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Embryo Loss

Early pregnancy loss during the EMBRYO, MAMMALIAN stage of development. In the human, this period comprises the second through eighth week after fertilization.
Also Known As:
Disintegration of Blastocyst; Disintegration of Embryo; Death, Embryo; Disintegration, Blastocyst; Embryo Deaths; Resorption, Embryo; Blastocyst Disintegration; Embryo Death; Embryo Disintegration; Embryo Resorption
Networked: 240 relevant articles (8 outcomes, 21 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Aneuploidy (Aneuploid)
2. Hemorrhage
3. Spontaneous Abortion (Miscarriage)
4. Malaria
5. Infertility (Sterility)

Experts

1. Lin, Yi: 13 articles (12/2021 - 10/2005)
2. Clark, Robert L: 6 articles (01/2022 - 12/2004)
3. Yang, Jing: 6 articles (01/2019 - 11/2013)
4. Di, Jingfang: 5 articles (03/2011 - 10/2005)
5. Zeng, Shan: 5 articles (10/2009 - 10/2005)
6. Correa, Fernando: 4 articles (06/2017 - 08/2015)
7. Franchi, Ana María: 4 articles (06/2017 - 08/2015)
8. Wang, Wenjing: 4 articles (03/2011 - 06/2009)
9. Zhong, Yanmin: 4 articles (03/2011 - 06/2009)
10. Li, Da-Jin: 3 articles (10/2022 - 06/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Embryo Loss:
1. Prostaglandins DIBA
2. ProgesteroneFDA LinkGeneric
3. AntigensIBA
06/01/2005 - "Our findings suggest that paternal antigen-tolerant T cells transferred in recipient not only function as antigen-specific suppresser cells but also disable the recipient reactive T cells, which co-suppresses maternal rejection to the allogeneic fetus, thus resulting in the decrease of the embryo resorption rate of the abortion-prone mice to that of the normal pregnancy mice."
04/01/2020 - "In order to simulate immunostimulant-induced and immunostimulant-potentiated abortions, 0.83 mg/kg muramyl dipeptide β-heptylglycoside was intraperitoneally injected to CBA females mated with BALB/c or DBA/2 males, respectively, on gestation days 5 and 7. The increase in the rate of embryo resorption in the models of spontaneous, induced, and potentiated abortions occurred against the background of an increase in the level of spontaneous proliferation of splenocytes and a decrease in their reactivity to paternal antigens on gestation day 9."
04/01/2004 - "In the CBA/J x DBA/2 matings, anti-CD(80), CD(86) mAb administered at day 4 of gestation reduced significantly the embryo resorption rate, and induced a significantly lower proliferation response and IL-2 production by maternal splenic immuno-competent cells to paternal antigen compared with rat isotype IgG. In vivo blockade of costimulatory signal at day 4 of gestation can induce the immuno-tolerance of maternal peripheral immuno-competent cells to paternal antigen, thus leading the embryo resorption rate of the abortion-prone model to that of normal pregnancy model."
05/01/2002 - "The mouse models of spontaneous abortion CBA/J x DBA/2 were established, then we administrated the models by oral proper dosage antigens ovum albumin (OVA), trophoblast menbrane antigens trophoblast membrane antigen (TMA)1, TMA2 and observed the changes of embryo loss rate (ELR) as compared with the control groups: group without immunization, group of active immunization by injecting intraperitoneally spleenocytes and blank control by feeding normal saline (NS). "
01/01/1996 - "However, due to the short half-life of IgM antibodies, immunity to LPS was short-lived and the protective effect of LPS immunization against LPS induced abortion waned after 5 wk. Through the use of the CBA/J female x DBA/2 male model system to study spontaneous early embryo loss, previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freund's adjuvant (CFA) or LPS, all decreased the incidence of spontaneous resorption in subsequent pregnancies. "
4. AntibodiesIBA
5. Immunoglobulin M (IgM)IBA
6. Freund's AdjuvantIBA
7. PutrescineIBA
8. Acrolein (Aqualin)IBA
9. Glutathione (Reduced Glutathione)IBA
10. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric

Therapies and Procedures

1. Induced Abortion (Induced Abortions)
2. Curettage
3. Conservative Treatment
4. Therapeutics
5. Intrauterine Devices (Intrauterine Device)