Ketorolac Tromethamine (Acular)

A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is a non-steroidal anti-inflammatory agent used for analgesia for postoperative pain and inhibits cyclooxygenase activity.

Also Known As:

Networked: 262 relevant articles (50 outcomes, 57 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Vroman, David T: 3 articles (12/2007 - 01/2002)
2.	Sandoval, Helga P: 3 articles (12/2007 - 01/2002)
3.	Solomon, Kerry D: 3 articles (12/2007 - 01/2002)
4.	Donnenfeld, Eric D: 3 articles (07/2007 - 01/2006)
5.	Solomon, K D: 3 articles (11/2002 - 02/2001)
6.	Carr, Daniel B: 2 articles (08/2013 - 11/2012)
7.	Hamilton, Douglas A: 2 articles (08/2013 - 11/2012)
8.	Cardoso, Gilberto Perez: 2 articles (08/2011 - 07/2010)
9.	Wittpenn, John R: 2 articles (10/2008 - 09/2006)
10.	Sinha, Vivek Ranjan: 2 articles (08/2008 - 05/2005)

Related Diseases

1.	Pain (Aches) 01/01/2011 - "The efficacy of a nonsteroidal anti-inflammatory agent, ketorolac tromethamine, was evaluated in pain control after periodontal surgery. " 04/01/2011 - "It was planned to give supplemental buccal infiltration of 1 mL/30 mg of ketorolac tromethamine in 26 patients, but the first 2 patients experienced severe injection pain after ketorlac infiltration and were excluded from the study. " 08/01/2002 - "In the second study, subjects received either ketorolac tromethamine 30 mg by the intravenous route or placebo at pain onset. " 02/01/2012 - "SPRIX (ketorolac tromethamine) nasal spray: a novel nonopioid alternative for managing moderate to moderately severe dental pain." 01/01/2011 - "Thus, there may be an advantage in pretreatment administration of ketorolac tromethamine, 10 mg, compared with placebo on operative pain during periodontal surgery. "
2.	Cataract (Cataracts) 08/01/2014 - "Prophylactic use of ketorolac tromethamine in cataract surgery: a randomized trial." 08/01/2014 - "There was no difference between ketorolac tromethamine and a placebo with regard to BCVA results or prevention of CME after uncomplicated cataract surgery." 08/01/2000 - "Acular as a single agent for use as an antimiotic and anti-inflammatory in cataract surgery." 08/01/2006 - "Treatment with 0.4% ketorolac tromethamine ophthalmic solution is as effective as 0.5% ketorolac tromethamine ophthalmic solution in reducing inflammation after routine cataract surgery. " 08/01/2014 - "To determine the efficacy of topical ketorolac tromethamine in preventing cystoid macular edema (CME) after uncomplicated cataract surgery. "
3.	Inflammation 08/01/2004 - "Efficacy of low concentrations of ketorolac tromethamine in animal models of ocular inflammation." 08/01/2004 - "To determine if topical ophthalmic application of ketorolac tromethamine concentrations below 0.5% can block the biochemical and physiological processes associated with chemically induced ocular inflammation in rabbits. " 01/01/1985 - "When applied topically in rat and rabbit models of ocular inflammation, less than or equal to 0.5% solutions of ketorolac tromethamine inhibited the inflammatory response." 01/01/2000 - "Topical Ketorolac-Tromethamine has demonstrated a significant reduction of endotoxin-induced-uveitis inflammation." 08/01/2006 - "Treatment with 0.4% ketorolac tromethamine ophthalmic solution is as effective as 0.5% ketorolac tromethamine ophthalmic solution in reducing inflammation after routine cataract surgery. "
4.	Postoperative Pain 01/01/1993 - "The purpose of this study was to determine the efficacy of a ketorolac tromethamine used for the management of the postoperative pain produced as a result of outpatient ACL reconstruction. " 02/01/1996 - "A double-blind, randomized, single-dose clinical trial to evaluate the analgesic efficacy of preoperative ketorolac tromethamine administration on periodontal postoperative pain was designed. " 01/01/1990 - "The efficacy and safety of the analgesic drug ketorolac tromethamine in the treatment of moderate to very severe postoperative pain was assessed in five dose-ranging studies with single-dose, double-blind, randomized, parallel-group designs. " 05/01/2015 - "Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that provides postoperative pain control and reduces narcotic requirements. " 01/01/2009 - "Fifteen children in the experimental group received oral infiltration of local anesthetic in addition to intravenous ketorolac tromethamine, while 12 children in the control group received intravenous ketorolac tromethamine alone for postoperative pain management. "
5.	Macular Edema 04/15/1987 - "The effect of ketorolac tromethamine 0.5% ophthalmic solution (a new nonsteroidal anti-inflammatory agent) treatment was compared to placebo treatment in patients with chronic, angiographically proven aphakic or pseudophakic cystoid macular edema (visual acuity less than or equal to 20/40 for six months) during a three- to four-month double-masked, randomized study. " 08/01/2010 - "Use of intraocular ketorolac tromethamine for the treatment of chronic cystoid macular edema." 11/15/1991 - "Ketorolac tromethamine 0.5% ophthalmic solution treatment was compared to placebo treatment in 120 patients with chronic aphakic or pseudophakic cystoid macular edema (six-month or more duration of distance visual acuity of 20/40 or less and angiographic evidence of cystoid changes) during a four- to five-month double-masked, multicenter study in which patients were randomly assigned. " 04/15/1987 - "Effectiveness of ketorolac tromethamine 0.5% ophthalmic solution for chronic aphakic and pseudophakic cystoid macular edema." 11/15/1991 - "Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine."

Related Drugs and Biologics

1.	Ketorolac
2.	Ketorolac Tromethamine (Acular)
3.	Acetaminophen (Paracetamol)
4.	Diclofenac (SR 38)
5.	Ophthalmic Solutions (Eye Drops)
6.	Meperidine (Pethidine)
7.	prednisolone acetate
8.	Atropine (Hyoscyamine)
9.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
10.	nepafenac (Nevanac)

Related Therapies and Procedures

1.	Phacoemulsification
2.	Thoracotomy
3.	Intraocular Lenses (Intraocular Lens)
4.	Cataract Extraction
5.	Light Coagulation