Collagen Type VII

A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.

Also Known As:

Networked: 597 relevant articles (6 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zillikens, Detlef: 46 articles (01/2022 - 07/2002)
2.	Ludwig, Ralf J: 39 articles (10/2022 - 01/2011)
3.	Chen, Mei: 31 articles (11/2021 - 01/2002)
4.	McGrath, John A: 27 articles (01/2022 - 01/2006)
5.	Hashimoto, Takashi: 24 articles (01/2022 - 07/2002)
6.	Woodley, David T: 24 articles (11/2021 - 01/2002)
7.	Schmidt, Enno: 23 articles (10/2022 - 09/2006)
8.	Uitto, Jouni: 21 articles (11/2021 - 05/2003)
9.	Bieber, Katja: 18 articles (10/2022 - 01/2011)
10.	Tolar, Jakub: 17 articles (01/2022 - 01/2009)

Related Diseases

1.	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 08/01/1993 - "Intracytoplasmic retention of type VII collagen and dominant dystrophic epidermolysis bullosa: reversal of defect following cessation of or marked improvement in disease activity." 04/01/1989 - "The results of this study show that the carboxyl-terminal domain of type VII collagen is synthesized, secreted, and deposited at the basement membrane zone in 11 of 12 patients with recessive dystrophic epidermolysis bullosa and suggest that the absence of anchoring fibrils may be due either to deposition of abnormal type VII collagen, reduced levels of normal type VII collagen, defective assembly of type VII collagen into anchoring fibrils, or destruction of the collagenous domain of type VII collagen." 04/01/1989 - "Recent studies showing that type VII collagen is a component of anchoring fibrils suggests that the absence of anchoring fibrils in recessive dystrophic epidermolysis bullosa may be due to a defect in the synthesis, secretion, and deposition of type VII collagen. " 12/01/2023 - "Recessive dystrophic epidermolysis bullosa (RDEB) is a genodermatosis caused by variants in COL7A1-encoded type VII collagen, a major component of anchoring fibrils. " 11/01/2023 - "Dystrophic epidermolysis bullosa is a rare genetic skin disorder caused by COL7A1 sequence variations that result in type VII collagen deficits and cutaneous and extracutaneous manifestations. "
2.	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 03/23/2021 - "Diagnosis of Epidermolysis Bullosa Acquisita: Multicentre Comparison of Different Assays for Serum Anti-type VII Collagen Reactivity." 10/01/2017 - "Epidermolysis bullosa acquisita is a chronic subepidermal blistering disease associated with autoimmunity to type-VII collagen within anchoring fibrils located at the dermo-epidermal junction. " 06/01/2016 - "Comparison of 3 type VII collagen (C7) assays for serologic diagnosis of epidermolysis bullosa acquisita (EBA)." 01/01/2016 - "Using our serological diagnostic criteria, we selected 105 Japanese patients with epidermolysis bullosa acquisita (EBA), an autoimmune bullous disease (AIBD) reacting with type VII collagen, from our cohort of 5063 AIBD patients. " 05/01/2014 - "Epidermolysis bullosa acquisita (EBA) is a rare acquired blistering disorder caused by production of auto-antibody directed against type-VII collagen. "
3.	Autoimmune Diseases (Autoimmune Disease) 06/01/2007 - "Thus, due to improved disease modelling, EBA emerges as an exquisitely instructive model disease to study fundamental, biologically and clinically crucial aspects of antibody-mediated organ-specific autoimmune diseases that extend well beyond the limits of autoimmunity against type VII collagen. " 07/01/2004 - "U-serrated immunodeposition pattern differentiates type VII collagen targeting bullous diseases from other subepidermal bullous autoimmune diseases." 01/01/2018 - "Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another skin autoimmune disease characterized by anti-type VII collagen AAbs. " 02/01/2010 - "Our present results demonstrate that T cells are required for the initiation of autoimmunity against type VII collagen in experimental epidermolysis bullosa acquisita and provide a basis for developing T cell-directed immunomodulatory strategies for this and related autoimmune diseases." 01/01/2018 - "Epidermolysis bullosa acquisita (EBA) is a rare, but prototypical, organ-specific autoimmune disease, characterized and caused by autoantibodies against type VII collagen (COL7). "
4.	Vesiculobullous Skin Diseases (Subcorneal Pustular Dermatosis) 09/01/2002 - "Dystrophic epidermolysis bullosa (DEB) is a bullous skin disease caused by mutations in the type VII collagen gene (COL7A1). " 09/01/2006 - "Epidermolysis bullosa acquisita (EBA) is a bullous skin disease caused by autoantibodies to type VII collagen. " 02/01/2013 - "We noted increased IL-6 levels in human and murine epidermolysis bullosa acquisita (EBA), a prototypic organ-specific autoimmune bullous dermatoses (AIBD) induced by autoantibodies to type VII collagen (COL7). " 03/01/2015 - "Here, efficacy of IVIG monotherapy was compared with corticosteroid treatment in mice with immunization-induced experimental epidermolysis bullosa acquisita (EBA), an autoimmune bullous skin disease characterized by autoantibodies against type VII collagen. "
5.	Blister (Bulla) 11/01/2013 - "This study aimed to investigate whether ELISA titers fluctuate with EBA disease activity and to validate the clinical significance of checking ELISA values in EBA by monitoring type VII collagen ELISA titers and disease severity, evaluated in terms of numbers of blisters and erosions as a clinical score, over time in three Japanese patients with EBA. " 12/01/2023 - "Blister fluid-derived MSCs were genetically modified and injected into skins of type VII collagen-deficient neonatal mice transplanted onto immunodeficient mice, resulting in continuous and widespread expression of type VII collagen at the dermal-epidermal junction, particularly when administered into blisters. " 01/01/2014 - "Dystrophic EB results from mutations in COL7A1 gene coding for type VII collagen leading to blister formation within the dermis. " 06/01/2011 - "Healthy donor cells from the hematopoietic graft migrate to the injured skin; simultaneously, there is an increase in the production of collagen type VII, increased skin integrity, and reduced tendency to blister formation. " 11/01/2005 - "Skin biopsies reveal abnormal intraepidermal accumulation of type VII collagen which results in poorly constructed anchoring fibrils and a sublamina densa plane of blister formation. "

Related Drugs and Biologics

1.	Autoantibodies
2.	Antibodies
3.	Proteins (Proteins, Gene)
4.	Monoclonal Antibodies
5.	Gentamicins (Gentamicin)
6.	Gb3 antigen
7.	Intravenous Immunoglobulins (IVIG)
8.	Solutions
9.	Luciferases
10.	Genetic Markers (Genetic Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Stem Cell Transplantation
4.	Cell- and Tissue-Based Therapy (Cell Therapy)
5.	Cell Transplantation