."
4.	Neoplasms (Cancer) 04/01/2013 - "The direct tumor response to bacillus Calmette-Guérin, culminating in HMGB1 release, may be an important contributor to the clinical efficacy of bacillus Calmette-Guérin." 10/01/2013 - "Application of HMGB1 inhibitors when restoring p53 in cancer therapy might protect against pro-tumorigenic effects while leaving p53-mediated clearance of malignant cells intact." 04/01/2013 - "An orthotopic tumor model was used to compare the in vivo antitumor efficacy of bacillus Calmette-Guérin in the parental cell line (24 control and 24 bacillus Calmette-Guérin treated) vs the HMGB1 knockdown line (23 control and 21 treated). " 05/01/2015 - "In the present study, we explored the mechanisms whereby HMGB1 regulates tumor cell autophagy during nutrient depletion (the cells were cultured in Hank's balanced salt solution, HBSS). " 01/01/2015 - "The literature search identified a total of 12 relevant studies on HMGB1 expression for inclusion in the meta-analysis: seven in ovarian tumor tissue, four in ovarian tumor patient serum, and one in both tissue and serum. "
5.	Lung Injury 07/01/2014 - "The resulting attenuation in lung injury and improvement in bacterial clearance were associated with decreased levels of airway HMGB1. " 01/01/2015 - "In this study, we explored whether blocking HMGB1 has a preventive effect on the early radiation-induced lung injury and investigate the mechanism. " 01/01/2014 - "In this study, we investigated the role of the proinflammatory cytokine high mobility group box protein 1 (HMGB1) in hyperoxic inflammatory lung injury, using an adult mouse model. " 01/01/2007 - "The purpose of this study was to evaluate the effect of NM on HMGB1 in lipopolysaccharide (LPS)-induced lung injury in rats. " 06/01/2015 - "However, therapy with H2 increased the survival rate and alleviated the severity of lung injury, reduced the HMGB1 level, and increased the HO-1 and Nrf2 levels in septic mice. "

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