Neuroaspergillosis

Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Aspergillosis

Experts

1.	Kluge, Stefan: 1 article (03/2013)
2.	Sobottka, Ingo: 1 article (03/2013)
3.	Wichmann, Dominic: 1 article (03/2013)
4.	Loderstaedt, Ulrike: 1 article (03/2013)
5.	Deuse, Tobias: 1 article (03/2013)
6.	Soeffker, Gerold: 1 article (03/2013)
7.	Thiel, E: 1 article (01/2009)
8.	Sunami, Shigeko: 1 article (01/2009)
9.	Hiraga, Akiyuki: 1 article (01/2009)
10.	Kamitsukasa, Ikuo: 1 article (01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neuroaspergillosis:

1.	Antifungal AgentsIBA 01/01/2009 - "Data from animal models, which explored escalated doses or combinations of antifungal agents in experimental neuroaspergillosis, suggest that selected combination or dose-escalated therapies might further improve the still unsatisfactory prognosis in this particular type of Aspergillus infection."
2.	voriconazole (Vfend)FDA LinkGeneric 01/01/2009 - "Neuroaspergillosis in an immunocompetent patient successfully treated with voriconazole and a corticosteroid."
3.	galactomannanIBA 03/01/2013 - "We report on the successful detection and treatment monitoring by serial testing of galactomannan in cerebrospinal fluid in a patient with neuroaspergillosis after heart transplant."

Therapies and Procedures

1.	Transplants (Transplant) 03/01/2013 - "We report on the successful detection and treatment monitoring by serial testing of galactomannan in cerebrospinal fluid in a patient with neuroaspergillosis after heart transplant."
2.	Transplantation (Transplant Recipients) 03/01/2013 - "Invasive aspergillosis, especially neuroaspergillosis, predominantly affects immunocompromised patients such as transplant recipients. "