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Collagen Type X

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A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.

Also Known As:

Collagen Type X, alpha1 Chain; Collagen Type X, alpha1 Subunit; Collagen alpha1(X); Procollagen Type X; Type X Collagen; Type X Procollagen; Collagen, Type X; Procollagen, Type X; Type X, Procollagen

Networked: 192 relevant articles (2 outcomes, 13 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Scleroproteins: 26
    - Extracellular Matrix Proteins: 1319
      - Collagen: 31722
        Non-Fibrillar Collagens: 9
        Collagen Type X: 192

Experts

1.	Antoniou, John: 12 articles (07/2015 - 10/2005)
2.	Mwale, Fackson: 11 articles (07/2015 - 10/2005)
3.	Wang, Hong Tian: 5 articles (07/2015 - 09/2006)
4.	Kawaguchi, Hiroshi: 5 articles (10/2014 - 03/2004)
5.	Petit, Alain: 4 articles (01/2011 - 10/2005)
6.	Nakamura, Kozo: 4 articles (06/2010 - 03/2004)
7.	Drissi, Hicham: 4 articles (07/2006 - 09/2004)
8.	Schwarz, Edward M: 4 articles (07/2006 - 06/2002)
9.	O'Keefe, Regis J: 4 articles (07/2006 - 06/2002)
10.	Madry, Henning: 3 articles (06/2015 - 08/2009)

Related Diseases

1.	Hypertrophy 02/01/1985 - "These results are consistent with our previous biochemical studies suggesting that, in cartilage, type X collagen is specifically a product of that population of chondrocytes which have undergone hypertrophy." 07/01/2015 - "However, MSCs from OA patients have been shown to constitutively express collagen type X (COL-X), a marker of late-stage chondrocyte hypertrophy. " 06/01/2014 - "A significant correlation between the expression of type X collagen, a marker for chondrocyte hypertrophy and cartilage mineralization was observed. " 01/01/2014 - "However, how the type X collagen gene is regulated during chondrocyte hypertrophy has not been fully elucidated. " 01/01/2014 - "Meanwhile, as a specific marker of hypertrophic chondrocytes, the type X collagen gene (COL10A1) is also critical for endochondral bone formation, as mutation and altered COL10A1 expression are often accompanied by abnormal chondrocyte hypertrophy in many skeletal diseases. "
2.	Scoliosis 06/01/2010 - "The different expression of type X collagen and Runx2 between the convex and concave side of vertebral growth plate in scoliosis may help to improve our understanding of the role that growth plate tissue play in the development or progression of idiopathic scoliosis. " 06/01/2010 - "Expression of Runx2 and type X collagen in vertebral growth plate of patients with adolescent idiopathic scoliosis." 12/01/2004 - "Investigating the expression of type X collagen in the peak disc and the lower end disc of 21 IS patients, the peak disc of 16 congenital scoliosis (CS) and the lumbar disc of 3 normal people (according with the principle of medical ethnics) by reverse transcript polymerase chain reaction. " 12/01/2004 - "To observe the characteristics of gene expression of type X collagen in the cartilage of end-plate and the fibrous annulus in the intervertebral disc of idiopathic scoliosis (IS) patients. " 12/01/2004 - "[Gene expression of type X collagen in the intervertebral disc of idiopathic scoliosis patients]."
3.	Osteoarthritis 01/01/2011 - "The constitutive expression of type x collagen in mesenchymal stem cells from osteoarthritis patients is reproduced in a rabbit model of osteoarthritis." 01/01/2006 - "The gene encoding type X collagen is expressed specifically by hypertrophic chondrocytes and up regulated during osteoarthritis. " 03/01/2004 - "In a mouse model of osteoarthritis, activated p38 expression as well as type X collagen staining was detected in osteochondrophytes and marginal synovial cells. " 11/01/2001 - "In osteoarthritis, chondrocyte differentiation is characterized by the expression of type X collagen. " 02/01/2001 - "The locations in the murine knee joints prone to develop osteoarthritis (OA) did not preferentially express increased amounts of type X collagen. "
4.	Rickets (Rachitis) 07/01/1990 - "As a prelude to determining what, if any, alterations occur in the distribution of type X collagen in growth plates of poultry with rickets or tibial dyschondroplasia, our objective in the current study was to determine the distribution of type X collagen in the proximal tibiotarsi of broiler chickens and turkeys from 1 day of age through physeal closure. " 10/01/1989 - "Northern hybridization of mRNA and biosynthetic studies have confirmed that type X collagen synthesis in rickets is also decreased. " 10/01/1989 - "These observations provide additional evidence that type X collagen is involved in the process of cartilage mineralization and also suggest that the partial recovery of type X collagen synthesis in normocalcemic rickets may be related to the elevated plasma concentration of calcium. " 10/01/1989 - "In hypocalcemic rickets, the level of type X collagen mRNA is reduced by 80% whereas the level of type X collagen mRNA is only reduced by 50% in normocalcemic rickets. " 07/15/1988 - "It is likely that in rickets the overproduction of Type X collagen may be a compensatory mechanism by which the hypertrophic chondrocyte attempts to provide a maximum area of calcifiable matrix for the calcium-depleted serum."
5.	Neoplasms (Cancer) 05/01/2015 - "According to our results, the N-terminal globular domain of the type X collagen (COL10A1) gene and transmembrane protein 100 (TMEM100) gene were identified to be the most significant DEGs in tumor tissue compared with the adjacent normal tissues. " 06/01/1997 - "This is the first description of the focal expression of collagen type X by neoplastic chondrocytes in situ and its incorporation into the extracellular matrix of cartilaginous tumors. " 12/01/1996 - "The unusual scarcity of its extracellular and the multifocal expression of type X collagen marks clear cell chondrosarcoma as a chondrosarcoma tumor entity of a particular cell differentiation pattern. " 01/01/1995 - "Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen." 01/01/1992 - "These results indicate that the type of collagen changes from type II to type X in the hypertrophic region and the type X collagen may be synthesized by hypertrophic tumor cells. "

Related Drugs and Biologics

1.	Osteopontin
2.	Alkaline Phosphatase
3.	Collagen
4.	Intercellular Signaling Peptides and Proteins (Growth Factors)
5.	Messenger RNA (mRNA)
6.	Proteoglycans (Proteoglycan)
7.	Collagen Type II (Type II Collagen)
8.	Aggrecans (Aggrecan)
9.	Matrix Metalloproteinase 13
10.	Collagen Type I (Type I Collagen)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Transplants (Transplant)