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Mitogen-Activated Protein Kinase Kinases (MEKs)

A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Also Known As:
MEKs; Map Kinase Kinase; Kinase, Map Kinase; MAP-ERK Kinase; MAPKK; Kinase Kinase, Map; Kinase Kinases, MAP; Kinase, MAP-ERK; Kinase, MAPK; Kinase, MAPK-ERK; Kinases, MAP Kinase; Kinases, MAPK; Kinases, MAPK-ERK; MAP ERK Kinase; MAPK ERK Kinase; MAPK ERK Kinases; Mitogen Activated Protein Kinase Kinase; Mitogen Activated Protein Kinase Kinases; MAP Kinase Kinases; MAPK Kinase; MAPK Kinases; MAPK-ERK Kinase; MAPK-ERK Kinases; MAPKKs; MEK; Mitogen-Activated Protein Kinase Kinase
Networked: 6698 relevant articles (533 outcomes, 810 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Long, Georgina V: 54 articles (02/2022 - 11/2012)
2. Flaherty, Keith T: 52 articles (01/2021 - 05/2006)
3. Dummer, Reinhard: 47 articles (01/2022 - 12/2009)
4. Schadendorf, Dirk: 47 articles (01/2022 - 02/2007)
5. Ascierto, Paolo A: 42 articles (01/2022 - 07/2012)
6. Ribas, Antoni: 42 articles (01/2021 - 01/2011)
7. Aplin, Andrew E: 37 articles (01/2022 - 05/2005)
8. Robert, Caroline: 35 articles (01/2021 - 01/2012)
9. Rosen, Neal: 33 articles (11/2021 - 12/2007)
10. Garbe, Claus: 32 articles (01/2022 - 09/2005)

Related Diseases

1. Melanoma (Melanoma, Malignant)
2. Neoplasms (Cancer)
3. Colorectal Neoplasms (Colorectal Cancer)
4. Lung Neoplasms (Lung Cancer)
5. Plexiform Neurofibroma

Related Drugs and Biologics

1. trametinib
2. Mitogen-Activated Protein Kinase Kinases (MEKs)
3. Immune Checkpoint Inhibitors
4. dabrafenib
5. Vemurafenib
6. cobimetinib
7. Proteins (Proteins, Gene)
8. Phosphotransferases (Kinase)
9. Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
10. AZD 6244

Related Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Drug Therapy (Chemotherapy)
4. Molecular Targeted Therapy
5. Radiotherapy