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Collagen Type II (Type II Collagen)

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A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.

Also Known As:

Type II Collagen; Collagen Type II, alpha1 Chain; Collagen Type II, alpha1 Subunit; Collagen alpha1(II); Procollagen Type II; Type II Procollagen; Collagen, Type II; II Procollagen, Type; Procollagen, Type II

Networked: 2072 relevant articles (87 outcomes, 218 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Holmdahl, Rikard: 71 articles (08/2015 - 01/2002)
2.	Nandakumar, Kutty Selva: 32 articles (08/2015 - 09/2002)
3.	Kang, Andrew H: 18 articles (06/2012 - 01/2002)
4.	Straub, Rainer H: 16 articles (11/2015 - 04/2005)
5.	Kim, Ho-Youn: 15 articles (02/2015 - 04/2002)
6.	Garnero, P: 15 articles (02/2011 - 05/2001)
7.	Myers, Linda K: 14 articles (10/2015 - 01/2002)
8.	Burkhardt, Harald: 14 articles (06/2014 - 09/2002)
9.	Rosloniec, Edward F: 14 articles (01/2012 - 01/2002)
10.	Poole, A R: 14 articles (05/2008 - 05/2000)

Related Diseases

1.	Arthritis (Polyarthritis) 08/01/2006 - "In the type II collagen-induced arthritis model, we observed a significant reduction in clinical scores (p < 0.01) in three independent experiments and diminished joint pathology (p < 0.005) in PKC-theta-deficient compared with wild-type littermates. " 01/01/2000 - "Compound 19a (ED40 = 3.6 mg/kg in established AA) possessed good therapeutic efficacy against type II collagen-induced arthritis in DBA/1J mice with doses of 30 and 100 mg/kg, suggesting the development of 19a (designated T-614) as a prospective disease-modifying antirheumatic agent. " 06/01/1985 - "Despite no difference in clearance of anti-type II collagen antibody after transfer between them, the passively transferred arthritis in rnu/rnu rats was significantly enhanced and prolonged in comparison with that in rnu/+ rats. " 05/01/2010 - "Previous research has shown that undenatured type II collagen is effective in the treatment of arthritis. " 07/25/2002 - "Gene therapy of IL-ira via non-virus eukaryotic expression vactor, especially by gene gun, is effective in treating arthritis induced by type II collagen."
2.	Rheumatoid Arthritis 01/17/2006 - "Chicken type II procollagen (ccol2a1) has become as an important oral tolerance protein for effective treatment of rheumatoid arthritis. " 03/01/1998 - "Although effective in animal models, attempts to treat rheumatoid arthritis with orally administered type II collagen have proven elusive. " 06/01/2013 - "Recently, type II collagen (CII) was found to be effective clinically for treatment of rheumatoid arthritis (RA). " 11/01/2013 - "Earlier studies have reported the efficacy of type II collagen (C II) in treating rheumatoid arthritis (RA). " 10/01/1998 - "Based on the results of two recently published, randomized, double-blind and placebo-controlled studies, a possible improvement in rheumatoid arthritis disease activity after oral tolerization with triple helical collagen type II has been suggested. "
3.	Experimental Arthritis 09/01/2010 - "The therapeutic mechanisms and efficacy of low-dose MTX and the oral tolerance protein natural chicken type II collagen (nCCII) were compared in vitro and in vivo using an established collagen-induced arthritis (CIA) rat model. " 07/10/1996 - "We then tested aerosolization of a different autoantigen in a different disease model and found that aerosolization of type II collagen was effective in suppressing collagen-induced arthritis. " 04/01/2008 - "Oestrogen exhibits type II collagen protective effects and attenuates collagen-induced arthritis in rats." 11/01/2013 - "Water-soluble undenatured type II collagen ameliorates collagen-induced arthritis in mice." 12/01/1989 - "Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis."
4.	Osteoarthritis 01/01/2009 - "Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial." 02/01/2005 - "The objective of this study was to determine whether collagen type II breakdown products in synovial fluid (SF), detected by an enzyme-linked immunoassay, represent a useful marker for early events in osteoarthritis (OA) in the rabbit medial meniscectomy model. " 11/01/1999 - "This study employed immunohistochemistry to investigate the pattern of type II collagen (CII) degradation in an acute injury model of osteoarthritis. " 08/01/1991 - "Additionally, the application of techniques of molecular biology to the study of the genetics of familial osteoarthritis has identified hereditary defects in type II collagen that appear to predispose to the early development of osteoarthritis in affected family members. " 01/01/2016 - "MMP-13 is implicated in the degradation of type II collagen, the main structural protein of articular cartilage, contributing to the development of osteoarthritis and inflammatory diseases. "
5.	Inflammation 12/01/2015 - "The advanced therapeutic strategy showed that neo-hyaline cartilage formation with enriched collagen type II, higher glycosaminoglycan, integrating subchondral bone formation and modest inflammation." 01/01/2014 - "Compounds 5j, 5k and 5m decrease the expression of type II collagen in a dose dependent manner; similarly 5l decrease the COX-2 expression of rabbit articular chondrocytes in a dose dependent manner possessing potent anti-inflammatory potential while some of derivatives including 5c, 5e, 5g and 5h cause inflammation. " 11/01/2011 - "Synovial inflammation and immune responses against type II collagen were similar in PIV(-/-) K14 CIITA-transgenic mice and control mice with CIA, but bone erosion was significantly reduced in the absence of PIV. " 07/01/2008 - "In serial observations of tissue pathology, we could note the inflammation of synovium developing a week after the injection of type II collagen. " 05/01/2008 - "casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation."

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Collagen Type I (Type I Collagen)
4.	Collagen
5.	Biological Markers (Surrogate Marker)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Aggrecans (Aggrecan)
8.	Methotrexate (Mexate)
9.	cartilage matrix protein
10.	Interleukin-10 (Interleukin 10)

Related Therapies and Procedures

1.	Oral Administration
2.	Intra-Articular Injections
3.	Intranasal Administration
4.	Transplants (Transplant)
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)