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Collagen Type V (Type V Collagen)

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A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.

Also Known As:

Type V Collagen; Collagen Type V, alpha1 Chain; Collagen Type V, alpha1 Subunit; Collagen Type V, alpha2 Chain; Collagen Type V, alpha2 Subunit; Collagen Type V, alpha3 Chain; Collagen Type V, alpha3 Subunit; Collagen alpha1(V); Collagen alpha2(V); Collagen alpha3(V); Procollagen Type V; Type V Procollagen; Collagen, Type V; Procollagen, Type V; V Procollagen, Type

Networked: 157 relevant articles (1 outcomes, 11 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Wilkes, David S: 11 articles (05/2015 - 02/2002)
2.	Greenspan, Daniel S: 7 articles (03/2013 - 11/2007)
3.	Cummings, Oscar W: 7 articles (03/2013 - 02/2002)
4.	Burlingham, William J: 6 articles (01/2013 - 11/2007)
5.	Teodoro, Walcy R: 5 articles (05/2015 - 01/2004)
6.	Parra, Edwin Roger: 5 articles (05/2015 - 07/2006)
7.	Mickler, Elizabeth A: 5 articles (10/2013 - 03/2007)
8.	Smith, Gerald N: 5 articles (01/2013 - 02/2002)
9.	Haynes, Lynn D: 5 articles (01/2013 - 11/2007)
10.	Jankowska-Gan, Ewa: 5 articles (01/2013 - 11/2007)

Related Diseases

1.	Atherosclerosis 10/29/2010 - "Interleukin-17-dependent autoimmunity to collagen type V in atherosclerosis." 11/23/2012 - "Aberrant expression of the type V collagen α1(V) chain can underlie the connective tissue disorder classic Ehlers-Danlos syndrome, and autoimmune responses against the α1(V) chain are linked to lung transplant rejection and atherosclerosis. " 04/01/1993 - "These results suggest that, in the event of human atherosclerosis, TGS-beta 1 is most effective in enhancing collagen synthesis, and PDGF modulates collagen metabolism by stimulating a cell division of smooth muscle cells with a resultant increase of collagenous protein, especially of type V collagen." 04/01/1994 - "These results suggest that the elevated levels of TGF-beta 1 in the vessel wall during atherosclerosis may be, in part, responsible for the increase in type V collagen that typifies advanced fibrotic lesions."
2.	Neoplasms (Cancer) 04/01/2010 - "Association between decreases in type V collagen and apoptosis in mouse lung chemical carcinogenesis: a preliminary model to study cancer cell behavior." 06/01/2003 - "Our data validate the T47-D line as a suitable in vitro model for further and more detailed studies on the molecular mechanisms of the death response induced by type V collagen on mammary tumor cells." 05/01/1989 - "Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components." 01/01/1987 - "These data indicate that the increase of type V collagen content is part of the disturbed tissue interactions between dermis and epidermis that facilitate tumor development." 01/01/1987 - "When TPA treatment was discontinued before tumor development no increase of type V collagen was observed. "
3.	Carcinoma (Carcinomatosis) 04/01/2011 - "When used as a substrate, type V collagen restrains growth and invasion, and affects gene expression of 8701-BC ductal infiltrating carcinomas cells. " 04/01/2011 - "Type V collagen is known to be over-deposited in the stroma of ductal infiltrating carcinomas of the breast. " 09/01/1991 - "A comparison of spreading and motility behaviour of 8701-BC breast carcinoma cells on type I, I-trimer and type V collagen substrata. " 03/01/1990 - "Type V collagen is one of the minor components of the extracellular matrix (ECM) whose content is increased in cases of ductal infiltrating carcinomas of the breast. " 03/01/1990 - "Adhesion, growth and cytoskeletal characteristics of 8701-BC breast carcinoma cells cultured in the presence of type V collagen."
4.	Cicatrix (Scar) 10/01/2012 - "All type V collagen defects were identified within a group of 102 patients fulfilling all major clinical Villefranche criteria, that is, skin hyperextensibility, dystrophic scarring and joint hypermobility. " 09/01/1986 - "Collagen extraction studies revealed both an absolute and relative increase in Type V collagen in the scar carcinomas, compared with that found in the apical scars. " 05/01/2011 - "Finding type III collagen, type V collagen, and myofibroblasts characteristic of fibrosis in the scars, finally reversed the original SC concept. " 05/01/1995 - "An inversion of the relation between the I and III collagen types in favour of the latter, high level of type V collagen and permanent presence of fibronectin were characteristic for the scar tissue. " 09/01/2007 - "In sarcomatoid renal cell carcinoma, there was diffuse pericellular expression of collagen type V and patchy pericellular expression of collagen type VI, whereas early spindle cell change tumors showed patchy pericellular staining with antibodies to collagen type V. Collagen type VI expression in early spindle cell change was largely confined to the vascular adventitia and areas of scarring, although very occasional foci of faint interstitial staining were also seen. "
5.	Breast Neoplasms (Breast Cancer) 06/01/2003 - "T47-D cells and type V collagen: a model for the study of apoptotic gene expression by breast cancer cells." 02/01/2005 - "Type V collagen regulates the expression of apoptotic and stress response genes by breast cancer cells." 06/01/2003 - "We have previously reported that type V collagen is a poorly adhesive, anti-proliferative and motility-inhibitory substrate for the 8701-BC breast cancer cell line, which also triggers DNA fragmentation and impairs survival of the same cell line. " 06/01/1992 - "Adhesion of 8701-BC breast cancer cells to type V collagen and 67 kDa receptor." 05/01/2013 - "Type V collagen and protein kinase C η down-regulation in 8701-BC breast cancer cells."

Related Drugs and Biologics

1.	Collagen
2.	Collagen Type I (Type I Collagen)
3.	Fibronectins (Fibronectin)
4.	Laminin (Merosin)
5.	Monoclonal Antibodies
6.	Vitronectin
7.	Ammonium Sulfate
8.	Collagen Type III (Type III Collagen)
9.	Collagen Type IV (Type IV Collagen)
10.	Collagen Type V (Type V Collagen)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Lung Transplantation
3.	Prostheses and Implants (Prosthesis)
4.	Heart Transplantation (Grafting, Heart)
5.	Electroacupuncture