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Central Nervous System Lupus Vasculitis

Subscribe to New Research on Central Nervous System Lupus Vasculitis

Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.

Also Known As:

Lupus Vasculitis, Central Nervous System; Central Nervous System Lupus; Central Nervous System Systemic Lupus Erythematosis; Lupus Meningoencephalitis; Systemic Lupus Erythematosis, Central Nervous System; Lupus Meningoencephalitides; Meningoencephalitides, Lupus; Meningoencephalitis, Lupus; Neuropsychiatric Systemic Lupus Erythematosus

Networked: 122 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
2.	Lupus Nephritis
3.	Mood Disorders (Mood Disorder)
4.	Infection
5.	Encephalitis (Encephalitis, Rasmussen)

Experts

1.	Yoshio, Taku: 4 articles (11/2011 - 01/2005)
2.	Massardo, Loreto: 3 articles (06/2015 - 01/2006)
3.	Sibbitt, Wilmer L: 3 articles (10/2004 - 03/2002)
4.	Retamal, Claudio: 2 articles (06/2015 - 01/2015)
5.	Bravo-Zehnder, Marcela: 2 articles (06/2015 - 01/2015)
6.	González, Alfonso: 2 articles (06/2015 - 01/2015)
7.	Inestrosa, Nibaldo C: 2 articles (06/2015 - 01/2015)
8.	Segovia-Miranda, Fabián: 2 articles (06/2015 - 01/2015)
9.	Chen, Hua: 2 articles (01/2015 - 03/2011)
10.	Hu, Chaojun: 2 articles (01/2015 - 03/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Central Nervous System Lupus Vasculitis:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/01/1996 - "Pulse cyclophosphamide in the treatment of neuropsychiatric systemic lupus erythematosus." 01/01/1995 - "Role of intravenous cyclophosphamide in the treatment of severe neuropsychiatric systemic lupus erythematosus." 01/01/2004 - "Cyclophosphamide remains the 'gold standard' treatment for severe organ threatening systemic lupus erythematosus (SLE), especially renal and central nervous system lupus. " 09/01/2014 - "Cyclophosphamide efficacy in lupus nephritis (LN) and neuropsychiatric systemic lupus erythematosus (NPSLE) is probably mediated by a non-specific ablation of reactive lymphocytes. " 06/01/2010 - "Here we describe a case of neuropsychiatric systemic lupus erythematosus with catatonia and our treatment approach focusing on electroconvulsive therapy in conjunction with cyclophosphamide. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/01/1976 - "This suggests that massive doses of corticosteroids may be needed for effective treatment of central nervous system lupus." 02/01/2016 - "Corticosteroids in Lupus Nephritis and Central Nervous System Lupus." 03/01/1999 - "No significant association with calcification was noted for the following variables: age at disease onset, duration of the disease, sex, the maximum value of the serum calcium, organic phosphate, and uric acid, Raynaud's phenomenon, lupus nephritis, femoral avascular necrosis, central nervous system lupus, proteinuria, or the use of drugs such as corticosteroids, synthetic vitamin D, and nonsteroidal antiinflammatory drugs. "
3.	mycophenolate mofetil (Cellcept)FDA LinkGeneric 08/01/2005 - "We report a successfully treated case of neuropsychiatric systemic lupus erythematosus, presenting as psychosis, whose long-term remission was maintained on treatment with mycophenolate mofetil." 01/01/2015 - "We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). " 08/01/2005 - "Mycophenolate mofetil in neuropsychiatric systemic lupus erythematosus."
4.	AutoantibodiesIBA 04/01/2004 - "We undertook this study to examine the presence of autoantibodies to MAP-2 in neuropsychiatric systemic lupus erythematosus (NPSLE). " 08/01/2014 - "Cluster analysis of an array of autoantibodies in neuropsychiatric systemic lupus erythematosus." 10/08/2010 - "The role of measurement of serum autoantibodies in prediction of pediatric neuropsychiatric systemic lupus erythematosus." 04/01/2010 - "Autoantibodies against aquaporin-4 in patients with neuropsychiatric systemic lupus erythematosus and primary Sjögren's syndrome." 08/01/2008 - "Autoantibodies play an important role in central nervous system manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE). "
5.	AntibodiesIBA 03/01/2009 - "Antineuronal antibodies and electroneurophysiological studies in pediatric patients with neuropsychiatric systemic lupus erythematosus." 06/01/2014 - "We investigated possible associations between neurotoxic inflammatory mediators (IMs) and anti-U1RNP antibodies (Abs) in cerebrospinal fluid (CSF) of neuropsychiatric systemic lupus erythematosus (NPSLE). " 09/01/2011 - "NR2 antibodies in neuropsychiatric systemic lupus erythematosus." 05/01/2010 - "Anti-ribosomal P protein antibodies and neuropsychiatric systemic lupus erythematosus: cross-sectional vs. prospective studies." 04/27/2010 - "To investigate a target for antibodies in patients with neuropsychiatric systemic lupus erythematosus (NPSLE). "
6.	Biological Markers (Surrogate Marker)IBA 10/01/2015 - "Due to the lack of reliable biomarkers in diagnosing and monitoring neuropsychiatric systemic lupus erythematosus (NPSLE), the aim of this study was to examine the utility of measurements obtained through spectral domain optical coherence tomography (SD-OCT) as a biomarker for NP involvement in SLE. " 10/01/2014 - "Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers." 01/01/2014 - "Blood-based candidate biomarkers of the presence of neuropsychiatric systemic lupus erythematosus in children." 06/01/2011 - "Will anti-neuronal antibody biomarkers make neuropsychiatric systemic lupus erythematosus no longer a diagnosis of exclusion?" 05/01/2011 - "Delineation of mechanisms underlying neuropsychiatric systemic lupus erythematosus (NPSLE) and determination of biological markers could guide treatment choice. "
7.	MicroRNAs (MicroRNA)IBA 11/01/2014 - "Our findings suggest that the miRNAs reported in this study may represent novel therapeutic targets in central nervous system lupus and other similar neuroinflammatory settings."
8.	CytokinesIBA 01/01/2003 - "The objective was to study the occurrence of autoantibodies and cytokines in serum and cerebrospinal fluid (CSF) in neuropsychiatric systemic lupus erythematosus (NPSLE). "
9.	Interleukin-6 (Interleukin 6)IBA 02/01/2010 - "To clarify the clinical usefulness of cerebrospinal fluid (CSF) interleukin-6 (IL-6) measurement in patients with neuropsychiatric systemic lupus erythematosus (NPSLE), we studied CSF IL-6 levels in patients with NPSLE and analyzed the association between CSF IL-6 levels and other clinical findings of NPSLE. " 02/01/2010 - "Clinical analysis of cerebrospinal fluid interleukin-6 in neuropsychiatric systemic lupus erythematosus." 01/01/2015 - "According to transient ischemic attack that occurred repeatedly and an elevated level of interleukin-6 (IL-6) in spinal fluid, she was diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE). " 01/01/1994 - "CSF interleukin-6 (IL-6) in patients with CNS infection (374.24 +/- 92.61 pg/mL) and neuropsychiatric systemic lupus erythematosus (NP-SLE) (71.40 +/- 5.89 pg/mL) were significantly higher than in patients with CNS inflammation (33.92 +/- 29.36 pg/mL) or controls (non-inflammatory CNS diseases) (4.35 +/- 3.00 pg/mL). " 01/01/2013 - "However, normal interleukin-6 level and IgG index of cerebrospinal fluid and brain magnetic resonance imaging and single photon emission computed tomography findings suggested that her neurological symptoms were caused by metabolic disorder but not neuropsychiatric systemic lupus erythematosus. "
10.	Glutamate Receptors (Glutamate Receptor)IBA 02/01/2010 - "Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus." 02/08/2013 - "We investigated anti-GluRɛ2 antibodies in the serum and cerebrospinal fluid (CSF) of 15 PPATs, and we compared the results with those of 11 patients with neuropsychiatric systemic lupus erythematosus (NPSLE), an anti-glutamate receptor antibody-related disease. " 04/01/2008 - "Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus." 11/01/2011 - "Clinical analysis of anti-NR2 glutamate receptor antibodies and interleukin-6 with neuropsychiatric systemic lupus erythematosus." 02/01/2006 - "Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychiatric systemic lupus erythematosus."

Therapies and Procedures

1.	Plasmapheresis 04/01/2003 - "The role of plasmapheresis in the treatment of severe central nervous system neuropsychiatric systemic lupus erythematosus." 10/01/2001 - "We report our experience with use of plasmapheresis (PP) as an adjunct therapy in severe progressive neuropsychiatric systemic lupus erythematosus (NPSLE). "
2.	Stem Cell Transplantation 03/01/2000 - "This is the first description of successful autologous stem cell transplantation in a case of life threatening central nervous system lupus." 03/01/2000 - "Autologous stem cell transplantation in a case of treatment resistant central nervous system lupus."
3.	Lasers (Laser) 03/01/2011 - "Identify biomarkers of neuropsychiatric systemic lupus erythematosus by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with weak cation magnetic beads."
4.	Spinal Injections 11/01/2014 - "The objective is to explore the clinical curative effects of methylprednisolone combined with MTX and DXM intrathecal injection in treating neuropsychiatric systemic lupus erythematosus (NPSLE) and its effects on autoantibody level and anti-N-methyl-D-aspartate receptor subtype NR2a/2b antibody (anti-NR2 antibody) level. "
5.	Renal Dialysis (Hemodialysis) 06/10/2006 - "[Elderly male patient with central nervous system lupus undergoing hemodialysis]."