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Nut Hypersensitivity (Nut Allergy)

Subscribe to New Research on Nut Hypersensitivity

Allergic reaction to tree nuts that is triggered by the immune system.

Also Known As:

Nut Allergy; Allergy, Nut; Tree Nut Allergy; Allergies, Nut; Allergies, Tree Nut; Allergy, Tree Nut; Hypersensitivities, Nut; Hypersensitivities, Tree Nut; Hypersensitivity, Tree Nut; Nut Allergies; Nut Hypersensitivities; Nut Hypersensitivities, Tree; Nut Hypersensitivity, Tree; Tree Nut Allergies; Tree Nut Hypersensitivities; Hypersensitivity, Nut; Tree Nut Hypersensitivity

Networked: 47 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Immune System Diseases: 2064
- Hypersensitivity: 49123
  - Immediate Hypersensitivity: 1523
    - Food Hypersensitivity: 2796
      - Nut Hypersensitivity: 47

Related Diseases

1.	Hypersensitivity (Allergy)
2.	Anaphylaxis (Anaphylactic Shock)
3.	Food Hypersensitivity (Food Allergy)
4.	Peanut Hypersensitivity (Peanut Allergy)
5.	Seasonal Allergic Rhinitis (Hay Fever)

Experts

1.	Gangur, Venu: 2 articles (05/2015 - 01/2009)
2.	Parvataneni, Sitaram: 2 articles (05/2015 - 01/2009)
3.	Gonipeta, Babu: 2 articles (05/2015 - 01/2009)
4.	Sathe, Shridhar K: 2 articles (03/2014 - 01/2003)
5.	Roux, Kenneth H: 2 articles (03/2014 - 01/2003)
6.	Yu, Grace: 2 articles (06/2012 - 01/2011)
7.	Galli, Stephen J: 2 articles (06/2012 - 01/2011)
8.	Nadeau, Kari C: 2 articles (06/2012 - 01/2011)
9.	Herzenberg, Leonore A: 2 articles (06/2012 - 01/2011)
10.	Reshamwala, Neha: 2 articles (06/2012 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nut Hypersensitivity:

1.	Immunoglobulin E (IgE)IBA 05/01/2015 - "The gold standard for the diagnosis of tree nut allergy is the double-blind, placebo-controlled, oral food challenge; however, simpler and more cost-effective diagnostic methods, such as the skin prick test and serum-specific IgE are often used as a supplement for diagnosis. " 09/01/2015 - "Challenge-confirmed IgE-mediated tree nut allergy prevalence was less than 2 % (although only seven studies used this gold standard) while probable tree nut allergy prevalence ranged from 0.05 to 4.9 %. " 09/01/1999 - "This study includes all patients referred to our laboratory for nut allergy testing from January 1994 to August 1998 who were tested for peanut, hazelnut and brazil nut, and had specific IgE to at least one of these nuts. " 12/01/2012 - "We studied five children with pine nut allergies and no other sensitization to food except to pine nuts, confirmed by in vivo (prick test, prick-to-prick) and in vitro tests (specific IgE determinations [CAP-FEIA]). " 09/01/2010 - "Resolution of peanut or tree nut allergy cannot be determined conclusively by either allergen-specific IgE analysis or by skin prick testing. "
2.	Epinephrine (Adrenaline)FDA LinkGeneric 01/13/2001 - "Severity of nut allergy was graded 1-5 and emergency medication allocated accordingly: oral antihistamine with or without inhaled or injected epinephrine. " 08/01/2005 - "This study found significant racial, ethnic, and socioeconomic differences in the prevalence of childhood allergic disorders, especially peanut or tree nut allergy, requiring prescribed injectable epinephrine in a school setting. " 08/01/2005 - "Most students (75%) dispensed injectable epinephrine for peanut or tree nut allergy were enrolled in prekindergarten through grade 5 (P < .001). " 08/01/2005 - "Whites were nearly 5 times more likely to be dispensed injectable epinephrine for peanut or tree nut allergy than nonwhites (OR, 4.5; P < .001). " 08/01/2005 - "A total of 181 students in all 3 districts were dispensed injectable epinephrine; 118 of these children had peanut or tree nut allergy. "
3.	CytokinesIBA 01/01/2009 - "These data demonstrate that (i) transdermal exposure to cashew nut protein elicits a robust IgE response leading to clinical sensitization of mice for systemic anaphylaxis to oral cashew nut challenge; (ii) cashew nut is a potent activator of type-2 cytokines, thus explaining the mechanism of cashew allergy, and (iii) this mouse model may be useful for further basic and preclinical studies on cashew nut allergy."
4.	AllergensIBA 01/01/2013 - "Food labelling is an important tool that assists people with peanut and tree nut allergies to avoid allergens. " 12/01/2012 - "Pine nut allergy: clinical features and major allergens characterization." 02/01/2011 - "For individuals with a nut allergy, the avoidance of allergens is particularly challenging in situations where they are not preparing their own food. " 07/01/2006 - "Although poppy seeds are not commonly used, we underline the possible importance of such rare and often hidden sources of allergens, especially in patients with nut allergy." 04/01/2002 - "Pollen, dairy and nut allergies were significantly less common in cases than controls and most other allergens had odds ratios of less than one. "
5.	Proteins (Proteins, Gene)IBA 01/01/2014 - "Proteins responsible for nut allergies." 05/01/2015 - "Alternative therapeutic methods, such as oral and sublingual immunotherapy and modification of allergenic proteins are being explored to develop safer, more effective and long-lasting management of tree nut allergy. "
6.	Carbon MonoxideIBA 12/01/2011 - "Children with tree nut allergy were at risk of co-existing peanut or other tree nut allergy whether PTs were positive or negative. " 01/01/2003 - "Many patients with severe tree nut allergy are co-sensitized to peanut. " 12/01/2011 - "Children allergic to peanuts with negative allergy tests to tree nuts had no co-existing allergy, but were at risk of tree nut allergy where PTs were positive. "
7.	AntibodiesIBA 04/01/1976 - "Serums were obtained from 18 patients with a history of nut allergy and IgE level and specific IgE antibodies were measured. " 08/01/2005 - "Peanut-specific IgE antibodies that cross-react with tree nut allergens can cause effector-cell activation and may contribute to the manifestation of tree nut allergy in peanut allergic subjects." 04/01/1976 - "These results indicate that specific IgE antibodies can be measured by RAST in patients with nut allergy and the cross-reactivity of nut antigens can be investigated. "
8.	HLA-DRB1 antigen (HLA DRB1)IBA 05/01/2004 - "However, the difference in frequency of HLA-DRB1()11 between the nut allergy patients and the atopic controls merits further investigation as this may represent an important phenotypic relationship." 04/01/1998 - "This was found in the case of birch pollen associated hazel nut allergy for the extended haplotype HLA-DRB101, -DQA10101, -DQB10501 as well as in grass pollen associated peanut allergy for HLA-DRB108 (from RR=6, P=0.0013 to insignificant) and in birch pollen associated carrot allergy for HLA-DRB112 (from RR=13, P < 0.000001 to insignificant). " 05/01/2004 - "Eighty-four patients presenting at the allergy clinic with symptoms of nut allergy were typed for the HLA Class I (HLA-A and B) and Class II (HLA-DRB1 and DQB1) loci by PCR using sequence-specific primers. "
9.	Profilins (Profilin)IBA 12/01/1992 - "In contrast, only four sera (22%) from 18 patients (group II) with tree pollen allergy but without any case history of nut hypersensitivity showed IgE binding to the 18 kd protein of hazelnut extract, and none of these sera exhibited IgE reactivity to the hazelnut profilin. "
10.	Eukaryotic Initiation Factor-4EIBA 06/01/2012 - "In this pilot study, we quantified two key mTOR effector phosphoproteins, the eukaryotic initiation factor 4E (peIF4E) and S6 ribosomal protein (pS6rp), in blood basophils from nut allergy patients (NA, N = 16) and healthy controls (HC, N = 13). "

Therapies and Procedures

1.	Immunotherapy 01/01/2011 - "Further studies are needed to determine which single-tree nut immunotherapies will be most effective for specific multi-tree nut allergy profiles." 04/01/2015 - "Oral immunotherapy initiation for multi-nut allergy: a case report." 01/01/2013 - "This observation may open possibilities for developing immunotherapy for Brazil nut allergy. " 05/01/2015 - "Alternative therapeutic methods, such as oral and sublingual immunotherapy and modification of allergenic proteins are being explored to develop safer, more effective and long-lasting management of tree nut allergy. "
2.	Injections 02/01/2002 - "Depot injections and nut allergy." 08/01/2005 - "This study found significant racial, ethnic, and socioeconomic differences in the prevalence of childhood allergic disorders, especially peanut or tree nut allergy, requiring prescribed injectable epinephrine in a school setting. " 08/01/2005 - "Most students (75%) dispensed injectable epinephrine for peanut or tree nut allergy were enrolled in prekindergarten through grade 5 (P < .001). " 08/01/2005 - "Whites were nearly 5 times more likely to be dispensed injectable epinephrine for peanut or tree nut allergy than nonwhites (OR, 4.5; P < .001). " 08/01/2005 - "A total of 181 students in all 3 districts were dispensed injectable epinephrine; 118 of these children had peanut or tree nut allergy. "
3.	Liver Transplantation 01/27/2003 - "Passive transfer of nut allergy after liver transplantation."
4.	Day Care (Partial Hospitalization) 04/01/2001 - "The US Peanut and Tree Nut Allergy Registry: characteristics of reactions in schools and day care." 04/01/2001 - "Participants in the US Peanut and Tree Nut Allergy Registry (PAR) who indicated that their child experienced an allergic reaction in school or day care were randomly selected for a telephone interview conducted with a structured questionnaire. "