HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Chronobiology Disorders (Circadian Rhythm Disorder)

Subscribe to New Research on Chronobiology Disorders

Disruptions of the rhythmic cycle of bodily functions or activities.

Also Known As:

Circadian Rhythm Disorder; Biological Clock Disturbances; Circadian Dysregulation; Inversion of Circadian Rhythm, Psychogenic; Psychogenic Inversion of Circadian Rhythm; Biological Clock Disturbance; Chronobiology Disorder; Disturbance, Biological Clock; Disturbances, Biological Clock; Dysregulation, Circadian; Circadian Rhythm Disorders

Networked: 71 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 6158
- Chronobiology Disorders: 71

Related Diseases

1.	Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)
2.	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)
3.	Fatigue
4.	Lung Injury
5.	Sleep Initiation and Maintenance Disorders (Insomnia)

Experts

1.	Aziz, N Ahmad: 2 articles (01/2013 - 12/2009)
2.	Swaab, Dick F: 2 articles (01/2013 - 09/2007)
3.	Roos, Raymund A C: 2 articles (01/2013 - 12/2009)
4.	Reid, Kathryn J: 2 articles (10/2012 - 06/2005)
5.	Shibata, Shigenobu: 2 articles (03/2012 - 10/2005)
6.	Arendt, Josephine: 2 articles (09/2006 - 01/2006)
7.	Reyes, María P: 2 articles (05/2006 - 12/2005)
8.	Cardinali, Daniel P: 2 articles (05/2006 - 12/2005)
9.	Furio, Analía M: 2 articles (05/2006 - 12/2005)
10.	Ohdo, Shigehiro: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronobiology Disorders:

1.	MelatoninIBA 12/01/2008 - "An indicator of circulating melatonin level has been shown to be a good biomarker of circadian dysregulation and has been associated with nightshift work and exposure to light-at-night in both laboratory-based and field studies. " 12/01/2008 - "Melatonin as a biomarker of circadian dysregulation." 01/01/2006 - "Exogenous melatonin acts as a 'chronobiotic.' Acutely, it increases sleep propensity during 'biological day.' These properties have led to successful treatments for serveal circadian rhythm disorders. " 12/01/2005 - "Treatment of circadian rhythm disorders has led to the development of a new type of agent called "chronobiotics," among which melatonin is the prototype. " 06/01/2005 - "Currently, the management of circadian rhythm disorders is limited to the use of bright light and melatonin to realign the circadian clock with the desired sleep time.However"
2.	Proteins (Proteins, Gene)IBA 11/01/2015 - "In this review, we describe the relationships between the circadian control system and its related genes or proteins, and circadian rhythm disorders in systems biology studies. "
3.	S 20098 (agomelatine)IBA 11/01/2012 - " this study, the antidepressant effects, improvement of circadian rhythm disorders and good tolerability of agomelatine were observed in unselected depressed patients, including multimorbid elderly and severely depressed patients under routine practice."
4.	resveratrolIBA 02/27/2015 - "Resveratrol could improve metabolic disorder, but few reports focused on its effects on circadian rhythm disorders in a variety of studies. "
5.	Serotonin (5 Hydroxytryptamine)IBA 08/01/2005 - "In view of, e.g., the purported involvement of the 5-HT7 receptor in the regulation of circadian rhythm, it may be concluded that the decrease in affinity of 5-HT and other 5-HT receptor agonists at the (Thr92Lys) h5-HT7 receptor may be associated with changes of sleep physiology and of actions of new 5-HT7 receptor agonists designed to treat circadian dysregulation." 10/01/1989 - "Future research on the action of melatonin and serotonin and the photochemical effect of light in relation to possible circadian rhythm disorders should help us to better understand and treat not only SAD but other conditions such as jet lag, premenstrual syndrome, eating disorder, and carbohydrate-craving obesity." 03/01/2015 - "The drugs covered target GABAA (zaleplon-CR, lorediplon, EVT-201), orexin (filorexant, MIN-202), histamine-H1 (LY2624803), serotonin 5-HT2A (ITI-007), melatonin/serotonin5-HT1A (piromelatine) and melatonin (indication expansions of prolonged-release melatonin and tasimelteon for pediatric sleep and circadian rhythm disorders) receptors. "
6.	Hypnotics and Sedatives (Sedatives)IBA 09/01/2011 - "Circadian rhythm disorders, in which an underlying misalignment of circadian rhythm with the sleep-wake cycle occurs, may be treated by behavioral and pharmacologic approaches, including the use of hypnotics to improve the duration of sleep. " 06/01/2002 - "Napping predicts responsiveness to hypnotics in patients with primary circadian rhythm disorder."
7.	Hydrocortisone (Cortisol)FDA LinkGeneric 01/01/2013 - "Sleep and skin disorders interface at several levels: (1) the role of the skin in normal sleep physiology, such as thermoregulation, core body temperature control, and sleep onset; (2) the effect of endogenous circadian rhythms and peripheral circadian "oscillators" on cutaneous symptoms, such as the natural trough in cortisol levels during the evening in patients with inflammatory dermatoses, which most likely results in increased pruritus during the evening and night; (3) the effect of symptoms such as pruritus, hyperhidrosis, and problems with thermoregulation, on sleep and sleep-related quality of life of the patients and their families; (4) the possible effect of primary sleep disorders, such as insomnia, sleep apnea, sleep deprivation, and circadian rhythm disorders, on dermatologic disorders; for example, central nervous system arousals from sleep in sleep apnea can result in increased sympathetic neural activity and increased inflammation; and (5) comorbidity of some dermatologic disorders with stress and psychiatric disorders, for example, major depressive disorder and attention deficit hyperactivity disorder (ADHD) that are also associated with sleep-related complaints. " 06/01/1999 - "This was assessed by investigating the relationship between the cortisol rhythms and the previously determined melatonin rhythms from a large sample of blind people with different types of circadian rhythm disorders. "
8.	HormonesIBA 08/01/2001 - "Melatonin is a pineal hormone that regulates seasonal reproduction and has been used to treat circadian rhythm disorders. " 08/01/1998 - "The pineal hormone melatonin has been proposed as a potential treatment for insomnia and circadian rhythm disorders, as experienced by shiftworkers and transmeridian travellers. "
9.	Carbon MonoxideIBA 10/01/2012 - "High co-morbidity for psychiatric disorders has been observed in patients with circadian rhythm disorders, such as delayed sleep phase disorder (DSPD), and in those with an evening-type circadian preference. " 01/01/2015 - "The categories of sleep disturbances that contribute to obesity and its glycemic co-morbidities include the following: (1) alterations of sleep duration, chronic sleep restriction and excessive sleep; (2) alterations in sleep architecture; (3) sleep fragmentation; (4) circadian rhythm disorders and disruption (i.e., shift work); and (5) obstructive sleep apnea. "
10.	tasimelteonIBA 12/01/2014 - "Mechanism of action of tasimelteon in non-24 sleep-wake syndrome: treatment for a circadian rhythm disorder in blind patients." 03/01/2015 - "The drugs covered target GABAA (zaleplon-CR, lorediplon, EVT-201), orexin (filorexant, MIN-202), histamine-H1 (LY2624803), serotonin 5-HT2A (ITI-007), melatonin/serotonin5-HT1A (piromelatine) and melatonin (indication expansions of prolonged-release melatonin and tasimelteon for pediatric sleep and circadian rhythm disorders) receptors. "

Therapies and Procedures

1.	Phototherapy (Light Therapy) 05/01/2012 - "The short-term side effects of phototherapy include interference with maternal-infant interaction, imbalance of thermal environment and water loss, electrolyte disturbance, bronze baby syndrome and circadian rhythm disorder. " 12/01/2003 - "Common circadian rhythm disorders are described in conjunction with interventions, including chronotherapy and light therapy. " 10/01/2012 - "Light therapy may be beneficial in patients suffering from circadian rhythm disorders such as advanced sleep phase syndrome." 11/01/2002 - "We aimed to determine whether CFS symptoms were alleviated by melatonin and bright-light phototherapy, which have been shown to improve circadian rhythm disorders and fatigue in jet-lag and shift workers. " 11/01/2002 - "Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy."
2.	Artificial Respiration (Mechanical Ventilation) 02/01/2014 - "A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury."
3.	Chronotherapy 12/01/2003 - "Common circadian rhythm disorders are described in conjunction with interventions, including chronotherapy and light therapy. " 01/01/2007 - "However, chronobiology disorders missed 97.6% of its pertinent articles; periodicity, 95.2%; chronobiology, 87.7%; chronotherapy, 70%; time factors, 62.3%; and sleep disorders/circadian rhythm, 47.4%. "
4.	Drug Chronotherapy 01/01/2007 - "The following descriptors were analyzed among the headings of obvious chronobiologic relevance: chronobiology, chronobiology disorders, biological clocks, circadian rhythm, chronotherapy, drug administration schedule, periodicity, seasons, sleep disorders/circadian rhythm, and time factors. "
5.	Continuous Positive Airway Pressure 11/01/2008 - "To review the literature on these important associations, we conducted a PubMed search using combinations of the following terms: sleep disorders, sleep apnea, circadian rhythm disorder, continuous positive airway pressure, eye disease, floppy eyelid syndrome, glaucoma, ischemic optic neuropathy, papilledema, nocturnal lagophthalmos, and vision loss. "