Collagen Type VII

A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.

Also Known As:

Networked: 423 relevant articles (5 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zillikens, Detlef: 29 articles (09/2015 - 07/2002)
2.	Chen, Mei: 26 articles (12/2015 - 01/2002)
3.	Woodley, David T: 22 articles (12/2015 - 01/2002)
4.	Ludwig, Ralf J: 19 articles (09/2015 - 01/2011)
5.	Hashimoto, Takashi: 17 articles (06/2015 - 07/2002)
6.	McGrath, John A: 16 articles (02/2015 - 01/2006)
7.	Uitto, Jouni: 15 articles (12/2015 - 05/2003)
8.	Jonkman, Marcel F: 12 articles (06/2015 - 04/2003)
9.	Schmidt, Enno: 11 articles (09/2015 - 09/2006)
10.	Tolar, Jakub: 10 articles (01/2015 - 01/2009)

Related Diseases

1.	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 08/01/1993 - "Intracytoplasmic retention of type VII collagen and dominant dystrophic epidermolysis bullosa: reversal of defect following cessation of or marked improvement in disease activity." 04/01/1989 - "The results of this study show that the carboxyl-terminal domain of type VII collagen is synthesized, secreted, and deposited at the basement membrane zone in 11 of 12 patients with recessive dystrophic epidermolysis bullosa and suggest that the absence of anchoring fibrils may be due either to deposition of abnormal type VII collagen, reduced levels of normal type VII collagen, defective assembly of type VII collagen into anchoring fibrils, or destruction of the collagenous domain of type VII collagen." 04/01/1989 - "Recent studies showing that type VII collagen is a component of anchoring fibrils suggests that the absence of anchoring fibrils in recessive dystrophic epidermolysis bullosa may be due to a defect in the synthesis, secretion, and deposition of type VII collagen. " 12/01/2015 - "Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice." 06/01/2015 - "Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin blistering disease caused by mutations in COL7A1-encoding type VII collagen (C7). "
2.	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 06/01/2002 - "This study sought to determine if type VII collagen, the epidermolysis bullosa acquisita autoantigen, was present in normal human colon by western blotting and immunofluorescence. " 05/01/2014 - "Epidermolysis bullosa acquisita (EBA) is a rare acquired blistering disorder caused by production of auto-antibody directed against type-VII collagen. " 07/01/2013 - "The type VII collagen (coll VII) enzyme-linked immunosorbent assay (ELISA) has been reported to have high sensitivity (> 93%) and specificity (> 96%) for diagnosing epidermolysis bullosa acquisita (EBA) in patients who are seropositive on indirect immunofluorescence on salt-split skin (SSS). " 07/01/2013 - "Low sensitivity of type VII collagen enzyme-linked immunosorbent assay in epidermolysis bullosa acquisita: serration pattern analysis on skin biopsy is required for diagnosis." 11/15/2011 - "Immunization of mice with type VII collagen, an adhesion protein expressed at the cutaneous basement membrane, induces experimental epidermolysis bullosa acquisita (EBA). "
3.	Autoimmune Diseases (Autoimmune Disease) 06/01/2007 - "Thus, due to improved disease modelling, EBA emerges as an exquisitely instructive model disease to study fundamental, biologically and clinically crucial aspects of antibody-mediated organ-specific autoimmune diseases that extend well beyond the limits of autoimmunity against type VII collagen. " 07/01/2004 - "U-serrated immunodeposition pattern differentiates type VII collagen targeting bullous diseases from other subepidermal bullous autoimmune diseases." 02/01/2010 - "Our present results demonstrate that T cells are required for the initiation of autoimmunity against type VII collagen in experimental epidermolysis bullosa acquisita and provide a basis for developing T cell-directed immunomodulatory strategies for this and related autoimmune diseases." 09/01/2015 - "We established a novel Ab transfer-induced model of epidermolysis bullosa acquisita (EBA), an autoimmune disease characterized by (muco)-cutaneous blistering caused by anti-type VII collagen (COL7) autoantibodies. " 08/15/2014 - "In epidermolysis bullosa acquisita (EBA), an autoimmune disease with severe and chronic skin blistering, autoantibodies are directed against type VII collagen. "
4.	Vesiculobullous Skin Diseases (Subcorneal Pustular Dermatosis) 09/01/2002 - "Dystrophic epidermolysis bullosa (DEB) is a bullous skin disease caused by mutations in the type VII collagen gene (COL7A1). " 09/01/2006 - "Epidermolysis bullosa acquisita (EBA) is a bullous skin disease caused by autoantibodies to type VII collagen. " 03/01/2015 - "Here, efficacy of IVIG monotherapy was compared with corticosteroid treatment in mice with immunization-induced experimental epidermolysis bullosa acquisita (EBA), an autoimmune bullous skin disease characterized by autoantibodies against type VII collagen. " 02/01/2013 - "We noted increased IL-6 levels in human and murine epidermolysis bullosa acquisita (EBA), a prototypic organ-specific autoimmune bullous dermatoses (AIBD) induced by autoantibodies to type VII collagen (COL7). "
5.	Blister (Bulla) 11/01/2013 - "This study aimed to investigate whether ELISA titers fluctuate with EBA disease activity and to validate the clinical significance of checking ELISA values in EBA by monitoring type VII collagen ELISA titers and disease severity, evaluated in terms of numbers of blisters and erosions as a clinical score, over time in three Japanese patients with EBA. " 01/01/2014 - "Dystrophic EB results from mutations in COL7A1 gene coding for type VII collagen leading to blister formation within the dermis. " 11/01/2005 - "Skin biopsies reveal abnormal intraepidermal accumulation of type VII collagen which results in poorly constructed anchoring fibrils and a sublamina densa plane of blister formation. " 02/01/1999 - "This approach revealed a homozygous frameshift mutation, 2470insG, in exon 19 of COL7A1 and resulted in attenuated basement membrane zone expression of type VII collagen, a reduced number of anchoring fibrils at the dermal-epidermal junction, and a sub-lamina densa level of blister formation. " 07/01/1993 - "Indirect immunofluorescence of type VII collagen showed its localization in the blister floor. "

Related Drugs and Biologics

1.	Autoantibodies
2.	Antibodies
3.	Monoclonal Antibodies
4.	Gb3 antigen
5.	Intravenous Immunoglobulins (IVIG)
6.	Luciferases
7.	Genetic Markers (Genetic Marker)
8.	Antigens
9.	Collagen Type IV (Type IV Collagen)
10.	Immunoglobulin A (IgA)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Stem Cell Transplantation
3.	Cell Transplantation
4.	Heterologous Transplantation (Xenotransplantation)
5.	Transplantation (Transplant Recipients)