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Dexmedetomidine

Subscribe to New Research on Dexmedetomidine

A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.

Also Known As:

Dexmedetomidine Hydrochloride; Hospira Brand of Dexmedetomidine Hydrochloride; MPV-1440; Precedex; Hydrochloride, Dexmedetomidine; MPV 1440; MPV1440; 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, (R)-

Networked: 1196 relevant articles (153 outcomes, 244 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Imidazoles: 107
      - Dexmedetomidine: 1196

Experts

1.	Tobias, Joseph D: 31 articles (06/2015 - 04/2003)
2.	Kunisawa, Takayuki: 11 articles (01/2014 - 09/2005)
3.	Mason, Keira P: 10 articles (06/2014 - 05/2008)
4.	Iwasaki, Hiroshi: 10 articles (01/2014 - 09/2005)
5.	Ely, E Wesley: 9 articles (08/2015 - 06/2005)
6.	Komasawa, Nobuyasu: 9 articles (05/2015 - 12/2013)
7.	Hanci, Volkan: 9 articles (12/2014 - 11/2009)
8.	Chrysostomou, Constantinos: 8 articles (02/2014 - 03/2006)
9.	Finkel, Julia C: 7 articles (11/2015 - 09/2005)
10.	Quezado, Zenaide M N: 7 articles (11/2015 - 09/2005)

Related Diseases

1.	Pain (Aches) 09/01/2008 - "Dexmedetomidine administration resulted in a significant reduction in pain scores for 6 h after operation in the intra-articular group but only for 1 h in the i.v. group. " 01/01/2015 - "Dexmedetomidine was proved effective for preventing EA and for reducing severe pain and the requirement of rescue drugs. " 07/01/2014 - "Using continuous local anesthetic infusions instead of dexmedetomidine could eliminate the need for ICU admission, require shorter hospital stays, and reduce costs while still providing safe and effective pain control." 05/01/2014 - "The aim of this study was to evaluate the efficacy of dexmedetomidine along with LA field infiltration in controlling pain and discomfort associated with CVC insertion. " 09/01/2004 - "This study documents that systemic dexmedetomidine lacks analgesic efficacy for heat and electrical pain at doses causing mild to severe sedation. "
2.	Delirium 02/01/2015 - "In the dexmedetomidine group, delirium rating scale was significantly smaller than that of the control group (P<0.05) while Ramsay sedation score was significantly greater than that of the control group (P<0.05). " 04/01/2014 - "Dexmedetomidine infusion during CABG surgery was more likely to achieve improved in-hospital, 30-day, and 1-year survival rates, and a significantly lower incidence of delirium." 04/01/2011 - "Dexmedetomidine may help to eliminate the emergence of agitation and can be a good treatment choice for the delirium state after cardiac surgery." 01/01/2015 - "Dexmedetomidine has also been shown to be effective in limiting risk factors associated with ICU delirium such as length and depth of sedation. " 10/01/2007 - "Dexmedetomidine is effective for controlling delirium and provides sufficient sedation without respiratory adverse effects in patients in the intensive care unit. "
3.	Postoperative Pain 09/01/2015 - "We assessed the efficacy of intravenous dexmedetomidine as an analgesic adjunct to local anesthetic infiltration for control of postoperative pain in arthroscopic knee surgery. " 04/01/2013 - "We studied efficacy of caudal dexmedetomidine (DEX) on attenuation of perioperative stress response and postoperative pain in pediatric patients undergoing cardiac surgery. " 04/01/2013 - "The efficacy of caudal dexmedetomidine on stress response and postoperative pain in pediatric cardiac surgery." 02/01/2013 - "Efficacy and safety of intraoperative dexmedetomidine for acute postoperative pain in children: a meta-analysis of randomized controlled trials." 10/05/2015 - "These findings have led to the hypothesis that the local administration of dexmedetomidine is useful for relieving acute inflammatory nociception, such as postoperative pain. "
4.	Ischemia 06/01/2015 - "The aim of this study was to evaluate the protective effects of dexmedetomidine on cell proliferation, antioxidant system, cell death, and structural integrity in intestinal injury induced by ischemia-reperfusion in rats. " 01/01/2013 - "To investigate the protective effects of dexmedetomidine against hepatic ischemia/reperfusion (IR) injury and hepatic IR induced remote organ injury. " 01/01/2011 - "We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) provides protection against ischemia-reperfusion induced kidney injury in vitro and in vivo. " 11/01/1993 - "Dexmedetomidine (Group 3) improved outcome from ischemia in comparison to both Groups 1 and 2 (P < 0.05). " 12/01/2014 - "This study aimed to investigate whether preconditioning by using dexmedetomidine (DEX) decreased the occurrence of ischemia in inner cells of the ear. "
5.	Reperfusion Injury 01/01/2014 - "The protective effects of dexmedetomidine on hepatic ischemia reperfusion injury." 01/01/2013 - "The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats." 06/01/2014 - "Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury." 01/01/2012 - "The aim of this study was to evaluate the effect of dexmedetomidine on lipid peroxidation and erythrocyte deformability during ischemia-reperfusion injury in rats. " 12/01/2010 - "In this study, we administered dexmedetomidine after ischaemia to investigate its ability to protect the cardiac muscle from ischaemia-reperfusion injury in isolated rat hearts. "

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Related Therapies and Procedures

1.	Anesthesia
2.	Artificial Respiration (Mechanical Ventilation)
3.	Analgesia
4.	Premedication
5.	General Anesthesia