Cyclophilins (Cyclophilin)

10/01/2015 - "Cyclophilin polymorphism and virus infection."
02/19/2015 - "Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection."
01/01/2015 - "The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of Action."
08/01/2014 - "We found that cyclophilin inhibitors reduce phosphorylation of PKR and eIF2α during HCV infection to allow for translation of ISG products. "
08/01/2014 - "Cyclophilin inhibitors are being developed for treatment of hepatitis C virus (HCV) infection. "

02/01/2013 - "Cyclophilin inhibitors for hepatitis C therapy."
03/01/2011 - "The use of oral cyclophilin inhibitors as part of a combination regime for treatment of hepatitis C, especially to deter resistance, holds promise."
05/01/2009 - "The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients."
10/23/2014 - "Nonimmunosuppressive cyclophilin inhibitors have demonstrated efficacy for the treatment of hepatitis C infection (HCV). "
09/01/2007 - "Cyclophilin inhibitors in hepatitis C viral infection."

10/01/2012 - "Alisporivir is the most advanced host-targeting antiviral cyclophilin (Cyp) inhibitor in phase III studies and has demonstrated a great deal of promise in decreasing hepatitis C virus (HCV) viremia in infected patients. "

04/01/1990 - "However, the similar cyclophilin content of normal and diseased tissue suggests that differences in cyclosporine uptake probably do not account for its therapeutic efficacy in psoriasis."

03/01/2006 - "Given that extracellular cyclophilins are potent chemotactic agents for various immune cells, further studies of the role of cyclophilin-CD147 interaction in inflammation followed. "
10/01/2015 - "Extracellular cyclophilins present an attractive target for therapeutic interventions that can be used to alleviate symptoms and consequences of acute and chronic inflammation. "
09/01/2007 - "Cyclophilins are secreted by a variety of cell types and are detected at high levels in tissues with ongoing inflammation. "
07/01/2005 - "These findings are the first to demonstrate the significant contribution of cyclophilins to inflammatory responses and provide a potentially novel approach for reducing inflammation-mediated diseases."
01/01/2013 - "Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. "