Neurotrophin 3

A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.

Also Known As:

Networked: 84 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Riederer, P: 2 articles (10/2017 - 10/2001)
2.	Fenstermacher, David A: 2 articles (02/2015 - 03/2014)
3.	Forsyth, Peter A: 2 articles (02/2015 - 03/2014)
4.	Fournier, Michelle: 2 articles (02/2015 - 03/2014)
5.	Kenchappa, Rajappa S: 2 articles (02/2015 - 03/2014)
6.	Krishna, Niveditha: 2 articles (02/2015 - 03/2014)
7.	Lawn, Samuel: 2 articles (02/2015 - 03/2014)
8.	Qu, Xiaotao: 2 articles (02/2015 - 03/2014)
9.	Choi, Byung Tae: 1 article (07/2022)
10.	Jung, Da Hee: 1 article (07/2022)

Related Diseases

1.	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/01/2021 - "Based on the multiple biological effects of this versatile molecule, we predict neurotrophin 3 has the potential to be beneficial in other aminoacyl-tRNA synthetase-linked Charcot-Marie-Tooth disease subtypes." 01/01/2021 - "This study shows that neurotrophin 3 gene transfer therapy has disease modifying effect in a mouse model for Charcot-Marie-Tooth disease type-2D, leading to meaningful improvements in peripheral nerve myelination and neuromuscular junction integrity as well as in a unique myopathic process, associated with mitochondria dysfunction, all in combination contributing to functional outcome. "
2.	Stroke (Strokes) 09/02/2014 - "Stroke mice that received repeated neuronal stimulations exhibited significant improvement in cerebral blood flow and the neurovascular coupling response, as well as increased expression of activity-dependent neurotrophins in the contralesional cortex, including brain-derived neurotrophic factor, nerve growth factor, and neurotrophin 3. Western analysis also indicated that stimulated mice exhibited a significant increase in the expression of a plasticity marker growth-associated protein 43. "
3.	Medulloblastoma 07/01/2005 - "Our investigation of the mechanism of neurotrophin-3/TrkC-induced apoptosis has identified a novel role for both MEK5/ERK5 and MEF2 in cell death, suggesting that these molecules can be exploited to induce apoptosis in both TrkC-expressing and non-expressing medulloblastoma cells." 07/01/2005 - "In the present study, we investigate the contribution of ERK5 and its target myocyte enhancer factor 2 (MEF2) to neurotrophin-3/TrkC-induced medulloblastoma cell death. " 02/01/2009 - "Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY." 01/01/2020 - "Neurotrophin 3 (NTF3) is a member of the nerve growth factor (NGF) family involved in cancer progression, including medulloblastoma and breast cancer. " 01/01/2022 - "Neurotrophin 3 (NTF3) is a member of the nerve growth factor (NGF) family that is involved in the progression of various cancers, including medulloblastoma, primitive neuroectodermal brain tumors, and breast cancer. "
4.	Ganglion Cysts (Ganglion) 08/15/2008 - "Interactive roles of fibroblast growth factor 2 and neurotrophin 3 in the sequence of migration, process outgrowth, and axonal differentiation of mouse cochlear ganglion cells." 01/01/2017 - "The aim of the present study was to characterize the effects of the neurotrophins nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) on the sprouting rate of sympathetic and parasympathetic neurites from the female mouse ganglion. " 08/12/2009 - "RT-PCR data, in accord with the microarray analysis, indicated that untreated SHRs had lower mRNA expression levels of cAMP responsive element binding protein 1 (Creb1) in the pelvic ganglion and vascular endothelial growth factor A (Vegfa) and kinase insert domain protein receptor (Kdr) in the penis, and higher mRNA expression levels of brain derived neurotrophic factor and neurotrophin 3 (Ntf3) in the bladder and Ntf3, Rho-kinases (Rock1 and Rock2) and caveolin 1 (Cav1) in the penis than untreated WKY rats. "
5.	Schizophrenia (Dementia Praecox) 12/01/2004 - "To reach a conclusive understanding of the association, we used a meta-analytic method to study the association of schizophrenia with the polymorphisms in two candidate genes, ciliary neurotrophic factor (CNTF) and neurotrophin 3 (NT3). " 01/01/2019 - "Neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin 3 (NT3) and Nerve Growth Factor (NGF), play a role in neuroplasticity and neurogenesis contributing to the pathogenesis of schizophrenia. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	Nerve Growth Factors (Neurotrophins)
3.	Nerve Growth Factor (NGF)
4.	GAP-43 Protein (GAP 43 Protein)
5.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
6.	Messenger RNA (mRNA)
7.	Phosphotransferases (Kinase)
8.	neurotrophin 4
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Tropomyosin

Related Therapies and Procedures

1.	Therapeutics
2.	Low-Level Light Therapy (LLLT)
3.	Intraventricular Infusions
4.	Drug Therapy (Chemotherapy)
5.	Denervation