HMGN2 Protein (HMGN2)

08/01/2022 - "This study aimed to establish a lentiviral vector of recombinant HMGN2 gene, establish recombinant T cells (HMGN2-T cells), and observe their anti-tumor effects. "
03/01/2020 - "This study aims to further investigate the potential of HMGN2 in anti-tumor treatment. "
04/01/2018 - "The aim of the present study was to characterize the endogenous expression of HMGN2 in various types of tumor cell. "
01/01/2020 - "Immunohistochemical labeling of HMGN2 in primary ESCC tumor tissue sections (from smokers) showed no detectable expression while strong to moderate staining of HMGN2 was observed in normal esophageal tissues. "
04/01/2018 - "Moreover, supernatants of purified γδT cells were sufficient to kill tumor cells and could be blocked with anti-human HMGN2 antibody. "

01/01/2019 - "In this study, we demonstrate for the first time that HMGN2 is upregulated in UPEC infection of bladder epithelial cell line 5637 (BEC 5637). "
01/01/2018 - "Our study systemically explored the regulatory roles of HMGN2 in BECs barrier function during UPEC infection and suggested different modulations of intracellular and paracellular routes through which UPEC invades the bladder epithelium."
09/01/2016 - "This study suggests a possible therapeutic application for bacterial internalization by targeting HMGN2 in order to treat K. pneumoniae infection. "
12/01/2019 - "Finally, we observed that silencing HMGN2 affected the survival of NTM in macrophage, which might largely relevant to enhanced macrophage polarization into M1 phenotype under the NTM infection. "
01/01/2018 - "Surprisingly, over-expression of HMGN2 promoted disruption of BECs 5637 cells' intercellular junctions by down-regulating tight junction (TJs) components' expression and physical structure under J96 infection. "

04/01/2018 - "Furthermore, the expression of HMGN2 in metastatic oral squamous cell carcinoma tissues was increased compared with that in its non-metastatic counterpart. "
04/01/2018 - "The expression of HMGN2 in oral squamous cell carcinoma tissue was significantly increased compared with the expression in normal tissue. "
04/01/2018 - "HMGN2 was detected in human oral squamous cell carcinoma tissues by immunohistochemical analysis. "
01/01/2014 - "Tca8113 cells, an oral squamous cell carcinoma line, were treated with a variety of HMGN2 protein concentrations and cell growth was analyzed. "
02/01/2013 - "HMGN2 can promote apoptosis of oral squamous cell carcinoma cells."

01/01/2019 - "Therefore, in vitro and in vivo experiments proved that recombinant human HMGN2 could significantly inhibit the proliferation and migration of breast cancer cells, which increased the apoptosis of breast cancer cells and exerted anti-breast cancer effects, which enriched our understanding of the biological roles of HMGN2."
01/01/2019 - "Effect of HMGN2 on proliferation and apoptosis of MCF-7 breast cancer cells."
10/01/2016 - "HDAC6 inhibition both in vitro and in vivo enhances HMGN2 acetylation with a concomitant reduction in Stat5a-mediated signaling, resulting in an inhibition of breast cancer growth. "
10/01/2016 - "HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth."
01/01/2019 - "After the nude mouse model of breast cancer was established, HMGN2 at different concentrations was injected around the tumor tissue at day 1, 3, 5 and 7. We demonstrated that the growth of breast cancer was significantly inhibited when the concentration of HMGN2 reached 15 µg/ml. TUNEL staining showed that the number of apoptotic cells in the 15 µg/ml dose group was significantly higher than that in the control group (P<0.01). "

03/01/2020 - "In particular, HMGN2 was found in our earlier study to be an anti-tumor factor and was seen to impede the metastasis of OS when it was overexpressed. "
04/01/2018 - "These results indicated that HMGN2 may serve an important function in the growth and metastasis of tumor cells."
03/01/2020 - "Our results demonstrated that exogenous HMGN2 plays a role in inhibiting OS metastasis, which could act as a basis for new ideas for future anti-tumor therapy research."