Collagen Type IV (Type IV Collagen)

A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.

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Networked: 2206 relevant articles (22 outcomes, 244 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sado, Yoshikazu: 17 articles (03/2013 - 01/2002)
2.	Kalluri, Raghu: 13 articles (11/2009 - 12/2003)
3.	Naito, Ichiro: 10 articles (09/2015 - 03/2002)
4.	Gross, Oliver: 10 articles (09/2014 - 02/2003)
5.	Ninomiya, Yoshifumi: 10 articles (03/2013 - 03/2002)
6.	Pusey, Charles D: 9 articles (05/2015 - 05/2003)
7.	Makino, Hirofumi: 9 articles (01/2015 - 01/2002)
8.	Kashtan, Clifford E: 9 articles (01/2011 - 05/2003)
9.	Reynolds, John: 8 articles (05/2015 - 05/2003)
10.	Maeshima, Yohei: 8 articles (01/2015 - 12/2003)

Related Diseases

1.	Fibrosis (Cirrhosis) 12/01/2003 - "Here we report that treatment with rhBMP-7 leads to improved renal function, histology, and survival in mice deficient in the alpha3-chain of type IV collagen and MRL/MpJlpr/lpr lupus mice, two genetic models for chronic renal injury and fibrosis. " 11/01/1999 - "In study 1 the presence of sclerosing fibrosis, deposition of interstitial type IV collagen, and the number of myofibroblasts (alphaSMA-positive cells) was greater in the PS biopsies than biopsies from all control groups (p < 0.002). " 11/01/1995 - "Studies on the level of serum type IV collagen (IV C) have usually been focused on the disease with diffuse hepatic fibrosis. " 01/01/2015 - "On day 28, renal fibrosis was clearly shown with increased type IV collagen and TGF-β. " 10/05/2014 - "Collectively, these results suggest that COX-2 may be involved in the expression of HSP47 and type IV collagen through the phosphorylation of ERK and JNK, accelerating renal interstitial fibrosis."
2.	Diabetic Nephropathies (Diabetic Nephropathy) 08/01/2010 - "The aim of this study was to determine the role of urinary type IV collagen in predicting development and progression of early diabetic nephropathy and deterioration of renal function in a longitudinal study. " 06/01/2010 - "This study was carried out to determine whether urinary type IV collagen (uIV) can serve as an indicator of diabetic nephropathy. " 01/01/2002 - "[A study about normal values of urinary type IV collagen concentration--aim at constructing a diagnostic guideline for diabetic nephropathy]." 08/01/2001 - "Whereas increased urinary excretion of type IV collagen, which is believed to reflect renal overproduction of this extracellular matrix protein in early diabetic nephropathy, has been confirmed in several studies, examination of serum concentrations of this analyte has yielded conflicting results. " 03/05/2015 - "Camel milk attenuates the biochemical and morphological features of diabetic nephropathy: inhibition of Smad1 and collagen type IV synthesis."
3.	Neoplasms (Cancer) 01/01/2013 - "In this study, the cellular effects of type IV collagen produced by the cancer cells were characterized. " 06/01/2004 - "MMP-2 and MMP-9 are capable of digesting collagen type IV. Numerous studies have demonstrated an association between increased MMP-2 and -9 expression and tumor progression in various tumors. " 12/19/2003 - "Canstatin, the non-collagenous 1 (NC1) domain of alpha2 chain of type IV collagen, was identified as an inhibitor of angiogenesis and tumor growth by Kamphaus et al. Our previous studies showed that canstatin-N, the N-terminal 1-89 amino acid fragment of canstatin, inhibited the neovascularization in a dose-dependent manner as tested by CAM assay. " 11/01/2003 - "Confocal microscopic studies revealed that basement membrane identified by type IV collagen immunoreactivity covered >99.9% of the surface of blood vessels in the three tumors, just as in normal pancreatic islets. " 05/01/2001 - "Bone morphogenetic protein-2 (BMP-2) has recently been proposed to be involved in the calcification of tumor cells and recent electron microscopic studies demonstrated the presence of type IV collagen in PBs. "
4.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2011 - "In the present study, we developed an ELISA for the quantification of a neoepitope generated by MMP degradation of type IV collagen and evaluated the association of this neoepitope with liver fibrosis in two animal models. " 12/28/2005 - "The morphological and serum HA, type IV collagen, and LN are changed in DMN-induced liver fibrosis in rats." 01/28/2005 - "The increase in serum levels of all markers, particularly HA, was correlated with the progression of liver fibrosis (for type IV collagen, F = 9.076, P<0.0001; for PIIIP, F = 9.636, P<0.0001; for HA, F = 13.128, P<0.0001; and for YKL-40, F = 8.016, P<0.0001). " 04/01/2002 - "The serum type IV collagen level was significantly elevated in patients with liver cirrhosis. " 02/01/1998 - "A good relationship between the degree of liver fibrosis and the Type IV collagen serum level was found (r = 0.68; P < 0.005). "
5.	Proteinuria 05/01/2015 - "We evaluated the renin-angiotensin system in 4- and 7-week-old homozygous for collagen, type IV, α3 gene (Col4A3(-/-)) and wild-type mice, a model of AS characterized by proteinuria and progressive renal injury. " 08/01/2010 - "Our results indicate that high urinary excretion of type IV collagen is associated with deterioration of renal function in type 2 diabetic patients without overt proteinuria." 08/01/2010 - "Association between urinary type IV collagen level and deterioration of renal function in type 2 diabetic patients without overt proteinuria." 08/01/2010 - "Baseline urinary type IV collagen excretion was negatively correlated with the subsequent GFR change (r(s)=-0.39, p=0.04) in our cohort of 30 type 2 diabetic patients with proteinuria. " 08/01/2010 - "Urinary type IV collagen excretion predicts subsequent declining renal function in type 2 diabetic patients with proteinuria."

Related Drugs and Biologics

1.	Laminin (Merosin)
2.	Collagen Type III (Type III Collagen)
3.	Hyaluronic Acid (Hyaluronan)
4.	Fibronectins (Fibronectin)
5.	Collagen Type I (Type I Collagen)
6.	Biological Markers (Surrogate Marker)
7.	Tissue Inhibitor of Metalloproteinase-1
8.	Antibodies
9.	Collagen
10.	Transforming Growth Factor beta (TGF-beta)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Transplants (Transplant)
5.	Transplantation (Transplant Recipients)