Collagen Type III (Type III Collagen)

A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.

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Networked: 1383 relevant articles (27 outcomes, 153 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Karsdal, Morten A: 9 articles (07/2015 - 10/2010)
2.	Risteli, J: 7 articles (05/2011 - 07/2000)
3.	Risteli, Juha: 7 articles (10/2009 - 11/2002)
4.	Gottdiener, John S: 6 articles (10/2015 - 07/2009)
5.	Kizer, Jorge R: 6 articles (10/2015 - 05/2014)
6.	Barasch, Eddy: 6 articles (10/2015 - 07/2009)
7.	Ix, Joachim H: 6 articles (10/2015 - 05/2014)
8.	Capelozzi, Vera L: 6 articles (10/2013 - 01/2006)
9.	Rocco, Patricia R M: 6 articles (10/2013 - 01/2006)
10.	Vassiliadis, Efstathios: 6 articles (01/2013 - 10/2010)

Related Diseases

1.	Fibrosis (Cirrhosis) 03/01/2009 - "Then we studied 21 patients liver biopsies by immunohistochemical analysis of alpha-smooth muscle actin (alpha-SMA) and collagen type III. A significant improvement in HAI fibrosis staging was detected after therapy in all sustained viral responders (SVR) and non-responders (NR) patients. " 05/01/2015 - "In the present study the serum concentration of procollagen type III amino terminal peptide (PIIIP) was measured to determine the value of this peptide as a potential marker of ventricular fibrosis in hypertensive patients, particularly those with LVH. " 09/01/2015 - "At the end of the regenerative process, collagen type III deposition was increased compared to wild-type muscles and internal controls, indicating the initiation of fibrosis. " 12/01/2014 - "Associations between N-terminal procollagen type III, fibrosis and echocardiographic indices in dogs that died due to myxomatous mitral valve disease." 12/01/2014 - "TRH overexpression induced a significant increase in fibrosis, evident in the increase of collagen type III expression accompanied by a significant increase in extracellular matrix expansion. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 12/01/2000 - "ASO were effective in inhibiting the expression of the procollagen type III gene in the HSC which is well known to play a critical role in liver fibrosis." 01/01/2012 - "The aim of the present study was to develop a model of liver fibrosis combining ex vivo tissue culture of livers from CCl(4) treated animals with an ELISA detecting a fragment of type III collagen generated in vitro by MMP-9 (C3M), known to be associated with liver fibrosis and to investigate cAMP modulation of MMP activity and liver tissue turnover in this model. " 10/01/2010 - "The current study investigated whether a novel enzyme-linked immunosorbent assay (ELISA) assay specifically measuring an MMP-9-cleaved sequence of type III collagen located at position 610 (CO3-610C) may be used as a marker of liver fibrosis. " 07/01/1996 - "The purpose of the present study was to prove the significance of procollagen type-III-peptide concentrations in serum as a non-invasive marker of liver fibrogenesis in an animal model that best resembles progressive human liver fibrosis. " 05/01/1993 - "Study of serum procollagen type III peptide in patients with hepatic cirrhosis from a clinical point of view."
3.	Liver Diseases (Liver Disease) 06/01/1991 - "Serum hyaluronate and type III procollagen aminoterminal propeptide concentration in chronic liver disease. " 06/01/1989 - "Clinical significance of serum type-III procollagen aminopropeptide in hepatitis B virus-related liver diseases." 07/01/1987 - "[Serum level of N-terminal peptide of procollagen type III in chronic liver disease]." 04/01/1987 - "Considering, that S-P-III-NP, in contrast to the conventional laboratory variables, reflects the metabolism of type III collagen, it is assumed that determination of S-P-III-NP may provide new information on fibrogenesis in viral liver disease." 10/01/1986 - "Increased urine level of amino-terminal peptide derivatives of type III procollagen in patients with liver diseases."
4.	Wounds and Injuries (Trauma) 04/01/2014 - "When the scaffolds were applied to full thickness wounds in vivo, reduced wound contraction, improved collagen type III/I ratios and a significantly higher matrix metalloproteinase (MMP)-8: tissue inhibitor of metalloproteinase (TIMP)-1 ratio were detected when the scaffolds were functionalized with miR-29B. " 02/01/2014 - "The study group was superior to the control group in terms of inflammatory scoring, type I/type III collagen ratio and wound contraction rates. " 01/01/1992 - "In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to elucidate the specificity of the histochemical staining method. " 08/01/2014 - "A score summarising the expression of all markers positively correlated significantly with an increased percentage of collagen type III (green) in the mesh wound. " 01/01/2011 - "Type III collagen (Col3), expressed in early granulation tissue, has been proposed to play a prominent role in cutaneous wound repair, although little is known about its role in this process. "
5.	Chronic Hepatitis (Chronic Active Hepatitis) 01/01/1987 - "However, these preliminary results suggest that procollagen type III can distinguish active disease from chronic active hepatitis in remission.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1987 - "Serial determinations of the amino-terminal peptide of type III procollagen in severe chronic active hepatitis." 04/01/1985 - "Variation in serum type III procollagen peptide with age in healthy subjects and its comparative value in the assessment of disease activity in children and adults with chronic active hepatitis." 01/01/1988 - "Serum levels of procollagen type III peptide were measured by radioimmunoassay in 76 consecutive patients with acute viral hepatitis, in order to see if this index of hepatic fibrogenesis is also predictive for the development of chronic active hepatitis in high-risk patients. " 01/01/1987 - "Serum type III procollagen peptide concentrations in severe chronic active hepatitis: relationship to cirrhosis and disease activity."

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Collagen Type IV (Type IV Collagen)
3.	Collagen
4.	Collagen Type I (Type I Collagen)
5.	Laminin (Merosin)
6.	procollagen Type III-N-terminal peptide (PIIP)
7.	Transforming Growth Factor beta1 (TGF beta 1)
8.	Transforming Growth Factors (Transforming Growth Factor)
9.	Hydroxyproline (4 Hydroxyproline)
10.	Spironolactone (Aldactone)

Related Therapies and Procedures

1.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
2.	Pancreatectomy
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Stents