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Tacrolimus Binding Proteins (FKBP)

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A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-

Also Known As:

FKBP; FK-506-Binding Protein; FK506-Binding Protein; FKBP Rotamase; Rapamycin-Binding Proteins; Binding Proteins, Rapamycin; FK 506 Binding Protein; Protein, FK-506-Binding; Protein, FK506-Binding; Proteins, Rapamycin-Binding; Rotamase, FKBP; FK506 Binding Protein; FK506 Binding Proteins; Rapamycin Binding Proteins

Networked: 141 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Robson, Tracy: 3 articles (05/2015 - 01/2010)
2.	Lai, F Anthony: 3 articles (10/2013 - 02/2005)
3.	Romano, S: 3 articles (01/2013 - 01/2010)
4.	Romano, M F: 3 articles (01/2013 - 01/2010)
5.	Yoon, Ho Sup: 3 articles (01/2013 - 01/2008)
6.	Dai, De-Zai: 3 articles (01/2010 - 03/2005)
7.	Li, Song: 3 articles (08/2006 - 09/2002)
8.	McKeen, Hayley D: 2 articles (05/2015 - 07/2013)
9.	McClements, Lana: 2 articles (05/2015 - 07/2013)
10.	Yakkundi, Anita: 2 articles (05/2015 - 07/2013)

Related Diseases

1.	Heart Failure 01/17/2014 - "In heart failure, RyR2 shows decreased CaM affinity, but unaltered FKBP 12.6 affinity." 08/01/2005 - "The hyperadrenergic state of heart failure results in leaky RyR(2) channels attributable to PKA hyperphosphorylation and depletion of the stabilizing FK506 binding protein, FKBP12.6. Dysregulation of sarcoplasmic reticulum (SR) Ca(2+) release via RyR(2) could contribute to defects in Ca(2+) signaling in failing hearts. " 05/20/2003 - "The hyperadrenergic state of heart failure results in leaky RyR2 channels attributable to PKA hyperphosphorylation and depletion of the stabilizing FK506 binding protein, FKBP12.6. We tested the hypothesis that improved cardiac muscle function attributable to beta-AR blockade is associated with restoration of normal RyR2 channel function in patients with heart failure. " 11/01/2000 - "We assessed whether the alteration in this function in heart failure is related to a change in the role of FK binding protein (FKBP), which is tightly coupled with the cardiac ryanodine receptor (RyR) and recently identified as a modulatory protein acting to stabilize the gating function of RyR. " 10/24/2000 - "Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506-binding protein (FKBP12.6) with the cardiac ryanodine receptor (RyR) in a canine model of pacing-induced heart failure. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2002 - "Our studies also show for the first time that the immunophilin FKBP is present in the human brain and that its levels are altered in the brain of patients with neurodegenerative diseases. " 01/01/2011 - "Role of FK506 binding proteins in neurodegenerative disorders." 09/01/2002 - "[FK506-binding proteins and neurodegenerative diseases]." 07/13/2006 - "This study further suggests the clinical potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson's disease." 12/01/2006 - "Meridamycin is a non-immunosuppressant, FKBP-binding macrocyclic polyketide, which has major potential as a neuroprotectant in a range of neurodegenerative disorders including dementia, Parkinson's disease and ischaemic stroke. "
3.	Neoplasms (Cancer) 05/20/2015 - "FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. " 07/15/2013 - "FK506-binding protein like (FKBPL) and its peptide derivative, AD-01, have already shown tumor growth inhibition and CD44-dependent antiangiogenic activity. " 08/01/2011 - "Accumulating evidence has implicated some FKBP members in a variety of processes, such as the cell cycle and survival and apoptotic signaling pathways, particularly in cancers. " 01/01/2011 - "The emerging role of large immunophilin FK506 binding protein 51 in cancer." 08/01/2011 - "After the deregulation of their expression was observed in cancer tissues, it became increasingly clear that FKBP members played an important role in tumorigenesis and the response to chemotherapies and radiotherapies and that FKBP members could act as oncogenes or tumor suppressors depending on the tissue type. "
4.	Infection 03/15/2014 - "In this study, we investigated three immunophilin genes involved in the Arabidopsis thaliana response to Pseudomonas syringae infection: a cytoplasmic localized AtCYP19, a cytoplasmic and nuclear localized AtCYP57, and one nucleus directed FKBP known as AtFKBP65. " 10/01/2012 - "Likewise, a conserved FKBP family protein has also been identified in Aedes aegypti (AaFKBP12), which is expected to play a similar role in the life cycle of Aedes aegypti, the primary vector of dengue virus infection. " 08/01/2002 - "FK520, an immunosuppressor which binds to FKBP, had no effect on HIV-1 infection." 09/01/2013 - "FK506-binding protein orthologs have been described as conserved host resistance factors, which suppress dengue and West Nile virus infection in human HeLa cells. " 11/01/2013 - "To establish the role of both domains in tularaemia infection models, site-directed and deletion mutagenesis affecting the active site (AXXA), the cis-proline (P286T) and the FKBP_N domain (ΔFKBP_N) were performed. "
5.	Parkinson Disease (Parkinson's Disease) 02/17/2010 - "Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology." 07/13/2006 - "This study further suggests the clinical potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson's disease." 12/01/2006 - "Meridamycin is a non-immunosuppressant, FKBP-binding macrocyclic polyketide, which has major potential as a neuroprotectant in a range of neurodegenerative disorders including dementia, Parkinson's disease and ischaemic stroke. " 02/14/2013 - "Members of this family, and notably FK506 binding protein (FKBP12), are thought to be involved in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis, as well as in proliferation disorders and cancer. " 11/01/2001 - "Alzheimer's disease, Parkinson's disease, diabetic neuropathy) a number of different approaches were pursued to obtain selectively acting FK506-binding protein (FKBP) ligands: computational methods and target-oriented screening of natural compound and synthetic product libraries. "

Related Drugs and Biologics

1.	tacrolimus binding protein 1B
2.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
3.	Protein Kinase C-epsilon
4.	NADPH Oxidase (NAD(P)H oxidase)
5.	Isoproterenol (Isoprenaline)
6.	1- (methanesulfonamido- 1- naphthyloxy)- 2- (N- (4- methane sulfonamidophenethyl)-N-acetamido)ethane
7.	dofetilide (Tikosyn)
8.	Glucocorticoid Receptors (Glucocorticoid Receptor)
9.	Ligands
10.	Sirolimus (Rapamycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Atherectomy
3.	Stents
4.	Therapeutics
5.	Radiotherapy