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Collagen Type I (Type I Collagen)

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The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Also Known As:

Type I Collagen; Collagen Type I, alpha1 Chain; Collagen Type I, alpha1 Subunit; Collagen Type I, alpha2 Subunit; Collagen alpha1(I); Collagen alpha2(I); Pro alpha 1 Collagen; Pro alpha 2 Collagen; Type 1 Collagen; Type I Procollagen; alpha-2 Type 1 Collagen; alpha1 Type 1 Collagen; alpha2 Type 1 Collagen; Collagen, Type 1; Collagen, Type I; Procollagen, Type I; Collagen Type I, alpha2 Chain; Procollagen Type I

Networked: 4327 relevant articles (81 outcomes, 434 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Garnero, P: 24 articles (02/2011 - 02/2000)
2.	Marini, Joan C: 23 articles (08/2014 - 02/2003)
3.	Risteli, J: 22 articles (05/2011 - 04/2000)
4.	Garnero, Patrick: 18 articles (09/2015 - 05/2004)
5.	Terpos, Evangelos: 18 articles (01/2014 - 01/2003)
6.	Leikin, Sergey: 16 articles (10/2014 - 03/2003)
7.	Risteli, Juha: 16 articles (08/2014 - 11/2002)
8.	Cabral, Wayne A: 16 articles (06/2014 - 03/2003)
9.	Glorieux, Francis H: 15 articles (10/2015 - 07/2002)
10.	Iwamoto, Jun: 14 articles (10/2015 - 01/2002)

Related Diseases

1.	Fibrosis (Cirrhosis) 06/01/2011 - "Here we hypothesize that uncovering a molecular mechanism that enables us to switch off type I collagen may prove beneficial in treating fibrosis. " 01/01/2015 - "PEP-1-SOD1 suppressed MCF proliferation and differentiation and reduced production of collagen type I and III. Therefore, PEP-1-SOD1 fusion protein may be a potential novel therapeutic agent for cardiac fibrosis." 08/01/2009 - "Texture analysis of microscopic images along with fibrosis index calculation showed improvement in the quality of type I collagen distribution and its quantity after administration of ZSC extract. " 12/01/2014 - "Studies have shown that Notch signaling participates in the progression of fibrosis; however, whether Notch signaling is involved in regulating type I collagen expression in airway fibroblasts remains unclear. " 11/15/2014 - "Fibrocytes have been proposed as an important direct contributor of type I collagen deposition during fibrosis based largely on fate-mapping studies. "
2.	Bone Resorption 05/01/1999 - "The urinary amino-terminal (NTXtrade mark) and carboxy-terminal (CrossLapstrade mark) cross-linked fragments of type I collagen, both markers of bone resorption, showed a marked decrease (25-50%) with both regimens during the period of active treatment. " 01/01/2001 - "A significant reduction in C-terminal telopeptide type 1 collagen (1CTP) indicated decreased bone resorption 1 year after surgery (p < 0.05). " 02/09/2004 - "Although not optimized, a selected inhibitor was effective in attenuating type I collagen hydrolysis in a surrogate assay of bone resorption." 12/01/2001 - "An ELISA procedure was developed to evaluate the efficacy of this monoclonal to measure bone resorption and characterize urinary degradation products of C-terminal type I collagen. " 12/01/2004 - "The effect of storage temperature on stability of bone resorption markers have not been subject of systematically investigation, and therefore the present study was set out to determine the stability of C-telopeptides of type I collagen (CTX) in serum and plasma samples stored frozen for 3 years. "
3.	Wounds and Injuries (Trauma) 03/01/1996 - "At 14 days, the amount of type-I collagen in TCC-injected wounds was significantly greater than that in other wounds. " 07/01/2015 - "At day 7, post infliction of excision wound, histomorphological, and histochemical studies revealed more fibroblasts and Type 1 collagen deposits in wound site sections of rats treated with both 10 and 5% MCJBEO while those of the control showed more inflammatory cells and fewer Type 1 collagen deposits. " 07/01/2013 - "The purpose of this study was to test the performance of a flowable gel made of human recombinant type I collagen (rhCollagen) produced in transgenic tobacco plants, indicated for the treatment of acute, chronic, and tunneled wounds. " 02/01/2011 - "Recent studies show that bone marrow (BM)-derived cells migrating into a dermal wound promote healing by producing collagen type I. However, their contribution to the repair process has not been fully verified yet. " 02/01/2000 - "To study the dynamic changes in the dermal cell cycles contents of hydroproline and ratios of collagen type I/III in the burned wound. "
4.	Neoplasm Metastasis (Metastasis) 08/01/2009 - "Using gain and loss of function experiments, we found that PAK5 reduced CRC cell adhesion but promoted their migration on collagen type I. Taken together, our study demonstrated that PAK5 expression increased significantly with malignant progression of CRC and that PAK5 might promote CRC metastasis by regulating CRC cell adhesion and migration." 05/01/1995 - "[Clinical studies using measurement of N-telopeptides of type 1 collagen (NTx) in patients with bone metastasis--comparison with bone scintigraphy and other metabolic bone markers]." 09/25/2014 - "NTx is a type I collagen metabolite previously shown to be increased in patients with bone metastasis. " 09/01/2011 - "This indicates that the monomeric form reflects the degradation of type I collagen because bone metastases are osteolytic in nature. " 05/01/2009 - "In patients that never developed bone metastases, cross-linked carboxy-terminal telopeptide of type I collagen was increased. "
5.	Systemic Scleroderma (Systemic Sclerosis) 04/01/2006 - "The pleiotropic protective effects of statins on various endothelial and immune cell functions in conjunction with their potent inhibitory effects on type I collagen gene expression suggest that statins may be effective therapeutic agents in systemic sclerosis." 12/01/1994 - "The results of this study suggest that peripheral blood mononuclear cells from patients with systemic sclerosis are specifically sensitized to human type I collagen to produce increased levels of IL-6, which may play a role in the pathogenesis in this fibrotic disorder." 01/01/2013 - "Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts." 08/01/2004 - "Dosage effects of orally administered bovine type I collagen on immune function in patients with systemic sclerosis." 03/01/2004 - "Scleroderma or SSc (systemic sclerosis) is a fibrotic disease characterized by excessive production of extracellular matrix components, especially type I collagen. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Collagen Type I (Type I Collagen)
3.	Collagen
4.	Fibronectins (Fibronectin)
5.	Alkaline Phosphatase
6.	collagen type I trimeric cross-linked peptide
7.	pyridinoline
8.	candesartan cilexetil (Amias)
9.	Collagen Type III (Type III Collagen)
10.	Collagen Type II (Type II Collagen)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Filtering Surgery
4.	Hydrocolloid Bandages (Duoderm)
5.	Lasers (Laser)