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Protein Sorting Signals (Signal Peptide)

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Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.

Also Known As:

Signal Peptide; Signal Sequence; Leader Peptide; Peptide, Signal; Leader Sequences, Peptide; Peptide Leader Sequences; Peptide Signal Sequences; Signal Peptides; Signal Sequence, Peptide; Signal Sequences; Signal Sequences, Peptide; Leader Peptides; Leader Sequence, Peptide; Leader Signal Peptide; Peptide Leader Sequence; Peptide Signal Sequence; Peptide, Leader; Peptide, Leader Signal; Peptides, Leader; Peptides, Leader Signal; Peptides, Signal; Protein Sorting Signal; Sequence, Peptide Leader; Sequence, Peptide Signal; Sequence, Signal; Sequences, Peptide Leader; Sequences, Peptide Signal; Sequences, Signal; Signal Peptide, Leader; Signal Peptides, Leader; Signal, Protein Sorting; Signals, Protein Sorting; Sorting Signal, Protein; Sorting Signals, Protein; Leader Signal Peptides

Networked: 852 relevant articles (12 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Song, Linsheng: 11 articles (05/2012 - 02/2007)
2.	Qiu, Limei: 9 articles (05/2012 - 05/2008)
3.	Wang, Lingling: 9 articles (05/2012 - 05/2008)
4.	Zhao, Jianmin: 9 articles (05/2012 - 02/2007)
5.	Zhang, Huan: 9 articles (05/2012 - 01/2008)
6.	Pemberton, Chris J: 6 articles (12/2015 - 07/2010)
7.	Mentese, Ahmet: 6 articles (09/2015 - 01/2012)
8.	Pesonen, Ullamari: 6 articles (03/2007 - 05/2003)
9.	Koulu, Markku: 5 articles (03/2007 - 07/2003)
10.	Sun, Xiaofen: 5 articles (03/2007 - 06/2004)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2011 - "For the present study, we designed lentivirus-mediated signal peptide TNF-α-Tumstatin(45-132) -expressing mesenchymal stem cells (SPTT-MSCs) as a novel anti-cancer approach. " 06/21/2008 - "In this study, we designed a secretory protein by adding a secretory signal peptide (SP) to the N terminus of Transactivating Transcription (TAT)-apoptin (SP-TAT-apoptin), to test the hypothesis that it gains an additive bystander effect as an anti-cancer therapy. " 09/01/2003 - "In the present study, we investigated the feasibility of modifying a cytokine signal peptide with a tumor antigenic epitope. " 07/01/2015 - "Additionally, the analysis of the PRL transcripts in lung tumors and cell lines revealed systematic truncations of their 5' regions, including the signal peptide-encoding portions. " 10/01/2014 - "Using a B2 deletion mutant, the B2 mitochondrial targeting signal sequence ((41)RTFVISAHAA(50)) correlated with mitochondrial free radical production and cell death in fish cells, embryonic zebrafish, and human cancer cells. "
2.	Melanoma (Melanoma, Malignant) 04/01/2013 - "Similarly, WM-266-4 melanoma cells that express endogenous hUcn 2 secreted only the glycosylated prohormone lacking the signal peptide and unmodified at the C terminus. " 02/21/2007 - "KISS1 containing an internal FLAG epitope with (KFM) or without (KFMdeltaSS) a signal sequence was transfected into C8161.9 human melanoma cells, which do not express endogenous KISS1. " 03/02/2000 - "The high basal activity of the mda-7 promoter in uninduced melanoma cells and the absence of enhancing effect upon treatment with differentiation inducers is corroborated by transfection studies using the promoter region of mda-7 linked to a luciferase reporter gene containing the SV40 polyadenylation signal sequence. " 08/01/2000 - "We report here that the addition of synthetic signal sequences at the N terminus, but not at the C terminus, of an epitope from the human melanoma antigen MART-1 greatly enhances its presentation in both TAP-deficient and TAP-expressing cells. " 08/01/2000 - "Synthetic insertion signal sequences enhance MHC class I presentation of a peptide from the melanoma antigen MART-1."
3.	Infection 04/01/2015 - "The C-terminal signal sequence facilitates secretion of SidJ into host cells at early points of infection, whereas the internal signal sequence mediates secretion at later time points. " 04/10/2014 - "White spot syndrome virus VP14 contains transmembrane and signal peptides domain, which is considered to be important for virus infection. " 01/01/2014 - "Here we review how the signal sequence of the GPI-anchor matters in PrP(C) localization, how an altered cellular localization of PrP(C) or differences in GPI-anchor composition can affect prion infection, and we discuss through which mechanisms changes on the anchorage of PrP(C) can modify the disease process." 12/01/2011 - "Finally, overexpression of the Vfr secretion signal sequence significantly decreased speB transcript level and attenuated GAS virulence in two mouse models of invasive infection. " 02/01/2011 - "The analysis of genes differentially expressed during infection revealed a significant enrichment of genes encoding expanded domains as well as signal peptides linking a substantial part of these genes to pathogenicity. "
4.	Malaria 01/01/2011 - "PvRON2 is a 2,204 residue-long protein encoded by a single 6,615 bp exon containing a hydrophobic signal sequence towards the amino-terminus, a transmembrane domain towards the carboxy-terminus and two coiled coil α-helical motifs; these are characteristic features of several previously described vaccine candidates against malaria. " 02/21/2003 - "The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites." 02/09/2007 - "Previous studies have shown that the immunogenicity of rodent malaria parasite-derived circumsporozoite protein (CS) can be improved by deleting the glycosyl-phosphatidyl-inositol (GPI) signal sequence. " 10/01/2006 - "Similar to other oomycete avirulence proteins, AVR3aKI carries a signal peptide followed by a conserved motif centered on the consensus RXLR sequence that is functionally similar to a host cell-targeting signal of malaria parasites. " 04/01/2004 - "A gene encoding a 352 amino acid protein with a putative signal sequence, transmembrane domain and thrombospondin structural homology repeat was identified in the genome of the human malaria parasite, Plasmodium falciparum and the rodent malaria parasite, Plasmodium berghei. "
5.	Dehydration (Water Stress) 12/01/2006 - "The extent of NisB-mediated dehydration could be improved by raising the intracellular concentration NisB or by modulating the export efficiency through altering the signal sequence. " 10/04/2011 - "On the other hand, studies showed that the C-terminal part of the leader peptide serves as a spacer between the binding site and active sites for phosphorylation and elimination, thus restricting the number of hydroxy amino acid side chains that could undergo dehydration. " 11/05/2012 - "Notably, by expressing the leader peptide in trans together with the leaderless prenisin, we were able to increase the dehydration/cyclization efficiency of both NisB and NisC, but still with limited efficiency until the fifth dehydratable residue (Thr13) was processed, thereby enabling three rings to form. " 01/01/2011 - "Reducing the leader peptide to MSTKDFNLDLR led to 3- or 4-fold dehydration. " 07/15/2008 - "However, introduction of Pro residues into the leader peptide strongly affected the efficiency of dehydration, consistent with recognition of the secondary structure of the leader peptide by the synthetase. "

Related Drugs and Biologics

1.	Antigens
2.	Epitopes
3.	DNA (Deoxyribonucleic Acid)
4.	Messenger RNA (mRNA)
5.	A-Form DNA (A-DNA)
6.	Histocompatibility Antigens Class I
7.	Phosphatidylinositols (Phosphatidylinositol)
8.	Proline (L-Proline)
9.	Tissue Plasminogen Activator (Alteplase)
10.	Interleukin-12 (IL 12)

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Transplantation (Transplant Recipients)
3.	Immunomodulation
4.	Bioreactors
5.	Heterologous Transplantation (Xenotransplantation)