Virosomes

Semi-synthetic complex derived from nucleic-acid free viral particles. They are essentially reconstituted viral coats, where the infectious nucleocapsid is replaced by a compound of choice. Virosomes retain their fusogenic activity and thus deliver the incorporated compound (antigens, drugs, genes) inside the target cell. They can be used for vaccines (VACCINES, VIROSOME), drug delivery, or gene transfer.

Also Known As:

Networked: 194 relevant articles (14 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zurbriggen, Rinaldo: 27 articles (06/2012 - 06/2002)
2.	Amacker, Mario: 21 articles (01/2022 - 01/2005)
3.	Wilschut, Jan: 16 articles (02/2014 - 02/2002)
4.	Pluschke, Gerd: 15 articles (01/2022 - 08/2003)
5.	Westerfeld, Nicole: 14 articles (12/2011 - 01/2005)
6.	Glück, R: 12 articles (07/2003 - 01/2000)
7.	Huckriede, Anke: 11 articles (04/2018 - 02/2002)
8.	Moser, Christian: 8 articles (01/2017 - 07/2004)
9.	Zurbriggen, R: 8 articles (02/2010 - 01/2000)
10.	Jamali, Abbas: 6 articles (06/2017 - 09/2012)

Related Diseases

1.	Human Influenza (Influenza) 12/01/2014 - "An H1-H3 chimeric influenza virosome confers complete protection against lethal challenge with PR8 (H1N1) and X47 (H3N2) viruses in mice." 08/01/2016 - "Chimeric influenza virosome, including VSV-G, is superior to the conventional influenza virosome for gene delivery." 01/01/2023 - "Influenza-based virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has tolerability profile due to their purity and biocompatibility. " 01/01/2023 - "A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge." 11/01/2021 - "Influenza virosomes were prepared by solubilization of the viral membrane with 1,2-distearoyl-sn-glycerol-3-phosphocholine (DSPC). "
2.	Infections 01/01/2013 - "Finally, IN immunization with adjuvanted virosomes, particularly Pam3CSK4/L18-MDP-adjuvanted-virosomes, protected mice against infection with RSV, without priming for enhanced disease. " 03/01/2010 - "However, even at high multiplicities of infection (10 PFU/cell), we estimate approximately 20% of the virosomes never fuse. " 01/01/2007 - "Interestingly, these same structures, called virus factories, virus inclusions, or virosomes, can recruit host components that are associated with cellular defences against infection and cell stress. " 08/01/2003 - "By confocal microscopy, we observed that CypA went through an intense reorganization in the cell cytoplasm and colocalized with the virosomes late in infection. " 04/01/2000 - "The infection arrests early during viral morphogenesis, with the accumulation of large numbers of vesicles and the appearance of "empty" crescents that appear to adhere only loosely to virosomes. "
3.	Neoplasms (Cancer) 08/01/2023 - "Vaccination with both types of virosomes significantly improved the control of tumor outgrowth, leading to elimination of the tumors in about half the animals for the best combinations of adjuvants and to their survival beyond 100 days." 06/01/2015 - "This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment." 01/01/2020 - "Design of an innovative platform for the treatment of cerebral tumors by means of erythro-magneto-HA-virosomes." 06/01/2015 - "Cancer treatment is a big battlefield for virosome-based drug delivery systems. " 06/01/2015 - "Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment."
4.	Hepatitis A (Hepatitis, Infectious) 12/01/1992 - "Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A." 09/01/2008 - "Two influenza virosomal vaccines - for influenza and hepatitis A - are registered for human use, and the virosome platform is being evaluated as the carrier for a Plasmodium falciparum vaccine that targets both the exo-erythrocytic and erythrocytic stages. " 09/01/2003 - "A single dose of a hepatitis A virosome vaccine is safe and protects young children against HAV infection." 12/01/1999 - "Tolerance and immunogenicity of the simultaneous administration of virosome hepatitis A and yellow fever vaccines." 10/01/1996 - "The anti-PE and anti-PC antibody response was determined for human volunteers immunized with a virosome-formulated vaccine against hepatitis A, or a standard or virosome-formulated influenza vaccine. "
5.	Influenza in Birds (Avian Flu) 06/01/2012 - "Here we examined the protective efficacy of a virosome-based vaccine consisting of avian influenza virus (AIV) A/Duck/Czech/56/H4N6 in chickens against a homologous AIV challenge. " 06/01/2012 - "Vaccination with CpG-adjuvanted avian influenza virosomes promotes antiviral immune responses and reduces virus shedding in chickens." 02/11/2011 - "In this study, we examined the immunogenicity of avian influenza virosomes with or without inclusion of recombinant chicken interferon-gamma (rChIFN-γ) or CpG-ODN in chickens. " 02/11/2011 - "Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN."

Related Drugs and Biologics

1.	Vaccines
2.	Peptides (Polypeptides)
3.	Antigens
4.	Proteins (Proteins, Gene)
5.	Hepatitis A Vaccines (Hepatitis A Vaccine)
6.	E coli heat-labile enterotoxin
7.	Aluminum
8.	Epitopes
9.	DNA Vaccines
10.	Cancer Vaccines

Related Therapies and Procedures

1.	Immunotherapy
2.	Mucosal Administration
3.	Injections
4.	Sublingual Administration
5.	Therapeutics