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beta-3 Adrenergic Receptors

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The beta-3 adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.
Also Known As:
Receptors, Adrenergic, beta-3; Adrenergic Receptors, beta-3; Adrenergic beta-3 Receptor; Receptor, Adrenergic beta-3; beta3 Adrenoreceptor; Adrenergic Receptors, beta 3; Adrenergic beta 3 Receptor; Adrenergic beta 3 Receptors; Adrenoreceptor, beta3; Receptor, Adrenergic beta 3; Receptors, Adrenergic beta-3; Receptors, beta 3 Adrenergic; beta 3 Adrenergic Receptors; beta-3 Receptor, Adrenergic; beta-3 Receptors, Adrenergic; Adrenergic beta-3 Receptors; Beta 3 Adrenergic Receptor; Receptors, beta-3 Adrenergic
Networked: 30 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Dong, Jing: 1 article (01/2021)
2. Li, Man-Wen: 1 article (01/2021)
3. Lin, Qian: 1 article (01/2021)
4. Liu, De-Feng: 1 article (01/2021)
5. Ma, Zheng-Ye: 1 article (01/2021)
6. Wang, Hai-Dan: 1 article (01/2021)
7. Zhang, Cai-Shun: 1 article (01/2021)
8. Zhang, Qing: 1 article (01/2021)
9. Keam, Susan J: 1 article (11/2018)
10. Aller, Rocío: 1 article (03/2017)

Related Diseases

1. Insulin Resistance
10/01/1999 - "The physiological role of the adrenergic beta-3 receptor is poorly understood in man but the Trp64Arg mutation of the receptor gene has been related to the insulin resistance syndrome, an earlier onset of diabetes and rapid weight gain. "
12/09/1998 - "To elucidate relationships between the UCPs expressions and insulin sensitivity improvement, we treated KK-Ay mice with beta 3 adrenergic receptor agonist for 21 days and examined the changes of the UCPs mRNA expressions in various tissues. "
05/01/2012 - "The aim of our study was to investigate the interaction of tryptophan-to-arginine (Trp64Arg) missense mutation in the beta3 adrenoreceptor (Beta3AR) with polymorphism in the UCP3 promotor (-55C->T) on insulin resistance in obese patients. "
01/01/2021 - "The literature search was performed in PubMed, Embase, and Web of Science using the keywords "Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3" from 2005 to February 7, 2021. "
01/01/2006 - "Our hypothesis has the following clinical implications: (1) differing responses to weight loss may be seen with regards to insulin resistance depending on the size of the fat depot; individuals with small fat depots having to maintain an extremely low body mass to preserve an insulin sensitive phenotype while individuals with a large fat depot may become insulin sensitive even when still clinically obese with some amount of weight loss; (2) peroxisome proliferator activated receptor gamma agonists, such as thiazoledinediones which expand the subcutaneous fat depot, may be especially useful in improving insulin resistance in individuals with small fat depots; (3) expanding alternate storage sites for triglycerides by a variety of techniques, such as resistance training-induced muscle hypertrophy, may also improve insulin resistance; (4) drugs, such as beta 3 adrenergic receptor agonists which promote lipolysis and have been suggested as possible agents in the treatment of obesity may actually increase insulin resistance by releasing free fatty acids into the circulation. "
2. Weight Loss (Weight Reduction)
01/01/1998 - "While in animal experiments stimulation of beta-3 adrenergic receptors leads to a significant weight loss, in humans these drugs fail to stimulate energy expenditure probably due to the lack of significant amounts of brown adipose tissue. "
12/01/1996 - "To investigate whether the genetic polymorphisms of the uncoupling protein (UCP) and beta 3 adrenergic receptor (beta 3 AR) were associated with differences of weight loss in obese patients submitted to a low calorie diet. "
04/01/2010 - "The purpose of this study was to investigate whether the genetic polymorphisms of the uncoupling protein 1 (UCP1) and beta 3 adrenergic receptor (beta3-AR) were associated with differences in weight loss and lipid profiles in obese premenopausal women exposed to low-calorie meal replacements over a period of six weeks. "
01/01/2006 - "Our hypothesis has the following clinical implications: (1) differing responses to weight loss may be seen with regards to insulin resistance depending on the size of the fat depot; individuals with small fat depots having to maintain an extremely low body mass to preserve an insulin sensitive phenotype while individuals with a large fat depot may become insulin sensitive even when still clinically obese with some amount of weight loss; (2) peroxisome proliferator activated receptor gamma agonists, such as thiazoledinediones which expand the subcutaneous fat depot, may be especially useful in improving insulin resistance in individuals with small fat depots; (3) expanding alternate storage sites for triglycerides by a variety of techniques, such as resistance training-induced muscle hypertrophy, may also improve insulin resistance; (4) drugs, such as beta 3 adrenergic receptor agonists which promote lipolysis and have been suggested as possible agents in the treatment of obesity may actually increase insulin resistance by releasing free fatty acids into the circulation. "
3. Diabetes Mellitus
4. Dyslipidemias (Dyslipidemia)
5. Metabolic Syndrome (Dysmetabolic Syndrome X)

Related Drugs and Biologics

1. Uncoupling Protein 1
2. Tryptophan (L-Tryptophan)
3. Metoprolol (Toprol-XL)
4. Lipids
5. Atenolol (Tenormin)
6. Arginine (L-Arginine)
7. Mitochondrial Uncoupling Proteins
8. PPAR gamma
9. Leptin
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Resistance Training
2. Caloric Restriction
3. Ligation