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Complex Regional Pain Syndromes

Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)
Also Known As:
CRPS (Complex Regional Pain Syndromes); Acute Regional Pain Syndrome; Chronic Regional Pain Syndrome; Complex Regional Pain Syndrome; Pain Syndromes, Regional Complex
Networked: 1133 relevant articles (94 outcomes, 157 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pain (Aches)
2. Neuralgia (Stump Neuralgia)
3. Chronic Pain
4. Failed Back Surgery Syndrome
5. Diabetic Neuropathies (Diabetic Neuropathy)

Experts

1. Birklein, Frank: 30 articles (12/2022 - 09/2003)
2. Goebel, Andreas: 28 articles (03/2022 - 03/2005)
3. Schwartzman, Robert J: 21 articles (08/2021 - 06/2003)
4. Kingery, Wade S: 21 articles (01/2021 - 03/2009)
5. Clark, J David: 18 articles (03/2022 - 03/2009)
6. Huygen, Frank J P M: 15 articles (11/2021 - 12/2005)
7. Alexander, Guillermo M: 15 articles (08/2021 - 03/2009)
8. Guo, Tian-Zhi: 15 articles (01/2021 - 03/2009)
9. Li, Wen-Wu: 12 articles (01/2021 - 12/2009)
10. Ajit, Seena K: 11 articles (09/2021 - 11/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Complex Regional Pain Syndromes:
1. KetamineFDA LinkGeneric
2. Lidocaine (Xylocaine)FDA LinkGeneric
3. Ascorbic Acid (Vitamin C)FDA LinkGeneric
4. Clonidine (ST 155)FDA LinkGeneric
5. Biomarkers (Surrogate Marker)IBA
6. Adrenal Cortex Hormones (Corticosteroids)IBA
7. Gabapentin (Neurontin)FDA LinkGeneric
8. GuanethidineFDA Link
9. SympatholyticsIBA
10. BaclofenFDA LinkGeneric

Therapies and Procedures

1. Spinal Cord Stimulation
2. Therapeutics
3. Physical Therapy Modalities (Physical Therapy Technique)
4. Mirror Movement Therapy
5. Analgesia