Neonatal Myasthenia Gravis (Transient Neonatal Myasthenia Gravis)

A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4)
Also Known As:
Transient Neonatal Myasthenia Gravis; Myasthenia Gravis, Neonatal; Myasthenia Gravis, Neonatal, Persistent; Myasthenia Gravis, Neonatal, Transient; Myasthenia Gravis, Persistent, Neonatal; Myasthenia Gravis, Transient, Neonatal; Neonatal Myasthenia Gravis, Persistent; Neonatal Myasthenia Gravis, Transient; Persistent Neonatal Myasthenia Gravis; Myasthenia Gravis, Antenatal; Antenatal Myasthenia Gravis
Networked: 32 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1. Myasthenia Gravis
2. Congenital Myasthenic Syndromes (Myasthenia Gravis, Congenital)
3. Muscle Weakness
4. Respiratory Insufficiency (Respiratory Failure)
5. Neuromyelitis Optica (Devic's Disease)


1. van der Zwaag, Angeli M: 1 article (01/2014)
2. Vrinten, Charlotte: 1 article (01/2014)
3. Weinreich, Stephanie S: 1 article (01/2014)
4. Scholten, Rob J P M: 1 article (01/2014)
5. Verschuuren, Jan J G M: 1 article (01/2014)
6. Faas, D: 1 article (08/2013)
7. Heckmann, M: 1 article (08/2013)
8. Welcker, S: 1 article (08/2013)
9. Axt-Fliedner, R: 1 article (08/2013)
10. Kanzaki, Akihiro: 1 article (03/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neonatal Myasthenia Gravis:
1. AntibodiesIBA
2. Acetylcholine (Acetylcholine Chloride)FDA Link
3. muskIBA
4. Neostigmine (Neostigmine Bromide)IBA
5. Immunoglobulins (Immunoglobulin)IBA
6. Immunoglobulin G (IgG)IBA
7. AntigensIBA
8. Blocking AntibodiesIBA
9. Proteins (Proteins, Gene)IBA
10. Phosphotransferases (Kinase)IBA

Therapies and Procedures

1. Nursing Care
2. Thymectomy
3. Immunomodulation
4. Prostheses and Implants (Prosthesis)
5. Plasmapheresis