HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

HMGB1 Protein (HMG1)

A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.
Also Known As:
HMG1; Amphoterin; Box Protein 1, High Mobility Group; FM1 Gene Product; HMG 1 Protein; HMG-1 Protein; HMGB1; Heparin-Binding Protein p30; Heparin Binding Protein p30; p30, Heparin-Binding Protein
Networked: 5314 relevant articles (339 outcomes, 1041 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Tracey, Kevin J: 98 articles (01/2022 - 01/2002)
2. Wang, Haichao: 86 articles (01/2021 - 01/2002)
3. Yang, Huan: 75 articles (01/2022 - 01/2002)
4. Nishibori, Masahiro: 67 articles (04/2022 - 12/2007)
5. Andersson, Ulf: 54 articles (01/2022 - 12/2002)
6. Bianchi, Marco E: 54 articles (10/2021 - 07/2002)
7. Billiar, Timothy R: 52 articles (01/2021 - 04/2005)
8. Tang, Daolin: 51 articles (01/2022 - 05/2005)
9. Maruyama, Ikuro: 44 articles (01/2021 - 12/2004)
10. Lotze, Michael T: 44 articles (12/2020 - 12/2003)

Related Diseases

1. Inflammation (Inflammations)
01/01/2020 - "Our results suggested that the pretreatment with SSa provided significant protection against cerebral I/R injury in rats via its anti-inflammation property by inhibiting the nucleus HMGB1 release."
01/01/2018 - "Compared with HMGB1 Flox mice and wild-type (WT) mice, HMGB1 PF4 mice showed significantly higher bacterial loads in the peritoneum and blood, an exaggerated systemic inflammation response, and significantly greater mortality after CLP. "
01/01/2016 - "In conclusion all these results suggested that pretreatment with EEFPO provided significant protection against cerebral I/R injury in rats might by virtue of its anti-inflammation property through inhibition of increase of neuleus HMGB1."
06/18/2015 - "Natural and synthetic SA derivatives with greater potency for inhibition of HMGB1 were identified, providing proof-of-concept that new molecules with high efficacy against sterile inflammation are attainable. "
11/01/2014 - "(i) The frequency of sterile intra-amniotic inflammation was significantly greater than that of microbial-associated intra-amniotic inflammation [26% (35/135) versus 11% (15/135); (P = 0.005)], (ii) patients with sterile intra-amniotic inflammation delivered at comparable gestational ages had similar rates of acute placental inflammation and adverse neonatal outcomes as patients with microbial-associated intra-amniotic inflammation, and (iii) patients with sterile intra-amniotic inflammation and high AF concentrations of HMGB1 (≥8.55 ng/mL) delivered earlier than those with low AF concentrations of HMGB1 (P = 0.02). "
2. Sepsis (Septicemia)
3. Neoplasms (Cancer)
4. Neuroinflammatory Diseases
5. Necrosis

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Cytokines
3. Interleukin-6 (Interleukin 6)
4. Glycyrrhizic Acid (Glycyrrhizin)
5. Messenger RNA (mRNA)
6. Sirtuin 1
7. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8. NF-kappa B (NF-kB)
9. Lipopolysaccharides
10. DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1. Therapeutics
2. Ligation
3. Punctures
4. Drug Therapy (Chemotherapy)
5. Transplantation