Subunit Vaccines

Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.

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Networked: 634 relevant articles (83 outcomes, 82 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Itoh, Kyogo: 10 articles (10/2015 - 10/2006)
2.	Noguchi, Masanori: 7 articles (10/2015 - 06/2007)
3.	Yamada, Akira: 6 articles (10/2015 - 06/2005)
4.	Slansky, Jill E: 6 articles (11/2013 - 01/2008)
5.	Celis, Esteban: 5 articles (08/2015 - 04/2002)
6.	Jordan, Kimberly R: 5 articles (11/2013 - 01/2008)
7.	Kaumaya, Pravin T P: 5 articles (07/2013 - 04/2003)
8.	Sin, Jeong-Im: 5 articles (04/2013 - 05/2006)
9.	Sasada, Tetsuro: 4 articles (10/2015 - 01/2013)
10.	Slingluff, Craig L: 4 articles (11/2014 - 04/2006)

Related Diseases

1.	Infection 06/01/2014 - "Overall, this study demonstrates that eliciting CD4 T cell responses against components of the Salmonella type III secretion system can contribute to protection against infection and should be considered in the design of future Salmonella subunit vaccines. " 11/01/2006 - "Recent clinical trials in young women have shown that subunit vaccines based on human papillomavirus (HPV) 16 and HPV18 L1 virus-like particles are approximately 100% effective in short-term prevention of persistent cervical infection and of cervical dysplasia by these major oncogenic types. " 01/01/2015 - "Peptide vaccines have been shown effective in preventing animal infection in some instances, and various formulations are under evaluation for their potential clinical use in humans. " 01/01/1999 - "Synthetic peptide vaccines effective in preventing virus infection." 01/01/2015 - "Recombinant subunit vaccines provide safe and targeted protection against viral infections. "
2.	Neoplasms (Cancer) 08/01/2007 - "Radiation plus E7 subunit vaccines improved complete response, cure, and recurrence rates of tumors dramatically compared with single therapy alone. " 08/01/2014 - "ErbB-2-directed peptide vaccines have been shown to be effective in prevention of spontaneous tumorigenesis of breast in neu transgenic mouse model, and cellular immunity is proposed as a mechanism for the anti-tumor efficacy. " 01/01/2014 - "Novel adjuvants hold the promise for developing effective modern subunit vaccines capable of appropriately modulating the immune response against challenging diseases such as those caused by chronic and/or intracellular pathogens and cancer. " 04/28/2013 - "Peptide vaccines are a clinically applicable therapy shown to be effective in tumor control. " 07/01/2007 - "Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo."
3.	Malaria 03/01/2013 - "Protection against malaria can be achieved by induction of a strong CD8(+) T-cell response against the Plasmodium circumsporozoite protein (CSP), but most subunit vaccines suffer from insufficient memory responses. " 12/01/2002 - "It is widely believed that subunit vaccines composed of multiple components will offer greater protection against challenge by malaria, and yet there is little experimental evidence to support this view. " 12/01/2005 - "However, the limited complexity of malaria peptide vaccines raises questions regarding their equivalence to immune responses elicited by the irradiated sporozoite vaccine, the "gold standard" for protective immunity. " 06/16/2011 - "While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated sporozoites (RAS) remain the "gold standard" for sterilizing protection against Plasmodium infection in human vaccinees. " 01/01/2010 - "Over the past decade (2000-2009), there have been nine clinical trials of synthetic malaria peptide vaccines designed to target the pre-erythrocytic and erythrocytic stages of the Plasmodium falciparum parasite. "
4.	Human Influenza (Influenza) 03/01/2013 - "The increased worldwide awareness of seasonal and pandemic influenza, including pandemic H1N1 virus, has stimulated interest in the development of economic platforms for rapid, large-scale production of safe and effective subunit vaccines. " 01/01/2012 - "These results demonstrate the promising potential of microneedle delivery of licensed influenza subunit vaccines, that could be beneficial in increasing vaccine coverage and protection and reducing influenza-related mortality worldwide." 03/05/1999 - "The aim of this study was to improve the potency of the currently used influenza subunit vaccines, which are of relatively low efficiency in high-risk groups. " 04/01/2015 - "Influenza whole inactivated virus (WIV) is more immunogenic and induces protective antibody responses compared with other formulations, like split virus or subunit vaccines, after intranasal mucosal delivery. " 01/01/2014 - "Recombinant subunit vaccines are an efficient strategy to meet the demands of a possible influenza pandemic, because of rapid and scalable production. "
5.	Tuberculosis (Tuberculoses) 11/01/1995 - "Tuberculosis remains a major public health burden which could be ameliorated by effective and well-defined subunit vaccines, particularly because the protective efficacy of current M. " 01/01/2009 - "tuberculosis, improved recombinant BCG strains and subunit vaccines have been tested in preclinical animal models, and some of them showed promising results. " 11/11/2008 - "Immunogenicity and protective efficacy of tuberculosis subunit vaccines expressing PPE44 (Rv2770c)." 05/01/2014 - "In order to ensure an ample supply of quality candidate tuberculosis (TB) subunit vaccines for clinical trials, it is imperative to develop new immunostimulatory adjuvants. " 06/01/2009 - "These studies have major implications for the design of sulfoglycolipid analogs with potential use as tuberculosis subunit vaccines."

Related Drugs and Biologics

1.	Antigens
2.	DNA (Deoxyribonucleic Acid)
3.	Peptides
4.	Glycoproteins (Glycoprotein)
5.	Vaccines
6.	Antibodies
7.	Recombinant DNA (Recombinant DNA Research)
8.	Epitopes
9.	Proteins (Proteins, Gene)
10.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

Related Therapies and Procedures

1.	Immunotherapy
2.	Drug Therapy (Chemotherapy)
3.	Microspheres (Microsphere)
4.	Castration
5.	Therapeutics