Defensins

Family of antimicrobial peptides that have been identified in humans, animals, and plants. They are thought to play a role in host defenses against infections, inflammation, wound repair, and acquired immunity.

Networked: 437 relevant articles (4 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stange, Eduard F: 12 articles (11/2015 - 07/2002)
2.	Wehkamp, Jan: 11 articles (11/2015 - 07/2002)
3.	Lu, Wuyuan: 11 articles (09/2014 - 09/2005)
4.	Smith, Jason G: 7 articles (03/2015 - 01/2008)
5.	Chang, Theresa L: 6 articles (04/2012 - 07/2004)
6.	Ouellette, André J: 5 articles (01/2015 - 11/2010)
7.	Buhimschi, Catalin S: 5 articles (09/2012 - 07/2005)
8.	Buhimschi, Irina A: 5 articles (09/2012 - 07/2005)
9.	Wehkamp, J: 5 articles (06/2009 - 05/2003)
10.	Stange, E F: 5 articles (06/2009 - 05/2003)

Related Diseases

1.	Infection 09/01/2014 - "Our studies support a mechanism in which α-defensins depend on hydrophobic and charge-charge interactions to bind at high copy number to these non-enveloped viruses to neutralize infection and provide insight into properties that guide α-defensin anti-viral activity. " 01/01/2009 - "This review focuses on the interplay between defensins and viral infections, the mechanisms of action of defensins and the in vivo studies of the role of defensins in viral infections." 01/17/2008 - "Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. " 12/15/2006 - "This study examined the ability of nine human defensins (HD) to protect against herpes simplex virus infection. " 09/15/2002 - "To explore the relationship between neutrophil defensins and upper genital tract infection, 377 women who were at risk for PID were enrolled in a study. "
2.	Bacterial Infections (Bacterial Infection) 08/01/2007 - "Defensins are a component of the host response against bacterial infections. " 08/01/2007 - "Defensins in the immunology of bacterial infections." 12/01/1998 - "We have recently demonstrated that radiolabelled human defensins allow the rapid visualization of bacterial infections in mice. " 04/14/2009 - "Defensins are important antimicrobial effector peptides of the innate immune system, which provides protection against bacterial infections in the intestine. " 01/01/2013 - "Human α-defensins are proteins of the innate immune system that suppress viral and bacterial infections by multiple mechanisms including membrane disruption. "
3.	Periodontitis 11/01/2015 - "In controls, hBD-2 was localized at the superficial layers of the gingival epithelium, hBD-3 and hCAP18/LL-37 were at the basal layers, whereas in subjects with periodontitis both defensins were visible at all epithelial layers. " 01/01/2009 - "1. Finding of apoptotic cells are variable and seems to correlate with the expression of defensins in oral epithelium in patients with periodontitis. " 03/01/2005 - "However, by virtue of their cationic nature we postulated that the defensins would fly particularly well in mass spectrometry and that this characteristic would allow facile identification of individual HNPs in unfractionated gingival crevicular fluid (GCF) from periodontitis patients and healthy controls. " 12/01/2003 - "Defensins may be useful for the treatment of periodontal disease and for the prevention of caries and periodontitis." 02/01/2014 - "Although the secretion of antimicrobial peptides in gingival tissue and isolated cells has been reported, the induction of human β-defensins (hBDs) in epithelial cells from the periodontitis patients was not stated before. "
4.	Periodontal Diseases (Periodontal Disease) 10/01/2013 - "The dual effect of IL-1β on hBDs expression may contribute to the defensins down-regulation in periodontal disease." 12/01/2003 - "Defensins may be useful for the treatment of periodontal disease and for the prevention of caries and periodontitis." 04/01/2003 - "Here we show that human neutrophil peptide (HNP) defensins or human beta-defensins (HBD), co-administered intranasally with the antigen ovalbumin (OVA), induce unique immune responses that if used with microbial antigens may have the potential to hinder the pathogenesis of periodontal disease. "
5.	Inflammation 01/01/2015 - "Astrocytes express β-defensins, which can chemoattract and promote maturation of dendritic cells (DC), and can also limit inflammation by controlling the viability of these same DC. " 05/01/2014 - "We conclude that absence of MMP7 protects mice from LPS-induced intestinal permeability and lethality, and suggest that MMP7-activated α-defensins, in addition to their previously recognized bactericidal and anti-inflammatory roles, may exhibit pro-inflammatory activities in the intestine by activating macrophages and amplifying the local inflammatory response in the gut, leading to intestinal leakage and subsequent increase in systemic inflammation. " 11/15/2013 - "In addition to its antimicrobial activity, defensins present other activities such as chemoattraction of a range of different cell types to the sites of inflammation. " 01/01/2013 - "In ileal CD, a strong association can be found between diminished expression or defective function of defensins and the advent of intestinal inflammation." 10/15/2011 - "MK, BRAK/CXCL14, and the inflammation-dependent antimicrobial β-defensins human β-defensin (hBD)-2 and hBD-3 all showed bactericidal activity against both F. "

Related Drugs and Biologics

1.	Peptides
2.	Cathelicidins
3.	Elafin
4.	Proteins (Proteins, Gene)
5.	Messenger RNA (mRNA)
6.	Serine Proteases (Serine Protease)
7.	Antibodies
8.	Biological Markers (Surrogate Marker)
9.	CAP18 lipopolysaccharide-binding protein (Bac4)
10.	Toll-Like Receptors (Toll-Like Receptor)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Laparoscopic Cholecystectomy
3.	Lung Transplantation
4.	Cholecystectomy
5.	Therapeutics