Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)

GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.

Also Known As:

Networked: 88 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Casey, Patrick J: 5 articles (01/2014 - 05/2006)
2.	Wieland, Thomas: 3 articles (01/2013 - 09/2002)
3.	Siffert, Winfried: 3 articles (04/2009 - 01/2005)
4.	Kelly, Patrick: 3 articles (06/2007 - 05/2006)
5.	Daaka, Yehia: 3 articles (09/2006 - 09/2003)
6.	Koch, Walter J: 3 articles (12/2005 - 09/2003)
7.	Wettschureck, Nina: 2 articles (01/2016 - 10/2012)
8.	Semplicini, Andrea: 2 articles (09/2015 - 10/2004)
9.	Ceolotto, Giulio: 2 articles (09/2015 - 10/2004)
10.	Dulin, Nickolai O: 2 articles (06/2013 - 07/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12 signaling and cancer progression. " 09/08/2006 - "Many studies have suggested a role for the members of the G12 family of heterotrimeric G proteins (Galpha12 and Galpha13) in oncogenesis and tumor cell growth. " 07/01/2015 - "Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a Hydra." 06/01/2013 - "Heterotrimeric G proteins mediate myriads of cell functions including control of cancer cell proliferation and migration. " 04/01/2011 - "Herein, we illustrate the pathways of the four classes of α subunits and of the βγ subunits of these heterotrimeric G proteins especially with regard to their function in cancer. "
2.	Mood Disorders (Mood Disorder) 04/01/2006 - "A compilation of the most relevant research topics about the implication of heterotrimeric G proteins in the etiology of mood disorders (i.e., animal models of mood disorders, studies in peripheral tissue of depressive patients, and studies in postmortem human brain of suicide victims with mood disorders) will provide a broad perspective of this potential therapeutic target field. " 04/01/2006 - "Heterotrimeric g proteins: insights into the neurobiology of mood disorders." 01/15/2001 - "Heterotrimeric G proteins play a pivotal role in post-receptor information transduction and were previously implicated in the pathophysiology and treatment of mood disorders. " 02/01/1999 - "Information-transducing heterotrimeric G proteins have been implicated previously in the mechanism of action of mood stabilizers and in the pathophysiology of mood disorders. " 05/01/1998 - "Heterotrimeric G proteins were previously implicated in the biochemical mechanisms underlying the pathophysiology and treatment of mood disorders. "
3.	Whooping Cough (Pertussis) 04/01/1997 - "Because adenosine 3',5'-cyclic monophosphate (cAMP) and heterotrimeric G proteins may alter ion transporters, I tested whether cholera and pertussis toxins affected acidification of rat liver endosomes. " 12/01/1994 - "ADP-ribosylation of heterotrimeric G proteins by cholera and pertussis toxins decreased the Luk-PV-induced LTB4-generation. " 07/30/2002 - "GDP/GTP exchange assay data and studies with pertussis (PTX) toxin suggest that mastoparan may work directly to activate Cdc42 and not via PTX-sensitive heterotrimeric GTP-binding proteins. " 04/09/1999 - "BK-stimulated PI 3-kinase activity and NF-kappaB activation were sensitive to pertussis but not cholera toxin, suggesting that the B2 BK receptors transducing the response were coupled to Galphai or Galphao heterotrimeric G proteins. "
4.	Melanoma (Melanoma, Malignant) 07/01/2010 - "Our study is the first systematic analysis of the heterotrimeric G proteins in melanoma and indicates that multiple mutated heterotrimeric G proteins may be involved in melanoma progression." 12/02/2010 - "Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas. " 07/01/2010 - "Novel somatic mutations in heterotrimeric G proteins in melanoma." 07/01/2010 - "To further examine the role of heterotrimeric G proteins in malignant melanoma, we performed a comprehensive mutational analysis of the 35 genes in the heterotrimeric G protein gene family in a panel of 80 melanoma samples. " 04/16/1999 - "CXCR2 is a seven-transmembrane receptor that transduces intracellular signals in response to the chemokines interleukin-8, melanoma growth-stimulatory activity/growth-regulatory protein, and other ELR motif-containing CXC chemokines by coupling to heterotrimeric GTP-binding proteins. "
5.	Hyperplasia 12/01/2005 - "Intimal hyperplasia, a critical component in saphenous vein graft failure, is defined by vascular smooth muscle cell proliferation, which is mediated in part by betagamma subunits of heterotrimeric G proteins (G(betagamma)) and downstream effectors such as mitogen-activated protein kinases. " 01/01/2004 - "Several exemplary applications have now been generated in the vascular system, including the use of an adenovirus containing the carboxyl-terminus of the beta-adrenergic receptor kinase (beta ARKct), which binds to the beta gamma-subunits of activated heterotrimeric G proteins (G beta gamma), to study the in vivo role of G beta gamma in VSM intimal hyperplasia after vascular injury that leads to restenosis."

Related Drugs and Biologics

1.	mastoparan
2.	beta-Adrenergic Receptor Kinases
3.	Guanosine Triphosphate (GTP)
4.	Guanosine Diphosphate (GDP)
5.	aluminum fluoride
6.	GTP-Binding Proteins (G-Protein)
7.	GTP Phosphohydrolases (GTPases)
8.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
9.	Chemokines
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Homologous Transplantation (Allograft)